Doses Of Potassium Chloride Research Articles

The effect of potassium supplementation and concomitant medications on potassium homeostasis for hospitalized patients.

Hospitalized patients receive potassium (K+) supplementation for hypokalemia, with clinicians often estimating a rise in serum K+ levels of 0.1 mEq/L per 10 mEq delivered. However, there is limited evidence to support this expectation. Patients also concomitantly take medications that may alter K+ levels, and it is not known to what degree these may impact interventions to correct K+ levels via supplementation. The objective of this study was to identify the impact of oral and/or intravenous K+ supplementation on serum K+ levels, including the influence of selected concomitant medications, in adult hospitalized patients. A single-center, retrospective descriptive study of adult hospitalized patients receiving K+ supplementation at a tertiary hospital between 2021 and 2022 was conducted. Patients were included if they received at least one dose of potassium chloride while admitted to the general medicine ward. The primary outcome was the daily median change in serum K+, normalized per 10 mEq of supplementation administered. The secondary outcome was the impact of selected concomitant medication use on supplement-induced changes in serum K+. A total of 800 patients and 1,291 daily episodes of K+ supplementation were evaluated. The sample was approximately 53% women, was 78% white, and had a median age of 68 years. The overall daily median change in serum K+ level was 0.05 mEq/L per 10 mEq of supplementation delivered. Patients received a median of 40 mEq of supplementation per day, primarily via the oral route (80.6%). Among the concomitant medications assessed, loop diuretics significantly dampened the impact of K+ supplementation. Supplementation of K+ in non-critically ill hospitalized patients is variable and dependent on concomitant medication use.

Characteristics of watermelon fruits under different fertilization management in semi-arid climate conditions / Características de frutos de melancia sob diferentes manejos de adubação em condições de clima semiárido

This study was conducted to evaluate the production and quality of watermelon fruits, submitted to different doses of potassium chloride (KCl) in fertigation and conventional fertilization systems. Talisman F1 was used as a plant material. It was carried out in a randomized complete block design, in a 2x4 split-plot scheme, with four replications. In the plots, the conventional and fertigation systems were tested and in the subplots the doses of KCl, equals: 0, 60, 120 and 180 kg ha-1 of K2O were tested. Seventy days after planting, were determined: total number of fruits; average weight of total fruits; total fruit production; average number of commercial fruits; average weight of commercial fruits and commercial fruit production, as well the hydrogenic potential (pH), total soluble solids (TSS), total titratable acidity (TTA) and TSS/TTA ratio. There was interaction between fertilization systems and K2O rates for commercial productivity with a linear increase under fertigation, which, in turn, increased TTA. 180 kg ha-1 of K2O in a conventional fertilization system, confirm possible metabolic changes not conducive to the cultivation and production of 'Talisman F1' watermelon. The fertilization system by fertigation represents an alternative for the cultivation of watermelon, considering the productivity and quality of fruits.

The Pitfalls of the Ethical Continuum and its Application to Medical Aid in Dying

The Pitfalls of the Ethical Continuum and its Application to Medical Aid in Dying

Doses of limestone, phosphorus and potassium on the initial development of Anacardium humile seedlings

The objective of this work was to evaluate the effect of different doses of limestone, phosphorus, and potassium on the initial development of Anacardium humile (Cajuzinho-do-cerrado) seedlings. The experiment was conducted in a greenhouse. A randomized block design was adopted in a 3x4x4 factorial scheme (liming x phosphorus x potassium doses). The treatments consisted of three liming doses (0; 40; and 70% of base saturation), four doses of potassium chloride with 60% of K2O (0; 60; 120; and 180 kg ha-1), and four doses of triple superphosphate with 46% of P2O5 (0; 80; 160; and 240 kg ha-1), with six replications. The following characteristics were evaluated: stem diameter (SD), plant height (PH), root length (RL), shoot dry matter (SDM), and root dry matter (RDM). The data were submitted to analysis of variance and the averages were compared by Tukey’s test (p < 0.05). It was concluded that there was no influence of phosphorus doses on the initial development of A. humile seedlings and that there was a response to the association between liming and potassium chloride in vegetative growth.

