Dominance Period Research Articles

Clinical outcomes of immunomodulation therapy in immunocompromised patients with severe Covid-19 and high oxygen requirement

Covid-19 disease is implicated in increased mortality among immunocompromised patients. The JAK inhibitor, baricitinib (bar), or the IL-6 inhibitor, tocilizumab (toc), demonstrated a survival benefit in patients with severe disease.However, evidence supporting their use in immunocompromised patients with severe Covid-19 is scarce.We aimed to assess clinical outcomes of bar/toc treatment in immunocompromised patients. A multi-center registry of consecutive immunocompromised patients hospitalized due to severe Covid-19 during the Omicron variant dominance period. After excluding patients who did not require high oxygen supply, patients treated with bar/toc were compared to patients treated by standard of care (SOC). Primary outcome was in hospital mortality. Secondary outcomes were 30 and 60 day mortality, super-infection and thromboembolic events. Among an overall 228 immunocompromised patients hospitalized in six Israeli hospitals with severe Covid-19, 112 patients required high oxygen support, of whom 48 (43%) were treated with bar/toc. In-hospital mortality rates were exceptionally high and did not significantly differ between bar/toc and SOC treated patients (62.5% vs. 64.1%, p = 1.0). A logistic regression analysis revealed that advanced age and incomplete vaccination were predictors of in-hospital mortality. Patients treated with bar/toc had no excess of suspected super-infection (62.8% vs. 60.7%, p = 0.84) or thromboembolic events (8.3% vs 3.1%, p = 0.39). In immunocompromised patients with severe Covid-19 and a high oxygen demand, bar/toc therapy was not associated with reduced mortality or with a higher rate of associated complications, compared to SOC. Larger prospective studies should better address efficacy and safety.

Effectiveness of azvudine against severe outcomes among hospitalized COVID-19 patients in Xinjiang, China: a single-center, retrospective, matched cohort study

ABSTRACT Background Since the end of 2022, Azvudine was widely used to treat hospitalized coronavirus disease 2019 (COVID-19) patients in China. However, data on the real-world effectiveness of Azvudine against severe outcomes and post-COVID-19-conditions (PCC) among patients infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variants was limited. This study evaluates the effectiveness of Azvudine in hospitalized COVID-19 patients during a SARS-CoV-2 Omicron BA.5 dominance period. Methods From 1 November 2022 to 1 July 2023, an SARS-CoV-2 Omicron BA.5 dominant period, we conducted a single-center retrospective cohort study based on hospitalized patients with laboratory-confirmed SARS-CoV-2 infection from a tertiary hospital in Shihezi, China. Patients treated with Azvudine and usual care were propensity-score matched (PSM) at a 1:1 ratio to a control group in which patients received usual care only, with matching based on covariates such as sex, age, ethnicity, number of preexisting conditions, antibiotic use at admission, and baseline complete blood cell count. The primary outcomes were all-cause death and short-term (60 days) PCC post discharge. The secondary outcomes included the initiation of invasive mechanical ventilation and PCC at long-term post discharge (120 days). Cox proportional hazards (PH) regression models were employed to estimate the hazard ratios (HR) of Azvudine treatment for both all-cause death and invasive mechanical ventilation, and logistic regression models were used to estimate the odds ratios (OR) for short-term and long-term PCC. Subgroup analyses were performed based on a part of the matched covariates. Results A total of 2,639 hospitalized patients with SARS-CoV-2 infection were initially identified, and 2,069 ineligible subjects were excluded from analyses. After matching, 297 Azvudine recipients and 297 matched controls were eligible for analyses. The incidence rate of all-cause death was relatively lower in the Azvudine group than in control group (0.007 per person, 95% confidence interval [CI]: 0.001, 0.024 vs 0.128, 95% CI: 0.092, 0.171), and the use of Azvudine was associated with a significantly lower risk of death (HR: 0.049, 95% CI: 0.012, 0.205). Subgroup analyses suggested protection of Azvudine against the risks of all-cause death among men, age over 65, patients without the preexisting conditions, and patients with antibiotics dispensed at admission. Statistical differences were not observed between the Azvudine group and the control group for the risks of invasive mechanical ventilation or short and long-term PCC. Conclusions Our findings indicated that Azvudine was associated with lower risk of all-cause death among hospitalized patients with Omicron BA.5 infection in a real-world setting. Further investigation is needed to explore the effectiveness of Azvudine against the PCC after discharge.

