This study presents a more rigorously defined and explicitly mapped ‘Drakensberg’ centre of plant endemism that aligns floristic and ecological boundaries. It also revisits the plant endemics recorded previously for the former Drakensberg Alpine Centre and makes necessary changes due to molecular-based taxonomic revisions, increased collecting intensity in the Great Escarpment and montane outliers, and improved accessibility to online herbarium records. The mooted conceptual phytogeographic framework termed the Drakensberg Mountain Centre (DMC) is further developed to include two sub-centres of plant endemism, namely the Maloti Alpine and Drakensberg Montane Sub-centres, aligned to discrete geomorphic provinces and eco-thermal vegetation belts. The DMC covers an area of almost 36,500 km2, with some two-thirds montane and one-third alpine. This study recognises 227 endemic angiosperms, or c. 9% angiosperm endemism in the DMC. This is a 4% reduction in the endemic element from the earlier account of Carbutt and Edwards (2006). Only c. 33% of the endemics are shared between the alpine and montane sub-centres, suggesting a strong partitioning of endemics in their respective alpine and montane habitats. Previously recognised montane outliers such as Mahwaqa Mtn, Mt. Currie and Ngeli Mtn are excluded from the revised and consolidated boundary.