Production and quality of mango fruits cv. Tommy atkins fertigated with potassium in semi-arid region

Abstract Correct management of potassium (K) fertilization is of fundamental importance for mango orchards, and K is one of the most exported and yield-limiting nutrients. Thus, an experiment was carried out to evaluate the production and physical-chemical characteristics of Tommy Atkins mango fruits under fertigation with different doses of potassium chloride and potassium sulfate in the semi-arid region. The experimental design was randomized blocks in split plots, using five K doses (50, 75, 100, 125 and 150% of the recommended dose) in the plots and two sources of K (potassium chloride – KCl and potassium sulfate – K2SO4) in the subplots, with four replicates. The following characteristics were evaluated: transverse and longitudinal diameters, skin thickness, fruit weight, production per plant, pulp percentage, hydrogen potential (pH), soluble solid (SS), ascorbic acid (VIT C), titratable acidity (TA) and SS/TA ratio. The doses and sources of K applied through fertigation caused significant effect on fruit physical-chemical characteristics and production per plant in Tommy Atkins mango, particularly at the dose of 349 g plant-1 of K2SO4, which led to higher production per plant and guaranteed the minimum quality required for fruit physical-chemical characteristics.

627: The effect of lactation on long-term cardiovascular function

Epidemiological studies are inconsistent regarding the long-term maternal cardiovascular outcomes after pregnancy and lactation, especially when compared to never pregnant women. Moreover, human studies are confounded by many factors. Our objective was to investigate the effects of pregnancy and lactation on the long-term maternal vascular function in mice. 2-3 month old female B629SF2/J mice were bred and allowed to deliver. They were randomized into lactating (L, n=10-16) and non-lactating (NL, n=10-12) groups. At 6 months post partum, L and NL groups and age-matched virgins (VG, n=7-9) underwent blood pressure (BP) measurements via tail cuff. Mice were sacrificed, and carotid and mesenteric arteries were excised for in-vitro vascular reactivity studies using small vessel wire myograph. After a stabilization period, responses to single dose of potassium chloride (KCL, 60mmol/L) and concentration-response curves (CRC) to acetylcholine (Ach), sodium nitroprusside (SNP), isoproterenol (ISO), phenylephrine (PE) and thromboxane (TBX) were obtained. The BP measurements, maximal effect (Emax), and area under the curve (AUC) were analyzed using the 1-way ANOVA and Kruskal-Wallis test as appropriate (significance: P<0.05). At 6 months post partum, the L mice had significantly lower systolic, diastolic, and mean BP than both NL and VG groups (P=0.03 for all). BP measurements were lower in NL when compared to VG mice, though not significantly. Relaxation responses to SNP and ISO in carotid artery were significantly higher in L groups as compared to NL (SNP Emax P=0.03, AUC P<0.001; figure; ISO Emax P=0.01, AUC P=0.04) and to VG mice (SNP AUC P<0.001). These responses were not significantly different between NL and VG groups. All other comparisons were not significantly different. Pregnancy independently improves long term cardiovascular function, but the most benefit is derived when pregnancy is followed by lactation.

626: Pregnancy independently impacts long term maternal cardiovascular function

Normal pregnancy is associated with beneficial changes in cardiovascular function that persist long after delivery. Breastfeeding and oxytocin are also known to impact these pathways. Our objective was to determine the independent effect of pregnancy on long term maternal cardiovascular function using a transgenic mouse model with deficient lactation due to lack of the oxytocin gene (Oxt-/-). Virgin 3-4 month old female Oxt -/- mice were randomly assigned to breeding versus no breeding. Blood pressure (BP) was measured via tail cuff in mice that were 6 months post partum (PP group, n=10-16) and age-matched virgin mice (VG group, n=8-10). The animals were sacrificed, and carotid and mesenteric arteries were excised and placed in small vessel wire monographs for in-vitro vascular reactivity studies (VR). After a stabilization period, responses to single doses of potassium chloride (KCL, 60mmol/L) and concentration-response curves (CRC) to acetylcholine (Ach), sodium nitroprusside (SNP), isoproterenol (ISO), phenylephrine (PE) and thromboxane (TBX) were obtained. With the BP and CRC results, maximal effect (Emax) and area under the curve (AUC) were analyzed using Student T, Mann-Whitney Rank Sum, 1-way and 2-way ANOVA tests (significance: P<0.05). At 6 months post partum, the PP mice had significantly lower systolic, diastolic, and mean BP compared with age-matched VG mice (P=0.03 for all, Figure). Significantly lower contractile responses to PE and TBX in the mesenteric artery and to TBX in the carotid artery were noted in PP versus VG (Table). Significantly higher relaxation to ISO was noted in the mesenteric artery and to Ach and ISO in the carotid artery from PP compared with VG mice (Table). Pregnancy leads to beneficial effects on maternal cardiovascular function that persist long after delivery, and this effect is independent of oxytocin and lactation. Uncovering the mechanisms involved may lead to novel therapies to improve women's cardiovascular health.View Large Image Figure ViewerDownload Hi-res image Download (PPT)

