Diverse Approaches Research Articles

Unveiling impact measurement: navigating the evolving landscape in France

Purpose This article aims to explore the growing adoption of social impact measurement (SIM) among French Social and Solidarity Economy Organizations (SSEOs) in the context of a global drive for accountability. It examines the evolution of SIM, its implications, risks and methodological challenges. Key themes include the transition from “social utility” to “social impact,” the emergence of an impact-driven market, and concerns about the limitations of standardized measurement models. The paper calls for a diverse approach to evaluation, aiming to preserve the unique identities of SSEOs and promote innovation. Design/methodology/approach This comprehensive literature review, covering both academic and grey literature, explores the evolution of SIM in French SSEOs. It focuses on regulatory frameworks, stakeholder engagement and methodological principles to provide a thorough understanding of the implications and potential risks. Findings The findings highlight a major shift in public policy instruments, driven by the growing adoption of SIM within French SSEOs. While SIM methods offer opportunities, they also pose risks, such as the commodification of social impact, the rise of isomorphic practices and an overemphasis on performativity. Research limitations/implications The research implications emphasize the need to recognize how SIM affects the organizational identity of SSEOs and to foster discussions on alternative evaluation methods. A limitation of the study is its focus on French SSEOs, which may limit the generalizability of the findings to other contexts within the broader social economy sector. Practical implications The article provides valuable insights for policymakers, SSEOs and stakeholders on the role of SIM in the French social economy. It advocates for critical evaluation and policy alignment to improve the sector’s overall effectiveness. Social implications The social implications involve gaining a deeper understanding of how SIM practices affect the identity and operations of French SSEOs. By emphasizing risks such as commodification and isomorphic trends, the article encourages reflection on the broader societal impacts. Originality/value The article’s originality stems from its thorough exploration of SIM’s evolution within French SSEOs. Its value lies in shedding light on the complex relationship between SIM adoption, organizational identity and societal values, thereby encouraging informed decision-making and deeper discourse within the SSEOs landscape.

Energy Transfer for Constructing Circularly Polarized Luminescence Materials: Recent Progress and Future Prospects

AbstractCircularly polarized luminescence (CPL) materials hold significant promise in multidisciplinary fields such as circularly polarized organic light‐emitting diodes, biological probes, data storage, and information encryption. However, these cutting‐edge applications also put forward higher requirements for the design of CPL materials, requiring large dissymmetry factor and high emission quality. For this purpose, diverse approaches have been explored to generate and enhance CPL emission. Among them, energy transfer (ET) strategy stands out as it can be readily implemented in a wide range of CPL materials. The present work overviews latest advances in energy transfer for generating and modulating CPL, involving small organic molecules, polymers, metal complexes, liquid crystals, as well as new‐emerging chiral luminescent materials. It is anticipated that the review article will garner increased attention toward energy transfer systems and facilitate the advancement of CPL materials.

US State Recreational and Medical Cannabis Delivery Laws, 2024.

Objectives. To provide a legal epidemiology review of state-level policies that regulate the direct delivery of recreational and medical cannabis in the United States. Methods. We conducted a comprehensive review to identify all relevant policies as of July 1, 2024. Specifically, we developed a coding scheme to capture laws governing (1) direct delivery of recreational cannabis, (2) licensing for direct delivery of recreational cannabis, (3) direct delivery of medical cannabis to qualifying patients, and (4) medical cannabis delivery solely from caregivers to qualified patients. Results. Fourteen states authorized the direct delivery of recreational cannabis to adults. Twenty-six states and the District of Columbia permitted the direct delivery of medical cannabis to qualifying patients. Twelve states allowed the delivery of medical cannabis to patients exclusively through caregivers. There were numerous variations in the licensing and authorization of recreational and medical cannabis delivery. Conclusions. States varied in how the delivery of cannabis was regulated. Public Health Implications. A comprehensive review of state-level policies on cannabis delivery highlights the diverse approaches and their implications for recreational and medical cannabis access. (Am J Public Health. Published online ahead of print November 14, 2024:e1-e13. https://doi.org/10.2105/AJPH.2024.307874).