#477 Risk factors for the mortality among hemodialysis patients with COVID-19 infection in 28 hemodialysis centers, South Korea

Abstract Background and Aims Understanding mortality risk factors in hemodialysis patients with COVID-19 is critical for effective management. This study aimed to identify the factors influencing mortality risk and to evaluate the efficacy of COVID-19 vaccines in this specific population. Method This retrospective study analyzed clinical data from patients with COVID-19 who underwent hemodialysis at 28 affiliated centers of the Yeolin Medical Foundation between January 2020 and December 2022. Risk factors contributing to mortality were assessed through comparative analysis between survivors and deceased patients using R statistics. Results Of the 1,983 (ive study analyzed clinical data from patients with COVID-19 who underwent hemodialysis at 28 affiliated centers of the Yeolin analysis comparing survivors and deceased individuals revealed significant associations between mortality risk and several factors such as the omicron dominance period, age om patients with COVID-19 who underwent hemodialysis at 28 affiliated centers of tation, except for one dose, showed a decreasing trend in mortality risk with increasing doses. In the multivariable analysis, age ≥65 years(OR 1.04;95% CI[1.00 - 1.09],p=0.028), dyspnea(OR1.13;95% CI [1.07 - 1.19],p<0.001), and multiple doses of COVID-19 vaccination{2 doses(OR 0.91;CI[0.86 - 0.96],p=0.001), 3 doses(OR 0.88;CI[0.84- 0.92],p<0.001), 4 doses(OR 0.88;CI [0.84 - 0.93],p<0.001), 5 doses(OR 0.87;CI[0.81 - 0.93],p<0.001)} retained significance. Mortality did not appear to be significantly affected by sex, duration of ESRD, BMI, pneumococcal vaccination status, type and total number of comorbidities, or use of immunosuppressants. Conclusion Hemodialysis patients with COVID-19 infection have a high mortality rate per se, and comorbidity had no effect on mortality. Age(>65) and dyspnea were associated with higher mortality rates, and the lower ORs with increasing number of vaccines suggest that vaccination is a crucial protective factor in dialysis patients.

Trends of Hepatitis A Virus Infection in Poland: Assessing the Potential Impact of the COVID-19 Pandemic and War in Ukraine.

Hepatitis A virus (HAV) is the most common cause of acute viral hepatitis, which is preventable by vaccination. This study analyzed trends of HAV infections in Poland according to socio-demographic features in the years 2009-2022 and assessed the potential impact of the COVID-19 pandemic (2020-2023) and the migration of war refugees from Ukraine (since February 2022). In 2009-2022, 7115 new cases of HAV infection were diagnosed in Poland, especially among men (66.4%) and in urban areas (77.4%). Infections among men were most common at the age of 25-34 (median rate 0.43 per 105) and in women aged 15-24 (median rate 0.39 per 105). Analysis of the 14-year frequency of HAV infections exhibited three trends, regardless of gender, age, and residence. The infections revealed a downward trend in 2009-2014, increased significantly in 2014-2018, and decreased again after 2018. A particularly rapid increase in HAV infections occurred between March 2017 and February 2018 (median rate 0.79 per 105). The high level of new infections persisted until the beginning of the COVID-19 pandemic, at which point it dropped significantly but did not reach the level recorded before March 2017. During the Omicron SARS-CoV-2 dominance period, the median rate of HAV infections was 0.053 per 105, with a four-fold increase being observed from February 2022 (when the migration of war refugees from Ukraine began) to August 2022. The presented results can serve as a reference point for further observations in Central Europe. The HAV epidemiological situation is unlikely to escalate in Poland but requires further monitoring.

