Donation Banking Research Articles

An exploratory study on the linkage plan of social contribution activities donation bank caring activities with college students majoring in social welfare for the prevention of lonely death in the elderly

An exploratory study on the linkage plan of social contribution activities donation bank caring activities with college students majoring in social welfare for the prevention of lonely death in the elderly

Effect of the Elderly's Change of Life on the Satisfaction of Care Service through the Donation Bank of Social Contribution Activities : Focusing on the Mediating Effect of Social Integration

Effect of the Elderly's Change of Life on the Satisfaction of Care Service through the Donation Bank of Social Contribution Activities : Focusing on the Mediating Effect of Social Integration

Supporting difficult times by leave donation program

To promote the spirit of sharing is caring, organizations these days have started with a very employee friendly program called Voluntary Leave Donation/Sharing Program. This program enables employees affected by some medical emergency or crisis situation and who have exhausted their own paid leave quota can receive leave donations from fellow employees. Leave pooling brings in certain benefits to the work place like increased bonding amongst employees, reduced turnover and more flexibility in work environment. To avail leave from leave donation bank, employee has to follow a proper procedure prescribed by the employer. Proper agency should administer the voluntary leave donation program to prevent leave abuse and to make it a successful leave option/initiative.

Simultaneous Occurrence of Neonatal Alloimmune Thrombocytopenia and Neutropenia Associated with Multiple Maternal Antibodies

Background: Neonatal alloimmune thrombocytopenia (NAIT) results from feto-maternal platelet antigen incompatibility leading to the production of maternal antibodies and destruction of fetal platelets during pregnancy. Similarly neonatal alloimmune neutropenia (NAN) is caused by maternal alloimmunization to incompatible fetal neutrophil antigens followed by transplacental transfer of the maternal anti-neutrophil antibody causing fetal or neonatal neutropenia. Although there are many reports in the literature describing these rare disorders, the simultaneous occurrence of NAIT and NAN has not been systematically evaluated. In this study we report a case of NAIT associated with NAN.Material and Methods: A healthy 46-year-old primiparous woman gave birth to triplets in the 30.9th gestational week, by C-section, after a fertility treatment using an egg donation banking. The first neonate, a 1,600g female newborn with a first/fifth minute Apgar score of 8/9, healthy at physical examination, showed severe thrombocytopenia (platelet count = 30x109/L) and a neutrophil count of 1.6X109/L at birth. The second neonate, a 1,275g male newborn had a first/fifth minute Apgar score of 7/7, was healthy at physical examination and showed thrombocytopenia (platelet count = 82x109/L) and neutropenia (neutrophil count = 0.66x109/L). Intracranial bleeding, perinatal infections, genetic and hematologic disorders were ruled out and the neonates showed a spontaneously normalization of the platelets and neutrophils counts. Unfortunately, blood sample from the third neonate, a 1,525g female newborn with first/fifth minute Apgar score of 9/9, was not available. Mother and neonates were genotyped for platelets antigens (HPA-1-11,-15) and neutrophil antigens (HNA-1,-3). HPA genotyping was performed by PCR-SSP, PCR-RFPL and xMAP technology (IDHPAXT, Progenika-Grifols, Spain). HNA genotyping was performed by PCR-SSP and PCR-RFPL. Platelets antibodies were investigated in maternal serum by platelet enzyme-linked immunosorbent assay (PaK12G, Immucor GTI Diagnostic Inc, USA); neutrophil antibodies were investigated by granulocyte agglutination test (GAT) using a panel of donors previously genotyped for HNA-1,-3 systems, while anti-HLA antibodies were investigated by ELISA (LAT Mixed, One Lambda Inc., USA and PaK12G, Immucor GTI Diagnostic Inc, USA).Results: Genotyping studies revealed mismatches for HPA-1,-5 and HNA-1,-3 systems between mother and neonates (Table1). Serologic antibody screening tests showed presence of anti-HPA-5b, anti-HNA-3b and anti-HLA in maternal serum. TABLE 1GENOTYPING RESULTSHPA-1HPA-5HNA-1HNA-3MOTHERHPA-1a1aHPA-5a5aHNA-1a1aHNA-3a3aNEONATE 1HPA-1b1bHPA-5a5bHNA-1b1bHNA-3a3bNEONATE 2HPA-1b1bHPA-5a5bHNA-1b1bHNA-3a3aConclusion: We described the occurrence of NAIT associated with NAN in preterm neonates with important thrombocytopenia and neutropenia due a multiple maternal sensitization to incompatible fetal antigens. As these syndromes pose a risk to the neonate’s life, the early and correct diagnosis is very important in order to apply appropriate treatment to the neonates and allow an effective prenatal therapy for future pregnancies. DisclosuresNo relevant conflicts of interest to declare.

Developing a smartphone app to enhance Oxfam's supply chain visibility

This paper reports on the development of a smartphone app designed to give drivers and managers in a charity organisation greater visibility of transport, donation bank and shop stock in time and space. Trials of the app with samples of drivers and shop managers across three counties in the UK showed that users' understanding of vehicle activity and how time was utilised in the business was enhanced. The app also informed their decision-making, aided some collaboration and helped in their understanding of donation bank and shop performance, with one region altering their collection schedules. The quality of 3G signal was an issue in certain areas which impeded performance and the rules by which the messaging platform should be used in such a tool need careful consideration.

Tg-SwDI Transgenic Mice Exhibit Novel Alterations in AβPP Processing, Aβ Degradation, and Resilient Amyloid Angiopathy

Alzheimer's disease (AD) is characterized by the accumulation of extracellular insoluble amyloid, primarily derived from polymerized amyloid-beta (Abeta) peptides. We characterized the chemical composition of the Abeta peptides deposited in the brain parenchyma and cerebrovascular walls of triple transgenic Tg-SwDI mice that produce a rapid and profuse Abeta accumulation. The processing of the N- and C-terminal regions of mutant AbetaPP differs substantially from humans because the brain parenchyma accumulates numerous, diffuse, nonfibrillar plaques, whereas the thalamic microvessels harbor overwhelming amounts of compact, fibrillar, thioflavine-S- and apolipoprotein E-positive amyloid deposits. The abundant accretion of vascular amyloid, despite low AbetaPP transgene expression levels, suggests that inefficient Abeta proteolysis because of conformational changes and dimerization may be key pathogenic factors in this animal model. The disruption of amyloid plaque cores by immunotherapy is accompanied by increased perivascular deposition in both humans and transgenic mice. This analogous susceptibility and response to the disruption of amyloid deposits suggests that Tg-SwDI mice provide an excellent model in which to study the functional aftermath of immunotherapeutic interventions. These mice might also reveal new avenues to promote amyloidogenic AbetaPP processing and fundamental insights into the faulty degradation and clearance of Abeta in AD, pivotal issues in understanding AD pathophysiology and the assessment of new therapeutic agents.