A guide for blood-brain barrier models.

Understanding the intricate mechanisms underlying brain-related diseases hinges on unraveling the pivotal role of the blood-brain barrier (BBB), an essential dynamic interface crucial for maintaining brain equilibrium. This review offers a comprehensive analysis of BBB physiology, delving into its cellular and molecular components while exploring a wide range of in vivo and in vitro BBB models. Notably, recent advancements in 3D cell culture techniques are explicitly discussed, as they have significantly improved the fidelity of BBB modeling by enabling the replication of physiologically relevant environments under flow conditions. Special attention is given to the cellular aspects of in vitro BBB models, alongside discussions on advances in stem cell technologies, providing valuable insights into generating robust cellular systems for BBB modeling. The diverse array of cell types used in BBB modeling, depending on their sources, is meticulously examined in this comprehensive review, scrutinizing their respective derivation protocols and implications. By synthesizing diverse approaches, this review sheds light on the improvements of BBB models to capture physiological conditions, aiding in understanding BBB interactions in health and disease conditions to foster clinical developments.

Gender and Authoritarian Politics: Citizens and Elites’ Responses to Gender Reforms

Scholarship investigating autocrats’ motivations to adopt gender equality reforms has proliferated. Yet, many questions remain unanswered: Who supports these gender reforms? Do citizens support gender quota policies? What is the role of political elites? Under what conditions do women’s increased presence in politics lead to positive outcomes for women? Answering these questions is crucial for both practical and empirical reasons. On the one hand, the number of ‘partly free’ and ‘not free’ countries is increasing, making up the majority of world countries (79%). On the other hand, women’s access to political power has exponentially grown over the past two decades. Women in autocracies are participating in politics more than ever before. This special issue presents cutting-edge research on gender and authoritarian politics relying on diverse methodological approaches and geographical foci. The introduction of this SI identifies the remaining knowledge gaps and provides future directions for more scholarship on the intersection of gender and authoritarian politics.

TMOD-10. ESTABLISHMENT OF ADULT AND PEDIATRIC BRAZILIAN PRE-CLINICAL MODELS FOR HIGH-GRADE GLIOMAS

Abstract High-grade gliomas (HGG) are the most aggressive brain tumors, necessitating robust and representative preclinical models for therapeutic research. We established primary cultures and patient-derived xenograft models from three pediatric high-grade gliomas (pHGG) and one adult IDH wild-type glioblastoma (GBM IDHwt) Brazilian patients. The first pHGG case, from an 11-year-old with PDGFRA (c.1977C>G) and TP53 (c.637C>T) mutations, led to the development of the HCB570 primary culture, PDX and patient-derived orthotopic xenograft (PDOX) OXP9. The second pHGG, from an 11-year-old with CMMRD syndrome and MSH6 germline mutation, resulted in the HCB589 primary culture, PDX and PDOX OXP22. The third pHGG case, from a 14-year-old with diffuse midline glioma harboring an H3F3A mutation, established the HCB604 primary culture and PDX OXP32. The HCB612 primary culture and PDX GBM1, were established from an adult patient with GBM IDHwt, TERT mutated, with no MGMT promoter methylated. The primary cultures showed varied proliferative rates, with an average doubling time of 55 hours. All cultures demonstrated colony-formating capability, with an average IC50 of 750µM for temozolomide (TMZ) exposure. Immunohistochemical and EPIC methylation profiles confirmed that the PDX models closely resemble the patient features. Our establishment of diverse preclinical models, including those derived from patients with rare genetic conditions such as CMMRD, provides valuable insights into HGG pathogenesis and potential therapeutic strategies. The present Brazilian patient-derived models enrich glioma research inclusion diversity and foster future personalized treatment approaches.

