Periodic longitudinal forces in structural elements caused by operational or seismic influences, at certain values of the parameters of these forces can cause the occurrence and growing of transverse oscillations of these elements. This phenomenon is called parametric resonance or loss of dynamic stability. In the works of N. M. Belyaev, N. M. Krylov, М. М. Bogolyubov, E. Mettler, V. N. Chelomey, V. V. Bolotin flat problems of dynamic stability of frame structures were investigated. In this paper the modified Bolotin’s method, proposed to solve flat problems of dynamic stability of frames, is used. Instead of the deformation method used by V. V. Bolotin to construct analytical expressions of deflections of frame rods, in the modified method the numerical-analytical method of boundary elements is used. The article proposes a method for constructing domains of dynamic instability of frames in the space of parameters (frequency and amplitude) of seismic and operational dynamic influences that cause longitudinal forces in the rods, which periodically change over time and lead to unlimited growth of transverse oscillations amplitudes in the domains of instability. The proposed method is demonstrated in example, which considers the spatial problem of dynamic stability of a П-shaped frame with two concentrated masses located on it, which are under the action of vertical periodic forces. These forces create periodic longitudinal forces in the vertical rods of the frame. Areas of dynamic instability of the frame were constructed. Taking into account the destructive effect of oscillations is important for practical application. The most dangerous destructive effect of oscillations is observed in earthquakes and explosions. The study of this action makes it possible to avoid undesirable consequences of oscillations by limiting their level and to solve important practical problems of the dynamics of structures. Solving dynamics problems is a difficult problem. Dynamic calculation of structures provides their bearing capacity under the combined action of static and dynamic loads.