Functional Division Research Articles

ОГЛЯД СУЧАСНИХ ПІДХОДІВ ДО УПРАВЛІННЯ МАТЕРІАЛЬНИМИ РЕСУРСАМИ ПРОМИСЛОВОГО ПІДПРИЄМСТВА

The purpose of the article is a general overview of approaches to the management of material resources of a manufacturing enterprise. Approaches to defining the concepts of "material resources" and "material resources of the enterprise" and the composition of the material resources of the enterprise are analyzed. It is agreed that material resources include raw materials, main and auxiliary materials, component products, fuel, work in progress and production waste. Features of material resources as an object of management at the enterprise are highlighted and include material form, usage in production process, transfer of their value to the value of produced products. An analysis of individual approaches to material resource management is carried out, in particular, integral, functional, logistic and reengineering approaches. An improved list of material resource management tasks within the framework of individual functional divisions of the enterprise is proposed. The functional divisions include economic and planning, marketing, procurement, accounting, legal department, production, information department. Areas of activity in the field of management of material resources of an industrial enterprise within the framework of separate management functions are suggested and grouped, including activities aimed at coordinating other management functions. In particular, the market factor is the basis of planning, and the need to implement an information system for the management of material resources and ensure its smooth operation to ensure the coordination of management activities for the management of material resources is emphasized. The place and role of the company's information system is determined as such that helps unification of data sources, serves as information base for management decisions, allows to improve the process of management of material resources, ensures higher level of control and risks prevention, reduces the risk of human factor. Proposals for further scientific research were formed.

ВИКОРИСТАННЯ ЕЛЕКТРОННИХ СИСТЕМ ДОКУМЕНТООБІГУ ТА ЗВІТНОСТІ ЛОГІСТИЧНИМИ КОМПАНІЯМИ УКРАЇНИ

The article explores the possibilities and ways of using information technologies for document management and electronic reporting at logistics enterprises. Theoretical approaches to understanding the goals and tasks of logistics information systems in transport technologies have been considered. The main information technology systems that change the logistics industry in modern conditions have been characterized, namely: RPA; chat bots; visualization; Artificial Intelligence; predictive analytics. The electronic technologies used for information provision in Ukrainian practice, the IT-Enterprise ERP system of JSC ‘Ukrposhta’ and the CRM system of the company ‘Epicentr K’ have been analyzed. Their characteristics and advantages of use have been defined. It have been found that the basis of the functional component of the modern information system is a single module of operations between the links of the logistics system, which determines the relationship between the functional divisions of the company (in terms of the implementation of logistics functions), intermediate links and consumers of the company’s products. The implementation of a logistics information system in the work of a logistics enterprise makes it possible: - to increase the efficiency of its work, achieve a high level of service for customers and ensure effective control; - to ensure a modern approach to the management of implementation processes and the organization of various types of events; - to monitor the efficiency of commercial operations; - to conduct an analysis of the profitability of the activity; - to increase the effectiveness of price policy, etc. The problems of the introduction of electronic document flow and reporting systems in Ukraine have been noted: - the problem of interoperability in electronic document flow; - lack of clear standards and requirements for electronic reporting, companies may hesitate to switch to this type of reporting; – constant changes in legislation and requirements can create difficulties for enterprises in implementing stable electronic reporting systems; - inconsistency of electronic reporting formats with global ones; high implementation costs; - concerns about data privacy and security can deter companies from switching to electronic reporting, especially when the security of information on the network is at stake.