Advancements in the Engineering Modification of Sucrose Phosphorylase

Sucrose phosphorylase (SPase) is a member of the glycoside hydrolase family 13, catalyzing the reversible phosphorolysis of sucrose to produce α–glucose–1–phosphate and exhibiting transglycosylation activity toward multiple substrates. Its wide substrate specificity enables the synthesis of various glycosides, which are broadly applied in food, cosmetics, and pharmaceuticals. However, the industrial application of SPase is constrained by its poor thermostability and limited transglycosylation activity. Therefore, current research focuses on enhancing the thermostability and transglycosylation activity of SPase through efficient engineering strategies based on its crystal structure and catalytic mechanism. This paper systematically reviews the crystal structure and catalytic mechanism of SPase, outlines the application of protein engineering and immobilization strategies in improving the thermostability of SPase, and analyzes how modifications at key amino acid sites affect the synthesis of typical glycosylation products. It also summarizes the limitations of SPase engineering modification strategies and explores the potential of diversified approaches for SPase modification, highlighting its broad application prospects in industrial production and laying a solid foundation for further advancements in SPase engineering modification and its industrial application.

Resolving Disputes in International investment through Arbitration

This paper brings forth an extensive analysis of the role of arbitration in resolving disputes in international investment, providing a comparative study of the existing frameworks and emerging alternatives. As cross-border investments continue to grow, disputes between foreign investors and host states have become increasingly common. International arbitration has emerged as the preferred method for resolving such conflicts due to its neutrality, enforceability, and flexibility. The paper explores the key legal instruments governing international investment arbitration, including Bilateral Investment Treaties (BITs), Free Trade Agreements (FTAs), and multilateral agreements like the Energy Charter Treaty. It also examines the two most widely used procedural frameworks: the International Centre for Settlement of Investment Disputes (ICSID) and the United Nations Commission on International Trade Law (UNCITRAL), comparing their distinct approaches to arbitration. While arbitration has proven effective, it faces growing criticisms, including high costs, lengthy proceedings, and concerns about transparency and arbitrator impartiality. The research also highlights regional initiatives, particularly in Latin America and China, which reflect diverse approaches to investment dispute resolution. By comparing these frameworks and emerging trends, the paper sheds light on the strengths, weaknesses, and future direction of international investment arbitration, emphasizing the need for a more transparent, equitable, and accessible system to balance the interests of investors and host states. The analysis concludes by assessing the potential impact of these reforms on the future of international investment law.

Quantitative and Computational Spinal Imaging in Neurodegenerative Conditions and Acquired Spinal Disorders: Academic Advances and Clinical Prospects

Introduction: Quantitative spinal cord imaging has facilitated the objective appraisal of spinal cord pathology in a range of neurological conditions both in the academic and clinical setting. Diverse methodological approaches have been implemented, encompassing a range of morphometric, diffusivity, susceptibility, magnetization transfer, and spectroscopy techniques. Advances have been fueled both by new MRI platforms and acquisition protocols as well as novel analysis pipelines. The quantitative evaluation of specific spinal tracts and grey matter indices has the potential to be used in diagnostic and monitoring applications. The comprehensive characterization of spinal disease burden in pre-symptomatic cohorts, in carriers of specific genetic mutations, and in conditions primarily associated with cerebral disease, has contributed important academic insights. Methods: A narrative review was conducted to examine the clinical and academic role of quantitative spinal cord imaging in a range of neurodegenerative and acquired spinal cord disorders, including hereditary spastic paraparesis, hereditary ataxias, motor neuron diseases, Huntington’s disease, and post-infectious or vascular disorders. Results: The clinical utility of specific methods, sample size considerations, academic role of spinal imaging, key radiological findings, and relevant clinical correlates are presented in each disease group. Conclusions: Quantitative spinal cord imaging studies have demonstrated the feasibility to reliably appraise structural, microstructural, diffusivity, and metabolic spinal cord alterations. Despite the notable academic advances, novel acquisition protocols and analysis pipelines are yet to be implemented in the clinical setting.

