With the tremendous increase in wireless user traffic, investigation on the end-to-end reliability of wireless networks in practical conditions such as non-homogeneous fading channel conditions is becoming increasingly widespread. Because they fit well to the experimental data, generalized channel fading distributions like κ–μ are well suited for modeling diverse fading channels. This paper analyzes the symbol error rate (SER) and outage probability (OP) performance of multiple-input multiple-output (MIMO) space-time block-code (STBC) selective decode and forward (S-DF) network over κ–μ fading channel conditions considering the additive white Gaussian noise (AWGN). First, the closed-form (CF) analytical expressions for the probability density function (PDF) and the cumulative distribution function (CDF) of the received signal-to-noise ratio (SNR) as well as its moment generating function (MGF) are derived. Second, the OP performance is then investigated for various values of the channel fading parameter and SNR regimes. The simulation findings show an increase in SER performance with an improved line-of-sight (LOS) component. Furthermore, the results show that the S-DF relaying systems can function properly even when there is no fading or LOS component. The OP has been increasing with the increase in the value of μ and κ. In medium and high SNR regimes, simulation results exactly match with analytical results.