7097 The role of mitochondrial fraction locating cytoplasmic and peridroplet area in white adipocyte

Abstract Disclosure: I. Mori: None. T. Ishizuka: None. H. Morita: None. K. Kajita: None. White adipocytes (WAs) are involved in the formation of obesity and insulin resistance, but little is known about the role of WAs mitochondria. A recent study revealed that the mitochondria of brown adipocytes (BAs) consist of cytoplasmic mitochondria CM), which is responsible for β-oxidation, and peridroplet mitochondria (PDM), which supplies triglyceride to lipid droplets. However, it is unclear whether such a functional division exist in WA mitochondria. In this study, we examined whether the pellets obtained from cytoplasmic and oil layers of WAs of C57/BL/J mice by centrifugation were mitochondria. Since mitochondrial DNA, mitochondrial protein, Mitotracker Red staining, and mitochondrial images in electron microscope were detected in both fractions, they were considered to be cytoplasmic mitochondria (CMw) and peridroplet mitochondria (PDMw) in WAs, respectively. The amount of CMw and PDMw were greater in epididymal fat than in inguinal fat. CMw had higher β-oxidation activity than PDMw. PDMw was associated with perilipin 1/3 and diacylglycerol acyltransferase 2. The amount of PDMw was elevated in epididymal fat of mice fed a high-fat diet (HFD) for 2 and 4 weeks compared to normal chew-fed mice. These results suggested that CMw was involved in β-oxidation, and PDMw in droplet expansion. Although numerous researches have been shown that amount of mitochondria is suppressed in obese WAs, our results revealed that PDMw might be involved in the early stage of obesity formation. Presentation: 6/1/2024

Secure base and mental health in children: a narrative review.

Childhood is a crucial period for the formation of an individual's attachment type. Previous studies focused more on how to directly intervene in children's mental health problems such as depression, and less on how to improve children's mental health from the perspective of attachment relationship. Secure base, as one of the core concepts of attachment theory, plays an important role in the whole process of children's psychological development. In this article, we review the concept of the secure base, describe current clinical practice and suggest future directions. A literature search was performed within electronic databases such as Web of Science, PubMed, and CNKI. Chinese and English articles focusing on the secure base and attachment relationship among children were retrieved. Their publication dates were set from the inception of the database to August 6, 2024. While the secure base significantly impacts early childhood, a safe base may also be established through group and teacher-student relationships to activate individual secure attachment schemas. Most prior studies concentrated on the mother-child bond, with limited exploration of the father's role in the family dynamic. Furthermore, children's secure attachment development is not only influenced by parents' secure base script knowledge (SBSK) but also by intergenerational transmission. The underlying structure of secure base scripting knowledge plays a distinct role in middle childhood mental health. The mechanism by which family structure, the functional division of family roles, and the potential structure of safe-base script knowledge influence children's secure attachment development at various stages warrants further elucidation, including investigating cross-gender and cross-cultural stability. To facilitate the development of children's secure attachment pathways, it is essential to consider different attachment styles within parents and diverse family structures (including those in lesbian, gay, bisexual). From a clinical psychotherapy perspective, this review offered novel insights and practical guidance on how the secure base mechanism impacts children's mental health, with the overarching goal of mitigating the risk of mental health problems.

The Primacy Evaluation and Pattern Evolution Mechanism of the Central City in Nanjing Metropolitan Area

Economic globalisation has accelerated the cross-regional flow of resource elements and broken through the constraints of traditional regional administrative boundaries. Urban agglomerations are core carriers that drive and accelerate regional integration development and can promote the division of urban functions and cooperation. This study considers the Nanjing metropolitan area as a case study to construct a comprehensive first-degree evaluation index system for cities from a factor-flow perspective, focusing on economic, cultural, and transportation connections. We found that (1) Nanjing, which has long been ranked first, shows a downward trending score, dropping from 0.956 in 2017 to 0.937 in 2023; (2) The comprehensive first-degree spatial structure of metropolitan-area cities presents a network hierarchical development feature of “one core, multiple centres, and multiple areas”. With Nanjing as the regional core city, Chuzhou (0.879), Yangzhou (0.915), and Wuhu (0.897) as sub-centre cities, and other cities as sub-regional nodes, the urban system structure gradually forms; (3) The indicators of economic (0.166 **), cultural (0.226 **), and transportation (0.644 ***) element connections were interrelated and mutually reinforced, forming a unified entity with internal connections. This study quantitatively measured the level of integrated development in the Nanjing metropolitan area and provided a reference for formulating regional policies.