Social and economic determinants of electoral behavior in Turkey

PurposeIn this study the authors aim to comprehensively investigate the determinants of voting behavior in Turkey, with a specific focus on the dynamics of the center-periphery debate. Mainly, the authors focus on regional voting patterns during the period that is dominated by the Justice and Development Party (JDP/AKP) in the elections. The authors apply the random effects generalized least squares (GLS) methodology, and analyze electoral data covering four pivotal parliamentary elections (2007, 2011, 2015 and 2018) across all 81 provinces (NUTS III regions). The authors individually examine voting dynamics of the four major parties in parliament: the JDP/AKP, the Republican People's Party (RPP/CHP), the Nationalist Movement Party (NMP/MHP) and the Peoples' Democratic Party (PDP/HDP). The authors contribute to a comprehensive understanding of how socioeconomic cleavages, economic performance, party alignment and social dynamics shape voter preferences in the Turkish context, thereby addressing gaps in the existing literature.Design/methodology/approachThis research employs an ecological study of Turkish NUTS III sub-regions, covering national elections from 2007 to 2018. The authors utilize the random effects GLS method to account for heteroscedasticity and time effects. The inclusion of the June and November 2015 elections enables a comprehensive analysis of the evolving dynamics in Turkish voting behavior. The results remain robust when applying pooled OLS and fixed effect OLS techniques for control.FindingsThe study's findings reveal that economic performance, specifically economic growth, plays a pivotal role in the sustained dominance of the JDP/AKP party. Voters closely associate JDP preference with economic growth, resulting in higher voting shares during periods of economic prosperity. Along with economic growth; share of agriculture in regions' GDP, female illiteracy rate, old population rate, net domestic migration, terrorism and party alignment are also influential factors in the Turkish case. Furthermore, differences among sociocultural groups, and East–West dichotomy seem to be important factors that reveal the impact of social cleavages to understand electoral choice in Turkey.Originality/valueThis study contributes to the existing literature by offering a comprehensive multidimensional analysis of electoral behavior in Turkey, focusing on the JDP/AKP dominance period. The main contribution of this study is its multidimensional perspective on the power bases of all main parties, considering key voter choice theories (cleavages, party alignment and retrospective economic performance voting) that have not been systematically analyzed in prior research. The main research question of this study is to examine which factors affect voting behavior in Turkey and how the dynamics of center-periphery or eastern-western region voting behavior under the JDP hegemony can be explained. The contribution of this study consists not only in its empirical testing of panel data approaches but also in its comprehensive analysis of four major political parties. Building upon existing studies in the literature, this research seeks to extend the understanding of voting dynamics for the four main parties in the parliament — JDP/AKP, RPP/CHP, NMP/MHP and PPDP/HDP — by delving into their dynamics individually, thereby expanding the scope of previous studies. This study aims to make a contribution by not only empirically testing panel data approaches but also conducting a comprehensive analysis of four major political parties. Furthermore, the separate inclusion of the 2015 elections and utilization of a panel data approach enrich the analysis by capturing the evolving dynamics of Turkish voting behavior. The study underscores the significance of socioeconomic factors, economic performance and social cleavages for voters' choices within the context of a dominant party rule.

The Impact of Vaccination against SARS-CoV-2 on Health Outcomes and Hospital Visits after Omicron Infection in Children and Adolescents Aged 5-18 Years: A Danish Nation-Wide Cohort Study.

This study investigates the impact of vaccination against SARS-CoV-2 on health outcomes and hospital contacts in children and adolescents aged 5-18 years infected with the SARS-CoV-2 Omicron variant, comparing previously vaccinated with unvaccinated. Using national register data, vaccinated and unvaccinated Danish children and adolescents with a positive SARS-CoV-2 test between 1 January and 31 March 2022 (Omicron dominance period) were included. The Prior Event Rate Ratio (PERR) was used to explore differences in hospital contacts (hospitalizations and emergency room (ER) visits), while Inverse Treatment Probability Weighted (IPW) risk ratios were used to explore the risk of severe health outcomes within six weeks following SARS-CoV-2 infection. Vaccinated 5-11-year-old girls had fewer visits to the ER compared to unvaccinated ones, PERR 0.92 (95% CI 0.84-1.00). Vaccinated 5-11-year-old boys had fewer hospitalizations (PERR 0.79 (0.64-0.99)) and more ER visits (PERR 1.13 (1.04-1.22)) compared to unvaccinated ones. An unadjusted and significant lower risk of febrile seizure among vaccinated 5-11-year-olds compared to unvaccinated ones was found (risk ratio 0.12 (0.04-0.39), p ≤ 0.01. No significant differences were found for severe conditions or for croup or pneumonia in either age group. The results indicate a modest protective effect of the vaccine in terms of hospital contacts, but no protective effect on health outcomes after SARS-CoV-2 Omicron infection in this population of Danish children and adolescents.

COVID-19 Epidemiology during Delta Variant Dominance Period in 45 High-Income Countries, 2020-2021.

