Abstract Background In medical education and particularly in public health, the shift toward active learning addresses the limitations of traditional lecture-based methods. Game-based learning, such as serious games, showed potential to overcome these limitations. “Accidémie” is a card game designed to improve medical students’ knowledge of home accidents and their competencies in public health through an interactive format. This study aims to evaluate the effectiveness of “Accidémie”. Methods We conducted a quantitative pre-post assessment study among sixth-year medical students of the University of Versailles. Data were collected through a 20-item true/false repeated questionnaire before and after. In addition, the post-intervention questionnaire included questions on students’ satisfaction and an open-ended question. Responses to the questionnaires were converted into scores. The main outcome measured was the change in the scores. The scores before and after the intervention are presented with their mean and standard deviation. They were compared using a paired t-test. Student satisfaction is presented in terms of frequency and includes verbatim responses from the students. Results Thirty-eight students participated, with pre-test scores averaging 13.13 (SD = 1.98) and post-test scores averaging 14.89 (SD = 1.94). A paired t-test provided statistical evidence of the difference between the pre- and post-test scores (p < 0.001). Students provided positive feedback: 81.6% of the students were very satisfied with the game; 42.1% considered it extremely useful. They also underlined that ‘Accidémie’ is an enjoyable learning tool, praising its innovative approach. Conclusions “Accidémie” improved students’ knowledge of home accidents and their engagement. It supports the use of serious games in medical education complementary to traditional methods. Applying the concept of “Accidémie” across various subjects and among diverse groups of health students offers promising prospects. Key messages • ‘Accidémie’ significantly improves students’ knowledge of home accidents, a public health topic. • “Accidémie” allows medical students to learn while playing, boosting satisfaction and engagement.