Urban functional area building carbon emission reduction driven by three-dimensional compact urban forms’ optimization

Previous optimization approaches with regard to the overall urban form can no longer meet the demand for accurately implementing building energy consumption carbon emission reduction at small spatial scales. This study constructed building energy consumption-oriented urban functional area division method using points of point-of-interest (POI), three-dimensional building and roadway data with urban functional areas as units. The method linked POI to buildings, using building volume as an auxiliary parameter to determine the functional attributes of blocks while taking into account the building operational energy consumption. The residential functional areas, commercial functional areas and industrial functional areas, which account for more than 90% of the total building operation energy consumption and the top three in terms of share, are selected as the analysis objects. Geographic detector was applied to analyze the mechanism of carbon metabolism in the compact spatial patterns of these three functional areas. The case study in Xiamen, China reveals that (1) Three-dimensional building compactness is an important factor influencing building energy consumption(normalized difference vegetation index q-value is 0.227); (2) the difference in energy consumption between different compactness classes in residential and commercial functional areas is significant, while not in industrial functional areas; (3) according to the three-dimensional building compactness optimization path of this study, the building operation energy consumption in central Xiamen City could be optimized to reduce by 7% in 2015. Based on the self-created building energy consumption-oriented functional area division method, it is concluded at the functional areas scale that different types of urban functional zones have different optimization methods for three-dimensional building compactness. Such optimization can save construction resources and achieve double carbon more effectively.

Political and Legal Disarrays of Separation of Powers in the Oromia Regional State Structure

In principle, a functional division of powers is a prerequisite for limited government. Oromia Regional State, the largest sub-national state in the Ethiopian federation, can exercise upward influence if it develops a limited government with a strong separation of power within its borders. The purpose of this paper is to make an effort to look into the political and legal difficulties that threatened separation of power among the major participants in the region's power dispersion structure. In order to achieve this, the study employed interviews with a few specifically chosen experts and officials from the three arms of regional government, as well as a pertinent literature analysis and personal observation. This led to the discovery that several political and legal constraints significantly restrict the power structure in the region. Ultimately, it was proposed that in order for the region to ensure genuine separation of powers, political players would need to work together to create a political culture that supports constitutionalism and maintain their commitment to the rule of law.

Exploring affordable housing policy in federal states: social housing and housing allowances in Australia, Austria, Canada, and Germany

ABSTRACT In federal states, constituent units play an important role in affordable housing policy. Nevertheless, insights into affordable housing policy in federations are lacking. To lay the grounds for future research about an increasingly salient policy field, this research note explores the degree of de/centralization in affordable housing policy in Australia, Austria, Canada, and Germany, focusing on the two main policy instruments: social housing and the housing allowance. The research note develops an analytical framework that allows the examination of the relative significance of the federal government and the constituent units, and it applies this framework to the four countries. The research note highlights that legislative authority often does not fully capture the degree of de/centralization. Governments’ decision to provide a policy instrument, the relative importance of policy instruments, the provision of conditional grants, and the existence of a functional division of powers must also be considered.

Hand-Jaw Coordination as Mice Handle Food Is Organized around Intrinsic Structure-Function Relationships.

Rodent jaws evolved structurally to support dual functionality, for either biting or chewing food. Rodent hands also function dually during food handling, for actively manipulating or statically holding food. How are these oral and manual functions coordinated? We combined electrophysiological recording of muscle activity and kilohertz kinematic tracking to analyze masseter and hand actions as mice of both sexes handled food. Masseter activity was organized into two modes synchronized to hand movement modes. In holding/chewing mode, mastication occurred as rhythmic (∼5 Hz) masseter activity while the hands held food below the mouth. In oromanual/ingestion mode, bites occurred as lower-amplitude aperiodic masseter events that were precisely timed to follow regrips (by ∼200 ms). Thus, jaw and hand movements are flexibly coordinated during food handling: uncoupled in holding/chewing mode and tightly coordinated in oromanual/ingestion mode as regrip-bite sequences. Key features of this coordination were captured in a simple model of hierarchically orchestrated mode-switching and intramode action sequencing. We serendipitously detected an additional masseter-related action, tooth sharpening, identified as bouts of higher-frequency (∼13 Hz) rhythmic masseter activity, which was accompanied by eye displacement, including rhythmic proptosis, attributable to masseter contractions. Collectively, the findings demonstrate how a natural, complex, and goal-oriented activity is organized as an assemblage of distinct modes and complex actions, adapted for the divisions of function arising from anatomical structure. These results reveal intricate, high-speed coordination of disparate effectors and show how natural forms of dexterity can serve as a model for understanding the behavioral neurobiology of multi-body-part coordination.