Different sustainability endgames: Institutional logics in the performance management of local governments

IMPACT Local governments operate in institutionally complex environments where overlapping values, rules and priorities shape their actions. This article explores how such complexity directly impacts the production of sustainability performance information. By examining various institutional logics within local governments, the study highlights how these differing perspectives lead to diverse approaches in managing sustainability performance. The article introduces three potential ‘endgames’—sustainability as a brand, strategy or raison d’être—each representing a distinct path for integrating sustainable development goals (SDGs) into local governance. These endgames provide local government managers, specialists, and sustainability co-ordinators, with a framework to reflect on the priorities and rationales behind current sustainability performance management practices. This article is essential reading for those seeking to develop meaningful performance measurement for the SDGs.

Collectively Working towards Plant-Pollinator Interactions Data Interoperability and Reuse: Lessons Learned from the WorldFAIR Project

The WorldFAIR project worked with eleven case studies to advance the implementation of the FAIR data principles (Findable, Accessible, Interoperable, and Reusable; Wilkinson et al. 2016). The Case Study on Agricultural Biodiversity (Drucker et al. 2022) addressed the challenges of advancing interoperability and mobilizing plant-pollinator interaction data for reuse. In the first phase of the project we performed a landscape analysis and found that a significant amount of data on plant-pollinator interaction was available as supplementary files of research articles, in a range of formats such as PDFs, Excel® spreadsheets, and text files. The diversity of approaches and the lack of appropriate data vocabularies led to confusion, information loss, and the need for complex data interpretation and transformation. In the second phase of the project, we performed six studies to adopt standards recommended in the first phase. Our approach for plant-pollinator data standardization was based on Darwin Core (Darwin Core Task Group 2009) and Ecological Data Language (EML, Jones et al. 2019), in conjunction with a data model and vocabulary proposed by the Brazilian Network of Plant-Pollinator Interactions (REBIPP). The studies underwent a process of “FAIRification” (i.e., transforming data into a format that adheres to the FAIR data principles) using the Global Biotic Interactions (GloBI, Poelen et al. 2014) platform. Two studies also explored the publishing model for Biotic Interactions as part of the GBIF New Data Model. The standardization strategy was successful and increased the interoperability of plant-pollinator interaction data, resulting in a process that allows tracking the provenance of the data, as well as facilitates the reuse of datasets (Drucker et al. 2024). This effort led to the development of "FAIR best practices" and guidelines for sharing plant-pollinator interaction data, as well as a FAIR assessment tool designed to help researchers and institutions evaluate adherence to the FAIR principles (Drucker et al. 2024). A tutorial to standardize plant-pollinator datasets (Gonzalez-Vaquero et al. 2024) and a cookbook with guidelines and recommendations for publishing agriculture-related plant-pollinator data (Salim et al. 2024) were developed to help different actors standardize plant-pollinator interaction data in accordance with the FAIR principles. Moving from diverse approaches and siloed initiatives to widely available FAIR plant-pollination interaction data for scientists and decision-makers will enable the development of integrative studies that enhance our understanding of species biology, behavior, ecology, phenology, and evolution.

Preparing PhD Students for Tenure-Track Faculty Positions.