The SARS-CoV-2 Delta variant, first identified in October 2020, quickly became the dominant variant worldwide. We used publicly available data to explore the relationship between illness and death (peak case rates, death rates, case-fatality rates) and selected predictors (percentage vaccinated, percentage of the population >65 years, population density, testing volume, index of mitigation policies) in 45 high-income countries during the Delta wave using rank-order correlation and ordinal regression. During the Delta-dominant period, most countries reported higher peak case rates (57%) and lower peak case-fatality rates (98%). Higher vaccination coverage was protective against peak case rates (odds ratio 0.95, 95% CI 0.91-0.99) and against peak death rates (odds ratio 0.96, 95% CI 0.91-0.99). Vaccination coverage was vital to preventing infection and death from COVID-19 during the Delta wave. As new variants emerge, public health authorities should encourage the uptake of COVID-19 vaccination and boosters.

New insights into binocular rivalry from the reconstruction of evolving percepts using model network dynamics.

When the two eyes are presented with highly distinct stimuli, the resulting visual percept generally switches every few seconds between the two monocular images in an irregular fashion, giving rise to a phenomenon known as binocular rivalry. While a host of theoretical studies have explored potential mechanisms for binocular rivalry in the context of evoked model dynamics in response to simple stimuli, here we investigate binocular rivalry directly through complex stimulus reconstructions based on the activity of a two-layer neuronal network model with competing downstream pools driven by disparate monocular stimuli composed of image pixels. To estimate the dynamic percept, we derive a linear input-output mapping rooted in the non-linear network dynamics and iteratively apply compressive sensing techniques for signal recovery. Utilizing a dominance metric, we are able to identify when percept alternations occur and use data collected during each dominance period to generate a sequence of percept reconstructions. We show that despite the approximate nature of the input-output mapping and the significant reduction in neurons downstream relative to stimulus pixels, the dominant monocular image is well-encoded in the network dynamics and improvements are garnered when realistic spatial receptive field structure is incorporated into the feedforward connectivity. Our model demonstrates gamma-distributed dominance durations and well obeys Levelt's four laws for how dominance durations change with stimulus strength, agreeing with key recurring experimental observations often used to benchmark rivalry models. In light of evidence that individuals with autism exhibit relatively slow percept switching in binocular rivalry, we corroborate the ubiquitous hypothesis that autism manifests from reduced inhibition in the brain by systematically probing our model alternation rate across choices of inhibition strength. We exhibit sufficient conditions for producing binocular rivalry in the context of natural scene stimuli, opening a clearer window into the dynamic brain computations that vary with the generated percept and a potential path toward further understanding neurological disorders.

Characteristics and outcomes of COVID-19 patients during B.1.1.529 (Omicron) dominance compared to B.1.617.2 (Delta) in 89 German hospitals

BackgroundThe SARS-CoV-2 variant B.1.1.529 (Omicron) was first described in November 2021 and became the dominant variant worldwide. Existing data suggests a reduced disease severity with Omicron infections in comparison to B.1.617.2 (Delta). Differences in characteristics and in-hospital outcomes of COVID-19 patients in Germany during the Omicron period compared to Delta are not thoroughly studied. ICD-10-code-based severe acute respiratory infections (SARI) surveillance represents an integral part of infectious disease control in Germany.MethodsAdministrative data from 89 German Helios hospitals was retrospectively analysed. Laboratory-confirmed SARS-CoV-2 infections were identified by ICD-10-code U07.1 and SARI cases by ICD-10-codes J09-J22. COVID-19 cases were stratified by concomitant SARI. A nine-week observational period between December 6, 2021 and February 6, 2022 was defined and divided into three phases with respect to the dominating virus variant (Delta, Delta to Omicron transition, Omicron). Regression analyses adjusted for age, gender and Elixhauser comorbidities were applied to assess in-hospital patient outcomes.ResultsA total cohort of 4,494 inpatients was analysed. Patients in the Omicron dominance period were younger (mean age 47.8 vs. 61.6; p < 0.01), more likely to be female (54.7% vs. 47.5%; p < 0.01) and characterized by a lower comorbidity burden (mean Elixhauser comorbidity index 5.4 vs. 8.2; p < 0.01). Comparing Delta and Omicron periods, patients were at significantly lower risk for intensive care treatment (adjusted odds ratio 0.72 [0.57–0.91]; p = 0.005), mechanical ventilation (adjusted odds ratio 0.42 [0.31–0.57]; p < 0.001), and in-hospital mortality (adjusted odds ratio 0.42 [0.32–0.56]; p < 0.001). This also applied mostly to the separate COVID-SARI group. During the Delta to Omicron transition, case numbers of COVID-19 without SARI exceeded COVID-SARI for the first time in the pandemic’s course.ConclusionPatient characteristics and outcomes differ during the Omicron dominance period as compared to Delta suggesting a reduced disease severity with Omicron infections. SARI surveillance might play a crucial role in assessing disease severity of future SARS-CoV-2 variants.

