Beef cattle feedlot particulate matter (PM) is a complex mixture of dust, animal waste, agrochemicals, and bioaerosols. However, no empirical data exist quantifying downwind residential exposure to PM or PM-bound agrochemicals. In the current study, authors investigated transport of PM and co-occurring insecticides and anthelmintics downwind of three feedlots in the Southern Great Plains (SGP) of North America from May–August 2022. PM collected on total suspended particulate (TSP) filters was analyzed via UHPLC-MS/MS for six pyrethroids and five macrocyclic lactones (MLs). Downwind TSP concentrations rapidly declined from 0.01 to ≤1.6 km (Monte Carlo mean ± SEM; 5049 ± 96.1 μg/m3) and stabilized >1.6–12.4 km (1791 ± 9.9; μg/m3). Distance decay >1.6 km indicated downwind PM exceeded levels of safe human exposure during diurnal peak periods. Pyrethroids and MLs were detected >LOQ in 96.2 and 98.1 % of downwind samples. Screening-level cumulative residential exposure indicates elevated pyrethroid risk (LOC = 1; RI = 0.173) to rural children (1–2 yrs) living near cropland operations in the SGP, with disproportionate co-exposure to feedlot PM and legacy pollution in low-income, Hispanic and Latino communities. Frequent occurrence and sustained transport of pyrethroids downwind of feedlots facilitate residue accumulation in outdoor residential areas that must also be quantified to assess the magnitude of daily average and lifetime-adjusted oral and dermal exposure in surrounding communities. Results significantly expand the known distribution of feedlot-derived PM and agrochemicals and highlight human exposure pathways unrecognized in residential human health assessments supporting pesticide registration and feedlot risk evaluation.