Morphological and Functional Polycentric Urbanization in Colombo Metropolitan of Sri Lanka Using Time-Series Satellite Images from 1988–2022

Examining urban growth in metropolitan areas from both morphological and functional perspectives is paramount for sustainable development in developing and developed countries. As a collaborative and critical approach, polycentrism operates concurrently at local, regional, and national levels. However, the decentralized morphologies and functional attributes of polycentric urban spaces are yet to be adequately explored, despite their significant influence on sustainable urban planning and management. Colombo, the only metropolitan area in Sri Lanka, has experienced considerable yet ambiguously imbalanced spatial growth due to insufficient data. This study employed time-series satellite imagery from 1988 to 2022, in conjunction with a network model, to elucidate Colombo’s uneven urban patterns, while achieving an accuracy of over 80% throughout the period. The results revealed that the metropolis has evolved into a polynuclear city, complicating the identification of centers and their corresponding developmental stages. Nevertheless, the study successfully pinpointed the morphological and functional Grama Niladhari divisions, disclosing the morphological features of centralized dispersion and the functional traits of decentralized concentration. These insights provide significant implications for local government, guiding urban planning initiatives to achieve sustainable development goals.

Exploring the temporal-spatial characteristics and determinants of high-quality development of city clusters in China

The complexity, severity, and uncertainty of the international situation have prompted the development of city clusters to focus more on resilience and the building of infrastructures and safeguards. Chinese-style modernization proposes a new realization path for the high-quality development (HQD) of city clusters, based on which an evaluation system for HQD indicators of city clusters is constructed. We also measured the HQD levels of 19 city clusters from 2011 to 2021 and analyzed their spatial differentiation characteristics, agglomeration evolution characteristics, and influencing factors by using kernel density, standard deviation ellipse, Moran's index, geographic detector, and geographically weighted regression. The study revealed that (1) the overall level of HQD of China's city clusters shows a trend of continuous growth, and there is obvious polarization in the high quality of city clusters in different regions. (2) The spatial distribution of HQD in city clusters decreased in the "East, Center and West" direction, but the spatial patterns of "Southeast highlighting" and "Northwest rising" became more obvious. (3) The HQD of city clusters shows obvious spatial agglomeration characteristics and overall presents a spatial pattern of "hot in the east and cold in the west", with the scope of the cold spot area gradually shrinking, and the hot spot area tends to spread outward, with mature city clusters at the core. (4) The influencing factors of HQD in Chinese city clusters are diverse, with financial levels, digital economics, human capital and green innovations having decreasing influence on HQD in city clusters but showing an obvious two-factor enhancement trend, with financial levels being able to effectively stimulate the driving potential of other factors. Financial levels can effectively stimulate the driving potential of other factors. (5) The coefficients of the driving factors affecting the HQD of city clusters vary significantly spatially, with human capital, financial levels and green innovations showing a north‒south hierarchical banded distribution of "high in the south and low in the north", and digital economy shows an east-west hierarchical belt distribution of "high west and low east". Based on the above conclusions, the realization path of accelerating the HQD of China's city clusters is proposed by optimizing the functional division of labor of the city clusters, giving full play to the comparative advantages of the hinterland city clusters, and relying on the high level of the city clusters for opening up.

Legal regulation of the powers of the Antimonopoly Committee of Ukraine to exercise control in the field of banking activity

