Soil and groundwater contamination has become a key issue in urban redevelopment. It is particularly difficult to use heavy equipment for the remediation of restricted sites or areas contaminated by factories that are still in operation. In this case, horizontal wells are considered a potentially useful technology as they can potentially remediate contamination areas located below buildings and other surface/subsurface obstacles. This research first introduces the principles and advantages and disadvantages of direct push injection, improved slant well, high-pressure rotary jet technology, horizontal reactive media treatment wells, and horizontal directional drilling well. The key aspects for promising in-situ remediation techniques were summarized as remediation well design, remediation agent injection technology and drill pipe and well wall sealing technology. Based on the requirements for key technologies, a novel multi-branch horizontal well in-situ remediation process was proposed, which integrates vertical/horizontal directional drilling, rotary injection, and expansion sealing techniques, and relevant supporting drilling and injecting equipment were developed. A bench test and field test were conducted to test drilling tool performance, drilling accuracy, and injection radius of influence. The results showed that the developed supporting drilling tool met the process requirements and could complete multi-branch horizontal well remediation engineering construction. The deviation between the measured depth and the design depth of the multi-branch horizontal well constructed using this technology was less than 9%, and the deviation between the depth displayed by the guidance instrument and the measured depth was less than 1%. The injection radius of influence in the test field measured from the monitoring wells was greater than or equal to 5 m. The results of this research can provide an effective method for the remediation of contaminated sites.