Impact of vaccination and the omicron variant on COVID-19 severity in pregnant women

We compared the clinical course of pregnant women with coronavirus disease 2019 (COVID-19) before and after the emergence of the omicron variant and based on vaccination status. We retrospectively reviewed the electronic medical charts of 224 patients and 82 deliveries from November 1, 2020, to March 7, 2022; of these, 42% were diagnosed during the omicron dominance period. Disease severity and morbidity of COVID-19 were significantly decreased during the omicron era. The vaccination rates among the patients were higher after omicron emergence (31.9%) than before (6.9%). Overall, 4.1% and 25% of patients had severe symptoms, and 2.6% and 16.2% required oxygen therapy in the vaccination and non-vaccination groups, respectively. Overall, patients had a more favorable clinical course in the omicron era; moreover, vaccinated patients were better protected than non-vaccinated patients, indicating the importance of vaccination against COVID-19.

Delta Variant of SARS-CoV-2 Replacement in Brazil: A National Epidemiologic Surveillance Program.

Coronavirus disease 2019 (COVID-19) pandemic has caused immeasurable impacts on the health and socioeconomic system. The real-time identification and characterization of new Variants of Concern (VOCs) are critical to comprehend its emergence and spread worldwide. In this sense, we carried out a national epidemiological surveillance program in Brazil from April to October 2021. Genotyping by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and sequencing were performed to monitor the dynamics and dissemination of VOCs in samples from 15 federative units. Delta VOC was first detected on June 2021 and took sixteen weeks to replace Gamma. To assess the transmissibility potential of Gamma and Delta VOCs, we studied the dynamics of RT-qPCR cycle threshold (Ct) score in the dominance period of each variant. The data suggest that Delta VOC has a higher transmission rate than Gamma VOC. We also compared relevant symptom patterns in individuals infected with both VOCs. The Delta-infected subjects were less likely to have low oxygen saturation or fatigue, altered results on chest computed tomography, and a propensity for altered X-rays. Altogether, we described the replacement of Gamma by Delta, Delta enhanced transmissibility, and differences in symptom presentation.

Suitable varieties and high-yielding population characteristics of late season rice in the northern margin area of double-cropping rice along the Yangtze River

<p id="C2">To clarify the suitable types of rice varieties and the mechanism of high yield formation, we mainly analyzed the yield difference between<italic> indica</italic> and <italic>japonica</italic> rice in late season in the northern margin of the double-cropping rice along the Yangtze River. The experiment was conducted from 2018 to 2019 in Lujiang, Anhui province. The differences of yield and yield components, dry matter accumulation, and growth period between <italic>indica</italic> and <italic>japonica</italic> rice were compared and analyzed through 17 <italic>indica</italic> rice and 17 <italic>japonica</italic> rice varieties (strains) which were cultivated in this local area. The results showed that the overall yield level of <italic>japonical</italic> rice was similar to that of <italic>indica</italic> rice. However, compared with <italic>indica</italic> rice, the<italic> japonica</italic> rice had the characteristics of fewer yield-limiting factors, superior safety of panicle fullness, higher yield stability, and ecological safety. High-yield <italic>japonica</italic> rice mainly increased the total dry matter accumulation from transplanting to heading stage so as to improve total spikelets and yield. The effects of dry matter accumulation at different stage with different panicle types on total spikelets were quite different. Among them, the dominance period of dry matter accumulation of medium-large panicle (102.3-112.0 grains per panicle) and small panicle <italic>japonica</italic> rice (52.0-99.7 grains per panicle) are transplanting to panicle differentiation and panicle differentiation to heading stage respectively and the correlation coefficients with total spikelets were 0.709 and 0.829, respectively. Further analysis revealed that dry matter accumulation during transplanting to panicle differentiation stage of large panicle <italic>japonica</italic> rice was significantly affected by the number of tillers at tillering stage, while the dry matter accumulation during panicle differentiation to heading stage of small panicle <italic>japonica</italic> rice was affected by the number of tillers and dry weight of single stem at heading stage. In summary, this study suggested that <italic>japonica</italic> rice was a suitable late season rice variety in the northern margin area of double-cropping rice along the Yangtze River. The number of spikelets in the high-yielding <italic>japonica</italic> rice was 33.8×10³-41.0×10³ m^-2, the dry matter accumulation at maturity was 15.2-16.6 t hm^-2, and the daily yield was 58.9-64.3 kg hm^-2 d^-1. Regarding the selection of varieties, high-yield large-panicle <italic>japonica</italic> rice, such as Jia 58, Wuyujing 6571, and Changyou 5, should have strong tillering ability; while small-panicle rice varieties, such as Ningjing 7, Wuyujing 5745 and Huxiangjing 151, should have a suitable number of tillers at heading stage and dry weight of single stem. In addition, it was necessary to study the optimized cultivation techniques for high-yielding <italic>japonica</italic> rice varieties with different panicle types in order to further develop the yield potential.