With an increasing number of nursing faculty approaching retirement, it is critical to prepare PhD students to take on tenure-track faculty roles. There are a multitude of competing time demands for nursing faculty, and one way that PhD students can prepare for faculty roles is leading team-based science with their peers during their predoctoral program. To describe the process of PhD students leading an independent research project, in addition to their dissertation work, which aimed to incorporate the tripartite mission- scholarship, teaching, and service. This paper outlines the components of the PhD-student-led project, as well as provides recommendations for leadership and schools of nursing as well as sponsors interested in funding this type of work. Students were able to conduct independent research using diverse research approaches, practice mentoring skills, and provide service and helpful information about the nursing workforce to their academic clinical partner. A key component of this relationship building was incorporating a clinical fellowship during the PhD program for students that directly aided the transition from BSN to PhD programs. PhD students learned valuable lessons about time management and collaborating in a team setting with peers. We recommend school of nursing seek funding opportunities for PhD students to conduct independent team science, encourage academic partnerships with affiliated medical centers and public health settings, and facilitate peer mentorship across cohorts.

Community-based reconstruction and simulation of a full-scale model of the rat hippocampus CA1 region.

The CA1 region of the hippocampus is one of the most studied regions of the rodent brain, thought to play an important role in cognitive functions such as memory and spatial navigation. Despite a wealth of experimental data on its structure and function, it has been challenging to integrate information obtained from diverse experimental approaches. To address this challenge, we present a community-based, full-scale in silico model of the rat CA1 that integrates a broad range of experimental data, from synapse to network, including the reconstruction of its principal afferents, the Schaffer collaterals, and a model of the effects that acetylcholine has on the system. We tested and validated each model component and the final network model, and made input data, assumptions, and strategies explicit and transparent. The unique flexibility of the model allows scientists to potentially address a range of scientific questions. In this article, we describe the methods used to set up simulations to reproduce in vitro and in vivo experiments. Among several applications in the article, we focus on theta rhythm, a prominent hippocampal oscillation associated with various behavioral correlates and use our computer model to reproduce experimental findings. Finally, we make data, code, and model available through the hippocampushub.eu portal, which also provides an extensive set of analyses of the model and a user-friendly interface to facilitate adoption and usage. This community-based model represents a valuable tool for integrating diverse experimental data and provides a foundation for further research into the complex workings of the hippocampal CA1 region.

Developing a Cloud and IoT-Integrated Remote Laboratory to Enhance Education 4.0: An Approach for FPGA-Based Motor Control

Remote laboratories are essential in addressing access and quality challenges in technical education. They enable students from various locations to engage with real equipment, overcome geographic and economic constraints, and provide solutions during crises, such as pandemics, when in-person learning is limited. As a key element of Education 4.0, remote labs promote technical skill development, enhance engineering education, and support diverse learning approaches. This study presents a remote laboratory based on Field Programmable Gate Arrays (FPGAs), developed using a waterfall methodology integrating IoT and Cloud Computing technologies to facilitate close interaction between hardware and software. The lab focuses on controlling DC, servo, and stepper motors, allowing students to apply theoretical concepts such as digital signals, pulse-width modulation (PWM), and data representation in bits in a practical setting. The testing phase involved 50 robotics and mechatronics engineering students who participated in hands-on sessions for one month, followed by a structured survey evaluating their experience, interaction, and the educational relevance of the platform. The survey shows high student satisfaction, highlighting the platform’s strengths and identifying areas for improvement. The results also underscore the system’s potential to significantly enhance the educational experience in remote environments, aligning with the United Nations Sustainable Development Goals (SDGs).

Evolution of treatment strategies for solid tumors with RET rearrangement in China and real-world treatment status of Non-small Cell Lung Cancer (NSCLC)