Control is explained as a systematic verification of the implementation of laws, directives, resolutions and decrees or as state or public measures for the supervision, inspection, accounting of the activities, behavior of natural and legal persons, i.e. control is an inspection in order to ensure the reliability and legality of the actions specified and the process of tracking the actual implementation of plans. Unfortunately, the legal reference literature and the current legislation of Ukraine do not contain a unified approach to the definition of the legal content of the term «control». The Encyclopedia of Law, for example, defines «control» (French controle – check, from Old French contre-role – a list with a duplicate for verification) – as verification of the implementation of laws, decisions, etc. The article examines the place of the Antimonopoly Committee of Ukraine in the system of bodies exercising control in the sphere of banking activity. It is determined that state control is one of the main functions (forms, methods) of public administration. The degree of efficiency of state control, despite the sphere of its implementation, is mainly determined by the quality of legal support of control activities, a certain level of socio-economic and logistical support of state control bodies, the level of mobility and balance of the system of control bodies. It is the balanced construction of the system of state control bodies that is an important prerequisite for the successful functioning of the entire system of state bodies. Analyzing the variety of laws and by-laws, as well as scientific literature on the issue of subjects of control in the sphere of banking activity, it is determined that control over the activities of banking institutions is a complex system, which has two main directions: external control and internal control. Subjects of banking control can be represented both externally (by state and independent regulatory authorities) and internally. The subjects of banking control by the state include: the Accounting Chamber of Ukraine, Control Departments under the Administration of the President of Ukraine, the State Financial Inspection of Ukraine, the Ministry of Economic Development and Trade of Ukraine, the National Bank of Ukraine, the State Fiscal Service of Ukraine, the State Treasury Service of Ukraine, the State Property Fund of Ukraine, state extra-budgetary funds (such as the Pension Fund of Ukraine), the National Securities and Stock Market Commission, law enforcement agencies and others in accordance with the current legislation. Independent audit firms act as subjects of independent control, and the subjects of internal control are the Supervisory Board, the Audit Commission, the Management Board (Board of Directors), functional divisions of the bank, and its internal audit service. The article thoroughly covers the functions of the Antimonopoly Committee of Ukraine of control in the sphere of banking activity, its important role and importance. The article defines the main functions assigned to the Antimonopoly Committee of Ukraine by the current legislation of Ukraine. On the basis of the study, it is established that in case of violation of the current legislation, material and operational-economic liability is provided for business entities in general, and banks in particular. When writing the article, on the basis of the studied material, it is established that the common type of operational and economic sanctions applied by the authorities are: cancellation of licenses and termination of foreign economic operations. And in case of abuse of monopoly position in the market, the Antimonopoly Committee of Ukraine has the right to adopt a resolution on the forced division of monopoly formations.

DecorPGNet: Functional Area Division and Layout Algorithm Model in Living Rooms of Chinese Apartment-Style Family Homes

DecorPGNet: Functional Area Division and Layout Algorithm Model in Living Rooms of Chinese Apartment-Style Family Homes

The VeSFADS structural classification of vestibular disorders

The issuing of International Classification of Vestibular Disorders（ICVD） by Brny society（2015） greatly facilitates the progress of vestibular medicine. The syndromic classification of vestibular disorders by ICVD enable the physician to narrow the spectrum of differential diagnosis for the vestibular disorder in clinical practice. However, the division of vestibular pathway, especially the central vestibular system, has not be classified yet in the ICVD（2015）. Central vertigo, being a group of heterogeneous disorders, may present diverse clinical spectrums. The misdiagnosis of central vestibular as well as peripheral vestibular disorders have been reported in the clinic practice. Therefore, the author by review study proposes a structural classification of vestibular disorders combined the Vestibular System Functional Anatomy Division with Syndromes（VeSFADS）. The VeSFADS classification of vestibular disorders could help the physician in clinical practice to narrow the spectrum of vestibular disorders, in addition to the syndromic classification, by the clinical feature of vestibular disorders from different division of vestibular system. And the VeSFADS classification of vestibular disorders may facilitate to clarify the clinical features of vestibular disorders at different Division of vestibular pathway.

Revealing miRNAs patterns by employing matrix representations and energy analysis