Severity of maternal infection and perinatal outcomes during periods of SARS-CoV-2 wildtype, alpha, and delta variant dominance in the UK: prospective cohort study

ObjectiveTo compare the severity of maternal infection and perinatal outcomes during periods in which wildtype, alpha variant, and delta variant of SARS-CoV-2 were dominant in the UK.DesignProspective cohort study.Setting194 obstetric...

Gam-COVID-Vac, EpiVacCorona, and CoviVac effectiveness against lung injury during Delta and Omicron variant surges in St. Petersburg, Russia: a test-negative case–control study

BackgroundMonitoring vaccine effectiveness (VE) remains a priority for epidemiological research throughout the COVID-19 pandemic. VE against infection declines with the emergence of new SARS-CoV-2 variants of concern (VOC), but VE against the severe disease remains high. Therefore, we aimed to estimate the effectiveness of COVID-19 vaccines used in Russia against lung injury during Delta and Omicron VOC surges.MethodsWe designed a case–control study (test-negative design) to estimate VE against any (any volume of involved lung parenchyma) and severe (>50% of involved parenchyma) lung injury detected on computer tomography and associated with COVID-19 between October 1, 2021–April 28, 2022 (Delta VOC dominance period followed by Omicron dominance period). We included the data of patients with symptomatic confirmed SARS-CoV-2 infection referred to the low-dose computer tomography triage centres.ResultsAmong 23996 patients in the primary analysis, 13372 (55.7%) had any lung injury, and 338 (1.4%) had severe lung injury. The adjusted for age, sex and triage centre VE estimates against any lung injury were 56% (95% confidence interval 54–59) for two-dose Gam-COVID-Vac (Sputnik V), 71% (68–74) for three-dose Gam-COVID-Vac (booster), 2% (−27 to 24) for EpiVacCorona, and 46% (37–53) for CoviVac. VE estimates against severe lung injury were 76% (67–82) for two-dose Gam-COVID-Vac (Sputnik V), 87% (76–93) for three-dose Gam-COVID-Vac, 36% (−63 to 75) for EpiVacCorona, and 80% (45–92) for CoviVac.ConclusionsGam-COVID-Vac remained effective against lung injury associated with COVID-19 during Delta and Omicron VOC surges, and one Gam-COVID-Vac booster could be seen as an appropriate option after a two-dose regimen. CoviVac was also effective against lung injury. EpiVacCorona use in population-based vaccination should be halted until effectiveness and efficacy evidence is provided.Trial registration The joint study of COVID-19 vaccine effectiveness in St. Petersburg was registered at ClinicalTrials.gov (NCT04981405, date of registration—August 4, 2021).

Наступление нарциссической культуры: последствия для образования, науки и политики