ObjectiveThe present study endeavors to furnish an exhaustive review of the research advancements on solid tumors harboring RET rearrangement within the Chinese context, particularly emphasizing the examination of real-world therapeutic strategies and clinical outcomes observed in individuals diagnosed with advanced non-small cell lung cancer (NSCLC). The review delves into a critical assessment of the therapeutic efficacy of targeted RET inhibitors, while also scrutinizing the diverse array of treatment modalities employed in the Chinese patient population.MethodsThe study conducted a comprehensive review of the advancements made by Chinese scholars in the realm of RET driver genes. It delved into the analysis of the incidence of RET rearrangements in solid tumors, alongside an examination of the varied treatment paradigms and their current status within China. Utilizing the RECIST 1.1 criteria, the study evaluated the therapeutic efficacy achieved in RET-positive NSCLC patients undergoing diverse treatment modalities. Furthermore, treatment-related adverse events (TRAEs) were meticulously graded following the Common Terminology Criteria for Adverse Events (CTCAE).ResultsA retrospective, multi-center, real-world analysis was conducted, encompassing 64 patients diagnosed with pathologically confirmed RET rearrangement advanced non-small cell lung cancer (NSCLC) between December 2015 and November 2023. Notably, KIF5B-RET emerged as the most prevalent RET fusion partner, accounting for 59.4% of cases. Therapeutic interventions among these patients included specific targeted inhibitors such as Pralsetinib (48.4%), chemotherapy (34.3%), multi-target inhibitors (15.6%), and one case (1.6%) involving immunotherapy combined with anti-angiogenic therapy. In terms of progression-free survival (PFS), Pralsetinib monotherapy demonstrated a median PFS of 16.03 months, outperforming chemotherapy (2.87 months; p < 0.0001), chemotherapy combined with anti-angiogenic therapy (6.90 months; p = 0.048), and multi-target inhibitors (2.50 months; p < 0.0001). Furthermore, the one-year and two-year overall survival (OS) rates for Pralsetinib monotherapy were 64.3% and 46.4%, respectively. Regarding safety, 71.0% of patients receiving Pralsetinib experienced at least one adverse event, with 45.2% classified as grade 3–4 in severity. Notably, no fatalities were attributed to adverse events. Common adverse events included hemoglobin reduction (35.5%) and neutropenia (32.3%), indicative of an overall favorable safety profile for Pralsetinib in this patient population.ConclusionThis study encapsulates the research endeavors and treatment advancements of RET rearrangement solid tumors within the Chinese healthcare landscape, specifically highlighting the diverse real-world therapeutic approaches and their effectiveness in managing advanced RET rearrangement NSCLC among Chinese patients. Notably, targeted RET inhibitors like Pralsetinib have emerged as potent therapeutic agents, exhibiting remarkable efficacy and a manageable safety profile in this patient cohort. These findings underscore the potential of Pralsetinib and similar targeted therapies as novel treatment options for individuals with RET fusion-positive NSCLC.

A Review on Mixed Reality Operating Systems : Current Trends, Challenges and Prospects

This comprehensive article explores the rapidly evolving landscape of Mixed Reality (MR) operating systems, examining their core functionalities, architectural components, and the cutting-edge trends shaping their development. The article provides an in-depth analysis of the challenges facing MR OS developers, including interoperability, scalability, and user experience optimization, while offering insights into potential solutions. A comparative article of leading MR platforms highlights the diverse approaches and capabilities within the current ecosystem. The article delves into future prospects, discussing the integration of artificial intelligence, advanced user interaction paradigms, and their potential impact across various industries. Additionally, it addresses strategies for overcoming current limitations and explores the broader implications of MR technology on society, including ethical considerations and privacy concerns. By synthesizing current research and industry developments, this paper offers a comprehensive overview of the state of MR operating systems, their potential applications, and the transformative role they are poised to play in shaping human-computer interaction and digital experiences. The article concludes by emphasizing the critical importance of continued innovation in MR operating systems for advancing the field and realizing the full potential of mixed reality technology in both personal and professional domains.