Pineapple plantlets ‘Vitória’ fertilized with potassium chloride and silicic acid: growth and nutritional composition

The objective of this study was to evaluate the effect of silicon and potassium fertilization on the growth and nutrient content of pineapple plantlets ‘Vitoria’ obtained from in vitro cultivation. The experiment was conducted in a greenhouse from November 2013 to April 2014, totaling 150 days. The experimental design was randomized blocks, in a 4 x 2 factorial scheme, with four doses of potassium chloride (0, 1.25, 2.5 and 3.75 g L-1) with or without the application of silicic acid, with five replications of 12 plants each. The silicon concentration in pineapple plants ranged from 11.57 to 16.97 g kg-1, and an increase of 33% in the nutrient levels in plants fertilized with the lowest dose of potassium chloride was observed. It was observed that increasing doses of potassium chloride together with silicic acid resulted in lower root volumes in pineapple plantlets. Potassium accumulation of pineapple plantlets fertilized with silicic acid was lower than that of non-fertilized plantlets.

Soil salinity and yield of mango fertigated with potassium sources

ABSTRACT Irrigated fruit crops have an important role in the economic and social aspects in the region of the Sub-middle São Francisco River Valley. Thus, the aim of this study was to evaluate soil salinity and the productive aspects of the mango crop, cv. Tommy Atkins, fertigated with doses of potassium chloride (KCl) and potassium sulfate (K2SO4) during two crop cycles (from January to March 2014 and from January to March 2015). The experiment was carried out in a strip-split-plot design and five potassium doses (50, 75, 100, 125 and 150% of the recommended dose) as plots and two potassium sources (KCl and K2SO4) as subplots, with four replicates. Soil electrical conductivity (EC), exchangeable sodium (Na+) and potassium (K+) contents and pH were evaluated. In addition, the number of commercial fruits and yield were determined. The fertilization with KCl resulted in higher soil EC compared with K2SO4 fertigation. Soil Na+ and K+ contents increased with increasing doses of fertilizers. K2SO4 was more efficient for the production per plant and yield than KCl. Thus, under the conditions of this study, the K2SO4 dose of 174.24 g plant-1 (24.89 kg ha-1 or 96.8% of recommendation, spacing of 10 x 7 m) was recommended for a yield of 23.1 t ha-1 of mango fruits, cv. Tommy Atkins.

English

Noni has been introduced in Brazil just over a decade ago. Therefore, the information regarding crop fertilization and its influence on fruit quality is rare in the literature. Among macronutrients, potassium is highly concentrated in noni plants, and fertilization with cattle manure contributes to plant nutrition and fruit quality. This study sought to evaluate the effect of potassium fertilizer and cattle manure on the physical and physicochemical attributes of noni fruits. The treatments were distributed in randomized blocks, with four replications and two plants per plot, arranged in a factorial design 5 &times; 2 related to 0, 13.2, 37.5, 61.5 and 69.6 g plant-1 potassium chloride doses in soils without and with 12 kg plant-1 of cattle manure, with a C/N = 18:1 ratio. Cattle manure increased the average fruit weight from 99.6 to 113.4 g, expressing an increase of 13.9% for plants without and with organic compounds. Potassium chloride provided an increase of 61% in fruit weight and 31.25% in titratable acidity in fruits of plants without and with the highest dose of potassium chloride. Potassium chloride and cattle manure increased fruit mass, fruit length, fruit diameter, pulp mass, vitamin C and glucose contents in noni fruits. &nbsp; Key words: Fruit quality, Morinda citrifolia L., organic mineral fertilizer.