Scientists and teachers have been discussing the peculiarities of dissemination of postmodernism in different areas of society, usually ignoring universities and scientific organizations. During the dominance period of the rationally-oriented intellectual culture, the communication methods among specialists have been developed, assisting to describe any phenomena. Postmodernism, factually revolutionizing communication and discourses, radically changes the communities producing them. Without understanding the essence of these changes, it becomes almost impossible to comprehend what, how and why they are engaged in universities and scientific organizations, and what is happening in economy and in politics? The mentioned transformations have been identified in the article as a phenomenon of the onset of narcissistic culture. Accepting the concept of high culture and a multitude of local cultures, it is reasonable to note the increasing processes of the cultural patterns, which transfer between different areas of private and public life, which more and more complicate being of an individual in culture, when, in particular, the expansion of human freedom is accompanied by enhancing the control over him. Imagine a carnival unfolding in a space arranged like a rhizome (fractal). In this way, from the deconstruction of concepts we move on to the deconstruction of slogans, which, presumably, served as a source for a new type of public perturbation from the end of the 80s of the 20th century till the present time. In modern universities, research institutes, entrepreneurship, politics along with liberal values a large-scale dissemination of narcissistic culture took place. The slogan Science Must Serve the People is being deconstructed. Thus, narcissistic culture unfolds beyond the boundaries of this slogan. At the same time, the carriers of narcissistic culture belonging to different generations, educational and academic statuses become not only carriers of new patterns of behavior, but pose themselves in a very special way in society. Individualization beats the standards, including professional ones. Recognizing that culture is an external factor to subjects, mainly predetermining collective memory, as well as collective thinking and imagination (expectations), and the transition from mass to narcissistic culture changes the social roles and transforms the society. Even in elite universities professionalism is squeezed out in order to achieve the needs for convenience and comfort. The loss of the importance of professionalism in the environment causes a response - self-isolation (absenteeism) of specialists. In the field of entrepreneurship, replacing mass culture with a narcissistic one required new artistic models, a change in behavior style, and legitimization of hedonism and egocentrism. Perhaps this is the reason for the decline in the world economic growth rates. Under the prevailing conditions a healthy lifestyle becomes a necessary setting for meeting certain social and political indicators. There has been a dramatic cultural shift in electoral democracy. It is no longer important to ‘enrapture the hearts and souls’, but to be in admiration of yourself and your close environment. Absenteeism is an immanent feature of narcissistic culture, leading the individual to alienation from the political life of the society. Narcissistic culture has always existed, but postmodernism served as a unique medium for its dissemination. Despite numerous criticisms of narcissistic culture, it brings a high diversity to all areas where it penetrates, and this diversity can act as a trigger mechanism to the beginning of a new round for the development of mankind. Narcissistic culture in the 20th century is an external factor changing the flow of all social processes, including economic, political, and social ones. A project ignoring the peculiarities of cultural narcissism discussed above is doomed to failure.

Kinetic dominance and psi series in the Hamilton-Jacobi formulation of inflaton models

Single-field inflaton models in the kinetic dominance period admit formal solutions given by generalized asymptotic expansions called psi series. We present a method for computing psi series for the Hubble parameter as a function of the inflaton field in the Hamilton-Jacobi formulation of inflaton models. Similar psi series for the scale factor, the conformal time and the Hubble radius are also derived. They are applied to determine the value of the inflaton field when the inflation period starts and to estimate the contribution of the kinetic dominance period to calculate the duration of inflation. These psi series are also used to obtain explicit two-term truncated psi series near the singularity for the potentials of the Mukhanov-Sasaki equation for curvature and tensor perturbations. The method is illustrated with wide families of inflaton models determined by potential functions combining polynomial and exponential functions as well as with generalized Starobinsky models.

Level of circulating concentrations of progesterone during ovulatory follicle development affects timing of pregnancy loss in lactating dairy cows

The objective of this experiment was to determine the effect of high versus low progesterone (P4) during the pre-dominance or dominance phase (or both) of ovulatory follicle development on follicular dynamics and fertility of lactating dairy cows. Progesterone (P4) was manipulated to reach high (H) or low (L) serum concentrations during the pre-dominance phase (d 0 to 4 of the wave) and dominance phase (d 5 to 7 of the wave) of a second follicular wave ovulatory follicle, creating 4 treatments: H/H, H/L, L/H, and L/L. Luteolysis was induced with PGF2α on d 7 of the wave and ovulation was induced with GnRH 56 h after PGF2α. Cows (n = 558) received artificial insemination (AI) 16 h following GnRH. Pregnancy was determined at 6 intervals during gestation and at calving to quantify pregnancy loss beginning at d 23 post-AI utilizing pregnancy-specific protein B (PSPB) in novel within-cow comparisons. Cows with single ovulations assigned to the L/L treatment had greater pre-ovulatory follicle diameter compared with cows assigned to the L/H or H/L treatments. Cows with single ovulations had greater pre-ovulatory follicle diameter compared with cows with double ovulations. Low P4 in H/L, L/H, and L/L increased double ovulation rate compared with H/H. Cows with double ovulations had greater pregnancies per AI (P/AI) on d 23 post-AI compared with cows with single ovulations but had greater losses if ovulations were unilateral. Cows with low P4 during the entire period of the ovulatory follicle development also had greater P/AI on d 23 post-AI compared with cows with high P4 during both phases. However, full-term P/AI was not different between treatments. This was a result of the greater incidence of pregnancy losses between d 35 and 56 of gestation for cows with unilateral double ovulations compared with bilateral double ovulations and single ovulatory cows. Cows with single ovulation and low circulating P4 during the dominance period of follicle development had increased pregnancy losses between d 35 and 56 of gestation compared with cows with single ovulations and high P4. The PSPB measurements on d 16 and 23 post-AI were highly accurate in the prediction of pregnancy at d 28. The PSPB differed on d 23 and 28 between cows that had versus cows that did not have pregnancy losses between d 28 and 35 of gestation. In summary, circulating concentrations of P4 during ovulatory follicle development affected numbers of follicles ovulated and timing of subsequent pregnancy losses.