PENGUATAN NILAI-NILAI MODERASI BERAGAMA MELALUI PENDIDIKAN PASRAMAN NONFORMAL

The background of this study highlights the pervasive threat of radicalism and intolerance within the educational environment, impacting a portion of students and scholars with anti-Pancasila views, thereby posing a danger to social harmony. Urgent measures are necessary to address this situation before more widespread damage occurs. Employing a qualitative and exploratory approach, this research aims to develop an educational framework within the Non-Formal Pasraman in West Lombok Regency, West Nusa Tenggara Province. Both primary and secondary data are collected and analyzed using an inductive method. In efforts to curb radicalism, Pasraman adopts a preventive approach, focusing on the soft approach. Strategies such as introducing moderation values, exhibiting positive behavioral models, interfaith dialogue, active learning, and engaging in social services are identified as means to fortify the inculcation of religious moderation values. Strategic recommendations to enhance the quality of religious moderation education in non-formal Pasraman involve improving teacher qualifications, collaborating with relevant institutions, developing pertinent learning resources, and fostering inclusive and diverse educational approaches

Ten Answers: Why Multiplying Two Negatives Is Positive

Why does multiplying two negative numbers result in a positive number? Here are ten diverse instructional approaches teachers can use to help students understand and explain this concept.

A literature review on corporate governance and ESG research: Emerging trends and future directions

Extant research emphasizes that corporate governance (CG) significantly influences environmental, social, and governance (ESG) outcomes. This paper undertakes a content analysis and reviews 91 academic articles published in 41 journals over the past 14 years (2010-2023). We examine the role of CG in ESG outcomes by focusing on CG themes, ESG indicators, theories, countries, and empirical methodologies used to address endogeneity. The findings show that several factors collectively impact ESG outcomes positively. Such factors include female directors, institutional investors, independent directors, CEO characteristics, directors' compensation, and sustainability committees. Relatedly, the findings also suggest that family ownership may potentially exert a detrimental effect on ESG performance. Despite the burgeoning evidence on CG and ESG outcomes, we highlight several understudied areas, such as directors' ESG expertise in specific ESG-related sectors and CEO tenure. Furthermore, we call for more research focusing on non-financial firms, particularly in European countries. Given the current studies' reliance on archival methodologies, we encourage future research to adopt diverse approaches, such as qualitative and mixed research methods. Finally, we discuss several research avenues, identify gaps in the literature, and outline a future research agenda.

Anesthetic Techniques for Type-1 (Medialization) Thyroplasty: A Scoping Review

ObjectiveTo explore different anesthesia techniques for medialization thyroplasty and determine how these anesthesia techniques may influence patient safety, patient experience, and surgical outcomes during medialization thyroplasty in adult patients. Data SourcesA comprehensive librarian-designed strategy was used to search EMBASE, MEDLINE, and Web of Science for English language studies from database inception to July 2023. The study was registered on Open Science Framework (10.17605/OSF.IO/R3BV2). Review MethodsStudy selection was independently performed by two investigators for all English language studies of adult patients investigating anesthetic techniques for medialization thyroplasty with a minimum of 5 patients. Surgical outcomes (voice, perioperative complications, swallowing), healthcare resource utilization metrics (operating time, length of stay), and patient-reported outcomes measures (PROMs) were analyzed. Study quality was assessed with the Oxford Levels of Evidence tool. ResultsFrom 354 articles, 28 studies were included. The most common anesthetic techniques were combined procedural sedation and local anesthesia (13/28[46%]), local anesthesia alone (8/28 [29%]), and general anesthesia (GA) (7/28 [25%]). Six (6) studies (21%) reported intraoperative complications (e.g., desaturation), and 8 (29%) studies reported postoperative complications (e.g., airway obstruction). Voice outcomes were assessed in 14 (50%) studies. PROMs, including Voice Handicap Index (3/28 [11%]) were less commonly assessed. Intraoperative fiberoptic visualization was utilized in 8 (29%) studies. Only one study assessed swallowing. Only two studies compared outcomes between anesthetic techniques. The median Oxford Level of Evidence was 4. ConclusionMedialization thyroplasty is performed under local anesthetic alone, with combined procedural sedation, and local anesthetic or with GA, with diverse approaches to airway management and minimal perioperative complications. Future research using standardised outcome measures is warranted due to the current paucity in the literature.