Erythrocytosis in a Patient with Type 1 Diabetes Mellitus and Concomitant Gitelman’s Syndrome

weakness (1). The association of GS and type 1 diabetes mellitus (DM) is rare, only described in a few case reports. Concomitant presence of GS and type 1 DM is a challenging situation for physicians as the treatment of hyperglycemia is complicated by hypokalemia (2). Furthermore, in case of diabetic ketoacidosis (DKA), management can be more difficult. Usually high doses of potassium chloride are needed to obtain normal serum potassium levels. If there is a treatment-resistant hypokalemia in a recent onset type 1 diabetic patient with DKA, one should consider the presence of associated tubulopathies (3). Both type 1 DM and Gitelman’s syndrome (GS) is characterized by hypokalemia, hypomagnesaemia, hypocalciuria, metabolic alkalosis, and neurological symptoms. The association of GS with type 1 diabetes is rare, described only in a few case reports. We report a patient with an unusual combination of GS and type 1 diabetes mellitus with erythrocytosis. A 26-year-old male with GS and type 1 diabetes, who was on intensive insulin therapy with poor compliance, presented with the complaint of headache. On physical examination, his blood pressure was 120/70 mmHg and there was no neurological deficit or proximal muscle weakness. He had no previous medical history of obstructive sleep apnea, heart or lung disease. He had negative smoking history. His laboratory tests revealed erythrocytosis with a hemoglobin level of 18.9 g/dL (13.6-17.2 g/dL) and a hematocrit level of 54.8% (39.5-50.3%). Cranial magnetic resonance imaging was normal. He had no evidence of hypovolemia. Hematological workout excluded polycythemia vera and chronic myeloid neoplasm. A bone marrow aspiration revealed a hypercellular marrow with increased erythroid precursors, megakaryocytes and granulocytes. The reticulin stain grade was zero. There was no iron accumulation with iron stain. There was no radiologic evidence of any kind of erythropoietin-producing tumors. His echocardiography was normal. Serum insulin-like growth factor-1 levels and endogenous androgens were within normal limits. After 2 therapeutic phlebotomies, his symptoms improved and his hemoglobin was 16.1 mg/dL. Our patient, besides having GS and type 1 diabetes, was complicated with idiopathic erythrocytosis, all having deleterious effects on hemodynamic status of the patient.

Phosphorus and potassium fertilization in culture of soybean plants in the Oxisol

It is recommended to use phosphorus and potassium fertilization on soybean; however it has been common to verify the absence of effect on crop productivity, especially in no-tillage system. Thus, the study aimed to evaluate the effect of doses of superphosphate and potassium chloride in the leaf tissue nutrient content and yield of soybean growing in Oxisol. The experiment was installed in October 2011 in a randomized block design in split-bands with two factors (4x4), with four replications, totaling 64 plots, being Factor 1 with doses of superphosphate (0, 136, 331 and 700 kg ha-1) at sowing and Factor 2 with doses of potassium chloride (0, 160, 320 and 800 kg ha-1) released with cultivar Vmax RR (SYN 7059RR). In the experiment, the variables evaluated were Ca, Mg, K, P, S, Cu, Zn, Mn and Fe in leaf tissue and grain yield. The fertilization with superphosphate and potassium chloride do not interfere in leaf nutrient content and yield of soybean cultivar Vmax RR (SYN 7059RR) grown on an Oxisol of clayey with levels of P and K classified as high. In these cases, it is advisable to keep only the maintenance fertilization according to the values ​​of P and K exported by grain. Key words: Chemical fertilizer, tillage systems, organic mineral fertilizer, superphosphate, potassium chloride.

Cloreto de potássio revestido em efeito residual no feijoeiro de inverno irrigado na região de cerrado

In order to maintain the nutrients available to plants have been studied controlled release fertilizers. In this context, the objective was to evaluate the residual effect of doses of potassium chloride, coated or not, applied in the corn crop, regarding the crop components and grains yield of irrigated winter common bean, cultivated in followed, in Cerrado region. The experiment was conducted in Selviria – MS, Brazil, 51°22’ west longitude and 20°22’ south latitude, in a clayey Oxisol, in 2009 and 2010. A randomized block design with four repetitions was used, disposed in a factorial scheme 4 x 2, being: four K2O doses (0, 40, 80 and 120 kg ha-1) and two potassium sources (potassium chloride and coated potassium chloride by polymers) applied at sowing in the corn crop. The coated potassium chloride by polymers have the same residual effect as conventional KCl, because it provides results similar for the K and chlorophyll leaf contents, crop components and grains yield of winter common bean irrigated. The increment of potassium doses in the previous crop (corn) have residual effect, because it influenced positively the number of grains per plant in 2009 and increased linearly the chlorophyll leaf content and the grains yield of winter common bean irrigated in 2010, regardless of the source used for K.