Europeanization of Ghanaian Names and Their Representations in Drama

In Ghanaian culture a name could tell the story of when a person is born, how the person is born or some special event at the time of their birth. However, difficulties in pronunciation, as well as misinterpretation of local names by the then colonial masters resulted in alterations of many local names to the convenience of the British and Portuguese, resulting in evolution of some local names over the years to new pronunciations and spellings. During colonial dominance and immediate post-colonial period, some renowned Ghanaian playwrights used names that reflect this confusion and consequently imbedded in their characters, traits that depicted such misrepresentations as well as the specific roles the playwright assigned them. This paper reflects on the character names in relation to the settings in selected Ghanaian plays and how these characters reveal Ghanaian naming philosophies in the ways these characters play their roles. The focus is on, but not limited to, playwrights such as Kobina Sekyi, Ama Ata Aidoo, J.C. deGraft and F.K. Fiawoo who seem to be enduring points of reference particularly when one appreciates the reasoning that informs how they craft their characters, courtesy the curiously noteworthy names they drape them in. The discussion is preceded by deliberations on the indigenous naming, names and their significance furthering on the colonial influence and attempts to Europeanize.

The role of urban form in sustainability of community: The case of Amsterdam

Urban policy has increasingly emphasized the compact city and higher density urban forms in reaching sustainability goals. Although environmental and economic advantages of densification have been empirically supported, the relation between higher density environments and social sustainability has been more contentious. Concerns have been raised regarding the social outcomes of high-density urban contexts; however, these connections have neither been well explored nor understood. Using the city of Amsterdam, considered a case of high-quality compact city form, our study looks at how specific neighbourhood built form relates to key measures of sustainability of community. Despite previous concerns regarding the effects of density, the study reveals that higher densities have no significant impact on local social capital, sense of community or resident satisfaction. Rather, other built-form measures such as scale, existence of local stores, degree of automobile dominance and construction period were of greater importance. The study of high-quality urban environments in Amsterdam challenges notions that higher densities are detrimental to social and community experience and proposes that the specific urban form of higher density neighbourhoods is of greater importance than absolute density.

Touch Interacts with Vision during Binocular Rivalry with a Tight Orientation Tuning

Multisensory integration is a common feature of the mammalian brain that allows it to deal more efficiently with the ambiguity of sensory input by combining complementary signals from several sensory sources. Growing evidence suggests that multisensory interactions can occur as early as primary sensory cortices. Here we present incompatible visual signals (orthogonal gratings) to each eye to create visual competition between monocular inputs in primary visual cortex where binocular combination would normally take place. The incompatibility prevents binocular fusion and triggers an ambiguous perceptual response in which the two images are perceived one at a time in an irregular alternation. One key function of multisensory integration is to minimize perceptual ambiguity by exploiting cross-sensory congruence. We show that a haptic signal matching one of the visual alternatives helps disambiguate visual perception during binocular rivalry by both prolonging the dominance period of the congruent visual stimulus and by shortening its suppression period. Importantly, this interaction is strictly tuned for orientation, with a mismatch as small as 7.5° between visual and haptic orientations sufficient to annul the interaction. These results indicate important conclusions: first, that vision and touch interact at early levels of visual processing where interocular conflicts are first detected and orientation tunings are narrow, and second, that haptic input can influence visual signals outside of visual awareness, bringing a stimulus made invisible by binocular rivalry suppression back to awareness sooner than would occur without congruent haptic input.