This paper presents an exergy transfer analysis for turbulent drag reducing surfactant solution flow with and without heat transfer enhancement devices which employ static or dynamic mixers. Heat transfer and pressure drop measurements were performed at an inlet temperature of 297.7–298.2 K in pipe flow with a concentric tube heat exchanger. The environmental temperature in the analysis was set to be 288.2 K in assumption of a cooling system. The experimental range of the Reynolds number was 1.0×104 to 4.2×104. Adding surfactant to a water flow decreases the exergy transfer Nusselt number, Nue, owing to the heat transfer reduction and increases the exergy transfer efficiency, ηeff, by a maximum of 9.3% at high Reynolds numbers at moderate fluid transport distance owing to the drag reduction. Also the secondary flow caused by the enhancement devices increases Nue. The proposed flow performance curve which provides ηeff for an arbitrary Nue shows that ηeff in viscoelastic fluid flow compared to Newtonian fluid flow is small independently of the fluid transport distance, and that the installation of heat transfer enhancement devices has a positive effect on energy-saving in certain ranges of Reynolds numbers and fluid transport distances.