A Numerical investigation on the influence of heater and condenser orientation and its location on steady state performance of a Two Phase Natural Circulation Loop (TPNCL) is presented. In the present study, four possible orientations are considered in TPNCL namely, Vertical Heater and Vertical Condenser (VHVC), Vertical Heater and Horizontal Condenser (VHHC), Horizontal Heater and Horizontal Condenser (HHHC) and Horizontal Heater and Vertical Condenser (HHVC). An in house MATLAB code is developed to solve the systems of equations. Homogeneous equilibrium model (HEM) is used in two phase regions. It is observed that steady state mass flow rate of the loop is significantly influenced by the developed pressure gradient in the riser and downcomer sections, as well as available vapour quality in the riser section. Moreover, it is also noticed that condenser position and orientation significantly effects the thermo-hydraulic characteristic of loop compared with heater orientation.