To study the scale effect on propeller bearing forces in oblique flow, the propeller bearing forces of a fully appended four-screw ship that refers to a vessel propelled by four propellers are calculated and investigated. The findings reveal that scale effects in wake fields lead to an increase in the axial velocity of the propeller disk in the full-scale ship compared to the model, influenced by boundary layer flow. Moreover, asymmetric differences in the impact of oblique flow on the leeward and windward sides result in varied effects of positive and negative drift angles on the wakefield. The disparity in wake fields between inside and outside disks exacerbates unbalanced load distribution, with time-averaged loads showing an increase with drift angle for both propellers at full scale. Additionally, pronounced scale effects lead to variations in blade loads between model and full scale, with drift angles shifting the locations of single-blade load extremums. Unsteady bearing force components exhibit periodic fluctuations, with larger amplitudes at the blade passage frequency for the model scale propeller compared to the full scale, particularly evident under negative drift angles. The aforementioned findings can provide theoretical guidance for load balancing and vibration reduction of the four-screw ships.