This paper implements a Hardware Accelerator (HA) for Wireless Body Sensor Networks (WBSNs) using 28 nm technology on Zynq system-on-a-chip (SOC) using Vivado and VITIS high-level synthesis tool. The Vitis integrated development environment (IDE) is a software-only development environment that Integrates with other Xilinx tools. The Zynq® SoC combines a state-of-the-art processor system (PS) and programmable logic (PL) into a single cohesive device. WBSNs contain different processing techniques like predictor, compressor, encryption encoder, and Error Control Coding (ECC) before transmission. These techniques are implemented and validated using the Xilinx® Software Development Kit (SDK) tool along with the PYNQ Z2 board having Zynq SOC respectively. Similarly, the processing techniques are implemented on PS block as HA. The results of the work show the data collection and processing through the dual-core ARM Cortex A9 processor of the board. The purpose of the work is to calculate the time required to process the bio-signals through the controller solely and using HA. The proposed work, mainly WBSN using HA shows an improvement of 81% in the speed compared with existing methods. Further, results of the synthesis and implementation strategy show improvement in power and area of HA with WBSN.