A diode-pumped, actively mode-locked high-power thulium (Tm3+)-doped double-clad silica fiber laser is demonstrated, providing an average output power in mode-locked (continuous wave) operation of 53 W (72 W) with a slope efficiency of 34% (38%). Mode-locking in the 6th-harmonic order was obtained by an acousto-optic modulator driven at 66 MHz without dispersion compensation. The shortest measured output pulse width was 200 ps. Owing to a diffraction grating as cavity end mirror, the central wavelength could be tuned from 1.95 to 2.13 μm. The measured beam quality in mode-locked and continuous wave operation has been close to the diffraction limit.