MicroRNAs (miRNAs) are small, non-coding RNA molecules that regulate gene expression. Despite their relatively short length (about 21 nucleotides), they can regulate thousands of transcripts within a cell. Due to their low complementarity to targets, studying their activity and binding region preferences (3′UTR, 5′UTR, or CDS) is challenging. In this paper, we analyzed a set of human miRNAs to uncover their general patterns. We began with a sequence logo to verify conservation at specific positions. To discover long-range correlations, we employed chaos game representation (CGR) and genomatrix, methods that enable both graphical and analytical analysis of sequence sets and are well-established in bioinformatics. Our results showed that miRNAs exhibit strongly non-random and characteristic patterns. To incorporate physicochemical properties into the analysis, we applied the electron-ion interaction potential (EIIP) parameter. An important part of our study was to validate the division of miRNAs into two parts—seed and puzzle. The seed region is responsible for target binding, while the puzzle region likely interacts with the RISC complex. We estimated duplex binding energy within the 3′UTR, 5′UTR, and CDS regions using the miRanda tool. Based on the median energy distribution, we divided the miRNAs into two subsets, reflecting different patterns in chaos game representation. Interestingly, one subset displayed significant similarity to conserved and highly confidential miRNAs. Our results confirm the low complementarity of miRNA/mRNA interactions and support the functional division of miRNA structure. Additionally, we present findings related to the localization of transcript target sites, which form the basis for further analyses.

Collaborative Governance on Energy Management Online Reporting According To Energy Conservation Policy

<p>Energy savings in Indonesia are still far from the expected target of only around 79,358 GWh/141,220 GWh. The achievement is based on online reporting of energy management by industry according to government regulation No. 70 of 2009 which is reported regularly every year. This is done by the government as support in reducing the impact of climate change that occurs today. The qualitative method used in this study was a collaborative governance process approach between the government and industry with a collaborative governance cycle that occurs, is then analyzed, and conclusions drawn. The research results obtained include difficulties in identifying industries because there are still differences in authority within different government agencies. There are still 30% of industries that meet the requirements but have not done online energy management reporting including the fulfillment of all energy management activities that must be carried out. Articles related to incentives and disincentives that have not been fully implemented by the government. Collaborative governance is very important to be applied in the division of tasks, functions, and roles of each party involved. So that all can run according to their rights and responsibilities so that the achievement of future energy saving targets can be achieved. </p>

Zinc Levels and Affecting Factors in Children and Adolescents in a Children’s Hospital

Objective: This study aims to determine the zinc levels and the factors affecting zinc levels in children and adolescents aged 10-18. Zinc is an essential trace element that plays a critical role in various biological processes, including immune function, protein synthesis, and cell division. Adequate zinc levels are particularly important during periods of rapid growth, such as adolescence, as deficiencies can lead to impaired growth, increased susceptibility to infections, and delayed sexual maturation. Understanding the factors that influence zinc levels in this age group is crucial for developing effective nutritional and health interventions. Methods: This is a retrospective, descriptive, correlational, and cross-sectional study conducted with 542 children and adolescents between the ages of 10-18 to determine zinc levels. Descriptive statistics were analyzed as numbers, percentages, and mean values. Chi-square test and linear regression analysis were used in the analysis of the data. The differences were considered to be statistically significant at p < 0.05. Results: The average age of the patients is 13.64±2.63. Of the children participating in the study, 60.1% (n=326) are female and 39.9% (n=216) are male. It was determined that 12.7% (n=69) of the children had low zinc levels. There was no significant difference found between the zinc values of children according to gender (p>0.05). Although the percentage of children with low zinc levels increased as their age increased, this increase was not statistically significant (p> 0.05). Zinc level was significantly predicted by the combination of the eight variables (p<0.001). The eight variables included in the model were found to explain 5.6% of the variance in zinc level. Conclusions: It was found that zinc levels were significantly affected by LDL Cholesterol and iron. Although other variables were not significant on their own, they were found to have an impact on zinc levels when combined with LDL Cholesterol and iron. The interaction between LDL cholesterol, iron, and other variables creates a complex network affecting zinc levels in the body. We believe that monitoring and managing LDL cholesterol, iron, and zinc levels during adolescence will be beneficial in the prevention and treatment strategies of diseases such as cardiovascular diseases, diabetes, and chronic inflammatory conditions. We also believe that it will contribute to the development of health policies and help reduce healthcare costs.

