Universal quantum computation requires the implementation of arbitrary control operations on the quantum register. In most cases, this is achieved by external control fields acting selectively on each qubit to drive single-qubit operations. In combination with a drift Hamiltonian containing interactions between the qubits, this allows the implementation of arbitrary gate operations. Here, we demonstrate an alternative scheme that does not require local control for all qubits: we implement one- and two-qubit gate operations on a set of target qubits indirectly, through a combination of gates on directly controlled actuator qubits with a drift Hamiltonian that couples actuator and target qubits. Experiments are performed on nuclear spins, using radio-frequency pulses as gate operations and magnetic-dipole couplings for the drift Hamiltonian.