Efeito da adubação potássica no crescimento do feijão de corda preto

The bean is a plant nutrient and quite demanding, because it has a short life cycle, they need readily available in times of demand, not to limit productivity. Since the importance of fertilizing the objective of this study was to evaluate the effects of increasing doses of potassium in the initial development of string bean black. The experiment was conducted in an area belonging to FATEC Cariri, Juazeiro CE, using five potassium fertilizer levels (0, 8.5, 17, 22.5 and 34 kg ha -1 of potassium chloride) and three sampling times, composing a split plot with three replications. Doses of potassium chloride applied and the collection time significantly affected the stem height; responses of the variables were adjusted significantly to the model school for the doses of potassium chloride in stem height and the linear model for times collections in height and stem diameter.

Dofetilide Overdose—A Case of Unintentional Ingestion Due to Misinterpretation of the Dose

Objective: To report a case of unintentional overdose of dofetilide due to patient misinterpretation of the prescribed dose. Case Summary: A 50-year-old white male unintentionally ingested dofetilide 5000 μg instead of the prescribed dose of 500 μg because of a simple mathematical calculation error. The patient was given activated charcoal in the emergency department and also received 1 dose of magnesium sulfate 2 g and 1 dose of potassium chloride 80 mEq by mouth. He was admitted to the intensive care unit for cardiac monitoring for 1 day and was discharged when his QT/QTc interval was stable. Discussion: During recent years, studies have focused on errors that occur while medications are in the control of health care professionals. As health care delivery shifts from inpatient to outpatient settings, the burden of proper medication use also shifts from providers to patients. Low health literacy and lack of understanding of instructions have been cited as important root causes of medication errors in the outpatient setting. Effective communication with patients who have limited health literacy offers the potential to improve their understanding about their medical problems and treatments. Dofetilide, a class III antiarrhythmic agent, is highly regulated due to safety concerns. The drug is efficacious in the maintenance of normal sinus rhythm in patients with atrial fibrillation. Cardiac toxicity is of utmost concern when treating dofetilide overdose. The mainstay of treatment focuses on supportive care and prevention of drug absorption. Conclusions: Medication errors will not cease to occur unless patients understand their dosing instructions and health care responsibilities. This case highlights the need for the monitoring of patient understanding, especially when drugs with high safety risk are being used.

DOSES DE POTÁSSIO NA PRODUÇÃO DE MUDAS DE UVAIA

With the objective to evaluate the development of uvaia using potassium chloride, this experiment was installed in the Sector of Fruticultura of the Federal University of Lavras, with four doses of potassium chloride (0; 1,0; 2,0; 4,0 kg m-3). After 90 days of the sowing, the following data had been collected: average height of the aerial part and root (cm); average leaf number; average dry mass of the root and the aerial part (g). They had been found resulted significant for length of the aerial part, length of root. The KCl promoted good results in production of uvaia changes.

Apparent seizure and atrial fibrillation associated with paliperidone

A case of apparent seizure and atrial fibrillation associated with paliperidone is reported. A 46-year-old man arrived at the emergency room (ER) via ambulance. Earlier that morning, his wife observed him awakening in a panic, drifting back to sleep, and then subsequently awakening in a panic with an apparent seizure lasting one to two minutes. The episode included tongue biting and urinary incontinence. His medical history included bipolar disorder, diabetes mellitus, hyperlipidemia, and hypertension. The patient's medications included metformin, insulin glargine, insulin lispro, simvastatin, enalapril, escitalopram, lamotrigine, and clonazepam and had not changed for many months except for the recent addition of paliperidone four days before his arrival at the ER. Electrocardiography revealed atrial fibrillation, a ventricular rate of 151 beats/min, a Q-Tc interval of 461 msec, and no significant changes in the ST segment or T wave. He had no chest pain, and all other laboratory test results and vital signs were normal. The patient was admitted for evaluation and given a single oral dose of potassium chloride. Diltiazem i.v. was administered with resultant conversion to normal sinus rhythm, after which the patient's heart rate and Q-Tc interval normalized. The patient was discharged after one day. A man taking paliperidone and multiple other drugs experienced atrial fibrillation and a possible seizure. Although these are known adverse effects of atypical antipsychotics, it is unusual to have both events occur concurrently and with low-to-average dosages, and these events have not been associated with paliperidone in published case reports.