Card fault diagnosis of the pressurized water reactor off-heap nuclear measurement system based on expert experience and convolutional neural network

The reactor nuclear measurement system is important in a nuclear power plant. Its main role is to measure the reactor's core power distribution using detectors and calibrate and provide data on the core fuel consumption. This study describes the lack of fault data and the lack of diagnostic methodology research in the overhauling process and fault diagnosis of the off-heap nuclear measurement system core card. This core card provides the detectors with the necessary working conditions. It also collects signals. In this study, we propose a methodology for the fault diagnosis of the card through circuit analysis, simulation of functional module division, fault data generation, and training of a convolutional neural network diagnostic model. The proposed methodology can transform the drawings into convenient diagnostic processes and algorithms based on expert experience. These drawings are difficult to use in actual overhauling conditions. The corresponding experimental equipment was designed for practical testing. The experimental results show that the accuracy of the obtained diagnostic model for classifying preset faults can reach 99.5%, indicating that this model can be applied in actual working conditions. The accuracy of the trained diagnostic model in classifying 13 kinds of faults in the training set during the actual test was tested. Results show that the accuracy rate is close to 100%. Moreover, the correction of the model using the real maintenance data in applying the actual maintenance conditions was also analyzed. The intelligent diagnostic system that centers on the fault diagnosis method investigated in this study has been applied in the pressurized water reactor off-heap nuclear measurement system digital transformation and upgrading project of Qinshan No. 2 Plant.

Medial Amygdalar Tau Is Associated With Mood Symptoms in Preclinical Alzheimer’s Disease

BackgroundWhile the amygdala receives early tau deposition in Alzheimer’s disease (AD) and is involved in social and emotional processing, the relationship between amygdalar tau and early neuropsychiatric symptoms in AD is unknown. We sought to determine whether focal tau binding in the amygdala and abnormal amygdalar connectivity were detectable in a preclinical AD cohort and identify relationships between these and self-reported mood symptoms. MethodsWe examined 598 individuals (347 amyloid positive [58% female], 251 amyloid negative [62% female] subset in tau positron emission tomography and functional magnetic resonance imaging cohorts) from the A4 (Anti-Amyloid Treatment in Asymptomatic AD) Study. In the tau positron emission tomography cohort, we used amygdalar segmentations to examine representative nuclei from 3 functional divisions of the amygdala. We analyzed between-group differences in division-specific tau binding in the amygdala in preclinical AD. We conducted seed-based functional connectivity analyses from each division in the functional magnetic resonance imaging cohort. Finally, we conducted exploratory post hoc correlation analyses between neuroimaging biomarkers of interest and anxiety and depression scores. ResultsAmyloid-positive individuals demonstrated increased tau binding in the medial and lateral amygdala, and tau binding in these regions was associated with mood symptoms. Across amygdalar divisions, amyloid-positive individuals had relatively higher regional connectivity from the amygdala to other temporal regions, the insula, and the orbitofrontal cortex, but medial amygdala to retrosplenial cortex connectivity was lower. Medial amygdala to retrosplenial connectivity was negatively associated with anxiety symptoms, as was retrosplenial tau. ConclusionsOur findings suggest that preclinical tau deposition in the amygdala and associated changes in functional connectivity may be related to early mood symptoms in AD.

ОРГАНИ ДЕРЖАВНОЇ ВЛАДИ ЯК СУБ’ЄКТИ ВІЙСЬКОВО-ТЕХНІЧНОГО СПІВРОБІТНИЦТВА

The article analyzes the issues of competence of public authorities as subjects of legal relations in the field of military-technical cooperation. Based on the functional division of state power, the structure of state authorities in the field of military-technical cooperation is considered. It is stated that the only legislative body in Ukraine is the Parliament, the Verkhovna Rada of Ukraine. The relevant government bodies, primarily the Cabinet of Ministers of Ukraine, represent the executive branch of government. Based on the functional approach, the author proposes a three-tier system of central executive bodies in the field of military-technical cooperation, which includes: Level I – the Cabinet of Ministers of Ukraine; Level II – ministries of Ukraine (Ministry of Defense, Ministry of Strategic Industries, Ministry of Finance); Level III – state services, state inspections, state agencies, independent regulators and bodies with special status (State Export Control Service, State Space Agency). It was noted that an advisory body should be established with the competence to deal with military-technical cooperation, namely: The Interagency Commission on Military-Technical Cooperation and Export Control Policy, which is an advisory body to the President of Ukraine. Key words: military-technical cooperation, international cooperation, subjects of legal relations, public authorities, military-industrial complex.