The middle and lower reaches of the Yangtze River are frequently affected by the Western Pacific Subtropical High (WPSH) in summer. This leads to phenomena including air subsidence, high temperatures, low rainfall, and weak winds, all of which affect the urban heat island (UHI) effect. Currently, there are few studies on the influence of WPSH on the UHI effect. In this study, we analysed the temporal and spatial distributions of the influence of WPSH on the UHI effect by establishing two scenarios: with and without WPSH. We calculated the UHI intensity and the urban heat island proportion index (UHPI) to analyse the temporal and spatial distributions of the UHI effect. The geographical detector method was then used to analyse the factors influencing UHI. The results indicate the strong heat island effect during the day in provincial capitals and some developed cities. The area of high UHI intensity was larger under the influence of WPSH than in the years without WPSH. WPSH affected UHPI at both day and night, although the effect was more pronounced at night. The factors affecting daytime UHI intensity are mainly POP and NTL, O3 plays a large role in the years with WPSH control. The main factors affecting the UHI intensity at night are AOD, POP and NTL were mainly factors in the years without WPSH control, POP and WPSH were mainly factors in the years with WPSH control. The interactions of the factors are mainly POP and multi-factors during the daytime, and DEM and multi-factors during the nighttime. It was found that the UHI intensity was enhanced under the control of the WPSH, and the influencing factors of the diurnal UHI differed with and without the WPSH control, which ultimately provides realistic suggestions for mitigating the intensity of the UHI in areas affected by the WPSH.