Efeito de doses de potássio e da freqüência de irrigação na produção da alface-americana em ambiente protegido

A produção da alface tipo americana em ambiente protegido, aliada ao emprego de práticas de manejo de irrigação e adubação, pode contribuir para o aumento da produtividade e expansão da cultura na região de Lavras - MG. Em uma estufa modelo capela, foi realizado um experimento com o objetivo de avaliar o efeito de freqüências de irrigação e de doses de potássio sobre a produtividade da alface-americana e a eficiência do uso da água. O experimento foi composto pelos seguintes tratamentos de turnos de rega: (P1) - irrigação diária; (P2) - irrigação de dois em dois dias; (P3) - irrigação de três em três dias, e (P4) - irrigação de quatro em quatro dias. Nas parcelas subdivididas, foram aplicadas quatro doses de cloreto de potássio, via fertirrigação: (D1) - 100 kg de KCl ha-1; (D2) - 150 kg de KCl ha-1; (D3) - 200 kg de KCl ha-1, e (D4) - 250 kg de KCl ha-1. As variáveis avaliadas foram a produtividade de alface e a eficiência do uso da água, ou seja, a produtividade por milímetro de água aplicado. Concluiu-se que a maior produtividade (44,06 t ha-1) foi obtida com 119,36 kg ha-1 de K2O; o manejo de irrigação para a cultura da alface-americana em ambiente protegido poderá ser realizado com intervalo entre irrigações de quatro dias, e com o aumento dos intervalos houve aumento da eficiência de uso da água de irrigação.

Causation, Intention, and Active Euthanasia

Mr. Paul Mills suffered from cancer of the esophagus (the passage between the mouth and the stomach). Three major surgeries were unsuccessful in correcting the problem, and other treatment methods likewise failed. His condition deteriorated to the point where there was no longer any hope of recovery. Dr. Morrison, who was Mr. Mills's intensive care physician at the Queen Elizabeth II Health Sciences Centre in Halifax, and Mr. Mills's family (Mr. Mills was incompetent by this time) agreed that active life support should be discontinued. Dr. Morrison then removed Mr. Mills's ventilator. To everyone's surprise, and dismay, Mr. Mills did not die. He continued to breathe spontaneously and started to show signs of distress. Dr. Morrison increased the dosage of morphine, to no effect. She increased it again to the point where death could reasonably be expected to occur; signs of distress continued. Dr. Morrison at this point administered a dose of potassium chloride and Mr. Mills died.I am grateful to Don Brown for very helpful comments and conversation.

A new oral therapy for long QT syndrome: Long-term oral potassium improves repolarization in patients with HERGmutations

ObjectivesWe sought to determine whether oral potassium supplementation safely increases serum K+and results in sustained improvement of repolarization parameters in long QT syndrome type 2 (LQT2) subjects. BackgroundMutations in HERG(LQT2), the gene encoding the rapid delayed rectifier K+current IKr, account for a significant proportion of congenital long QT syndrome (LQTS). The magnitude of IKris paradoxically increased by an increase in extracellular K+. We tested the hypothesis that long-term oral potassium supplementation results in a mild, sustainable increase in serum K+that improves repolarization abnormalities in subjects with LQT2. MethodsAfter an initial evaluation consisting of electrocardiography, electrolytes, blood urea nitrogen, and creatinine, escalating doses of potassium chloride (KCl) and spironolactone were administered to eight subjects with six distinct HERGmutations. Medications were continued for four weeks, at which time, the final evaluation was undertaken. Beta-adrenergic blocking therapy was maintained. ResultsThe subjects ranged in age from 11 to 52 years. The average daily KCl and spironolactone dose was 3.3 ± 1.5 mEq/kg and 3.5 ± 1.2 mg/kg, respectively, and this regimen resulted in an increase in serum K+from 4.0 ± 0.3 to 5.2 ± 0.3 mEq/l. There were no serious complications associated with therapy. The increase in serum K+resulted in a decrease in the corrected QT interval from 526 ± 94 to 423 ± 36 ms (mean ± SD; lead V2). Both QT dispersion and T-wave morphology improved in most subjects. ConclusionsLong-term oral potassium administration increases serum K+in patients with LQT2. This can be achieved safely and results in improvement in repolarization. Further studies are warranted to determine whether this will reduce the incidence of life-threatening events in LQTS patients.