Distribution Curves Research Articles

Original ArticleAssociation between GLIM-diagnosed malnutrition and quality of life in older patients with cancer

BackgroundOlder patients with cancer have a higher risk for malnutrition and impaired quality of life (QoL). The present study aimed to investigate the relationship between malnutrition diagnosed according to the Global Leadership Initiative Malnutrition (GLIM) criteria and QoL across various tumor types, and to evaluate the combined prognostic value of malnutrition and QoL in predicting survival among older patients with cancer. MethodsThis multicenter, observational cohort study included 5310 older patients with cancer and 2184 with malnutrition (moderate stage, n = 1023; severe stage, n = 1161). An empirical cumulative distribution curve was performed to illustrate the correlation between malnutrition and QoL. The primary objective was to investigate the association between malnutrition and QoL using logistic regression analysis. Survival analyses were performed to assess the combined prognostic value of malnutrition and QoL. ResultsThe median age of the patients (66.9% male, 33.1% female) was 70 years (interquartile range [IQR] 67–74 years) years. The median QoL score was highest in patients without malnutrition (91.88 [IQR 84.44–97.44]), followed by those with moderate (86.15 [IQR 76.18–93.85) and severe (82.31 [IQR 69.87–91.11]) malnutrition. Logistics regression revealed that the risk for developing impaired QoL increased 1.98 (95% confidence interval [CI] 1.64–2.38; P < 0.001) and 2.33 (95% CI 1.93–2.81; P < 0.001) times in patients with moderate and severe malnutrition, respectively. Kaplan–Meier curves showed that QoL in combination with GLIM criteria demonstrated a significant discriminative performance for survival and served as an independent prognostic factor among older patients with cancer, especially for lung and gastric cancers. ConclusionsMalnutrition diagnosed according to the GLIM criteria was a predictor of impaired QoL. Additionally, the combination of QoL and malnutrition demonstrated utility for predicting survival outcomes in older patients with cancer.

#2253 The gender influence on peritoneal membrane transport

Abstract Background and Aims The classification of peritoneal dialysis (PD) patients based on their peritoneal transport was introduced by Twardowski in 1987, analysing a cohort of 86 PD patients, where gender was not specified. Method Aiming to analyze gender differences in the interpretation of peritoneal transport outcomes, we completed a single-center cross-sectional study of 143 incident patients in PD between 2015 and 2022. We also, assessed differences in their follow-up outcomes until PD cessation (21.2 ± 17 months). Results We analyzed 143 patients (55.3 ± 15.5 years, 92% hypertension, 25.5% diabetic, Charlson index 5.9 ± 2.4 points), corresponding to 85 men (M) and 58 women (W). M were older (M 56.4 ± 15.4 years vs. W 53.7 ± 15.7 years, NS) and associated higher comorbidity (hypertension M 95.8% vs. W 86.4%, p = 0.04 and diabetes M 33.7% vs. W 13.6%, P = 0.007, NS on Charlson index) compared to W. Creatinine transport in W is slower than in M (D/P Cr M 0.73 ± 0.1 vs W 0.69 ± 0.1, p = 0.017), but no differences in glucose transport were observed. Although most patients were classified as medium-high transporters, the percentage of M was significantly higher than W (H 71.1% vs M 52.6%). In our cohort, initial adequacy tests using incremental PD reveal that W have a higher total Kt/v (M 2.2 ± 0.5 vs W 2.8 ± 1.9, p = 0.021) attributed to a higher peritoneal Kt/v (M 0. 95 ± 0.41 vs. W 1.3 ± 1.1, p = 0.035) and renal Kt/v (NS). Despite W presented lower residual renal function (NS) and lower residual diuresis (H 1.5 ± 0.7 L vs. M 1.3 ± 0.6 L) compared with M. There was no gender difference in average duration of PD (M 22.4 vs. W 21.5 months). However, most W ended PD to receive a kidney transplant (46.8%), while most M transitioned to haemodialysis (41.3%). Nineteen patients died during follow-up, with 68.4% being M (NS). Conclusion Differences in D/P Cr and normal distribution curves between M and W suggest significant differences in peritoneal membrane transport. Classical methods of assess PD quality and adequacy may need to be corrected by gender, further studies are needed to determine these differences.

Swelling pressure of phyllite residual soil during saturation

Phyllite residual soil is a typical regional soil formed from the weathering of phyllite rock formations, characterized by poor engineering properties. The swelling pressure could pose a threat to roadbed stability and other geological engineering disasters during the rainy season. Therefore, studying the swelling pressure of phyllite residual soil is critical for ensuring the sustainable development of both human society and the natural environment. In this study, a series of swelling pressure tests were conducted on the phyllite residual soil to determine its swelling pressure, and nuclear magnetic resonance (NMR) test was applied to assess the evolution of soil fabric in both the initial unsaturated state and saturated state. The results indicate that the swelling rate of phyllite residual soil is negatively correlated with the initial water content and positively correlates with the dry density. The denser or drier the phyllite residual soil is in its initial state, the higher the equilibrium swelling pressure will be. The analysis of T2 distribution curves reveals that during the wetting process in phyllite residual soil, water fills micropores prior to macropores until water fills up all pores.

Radial vibration measurement of rotating shaft using constant density fringe pattern and line scan camera

The radial vibration signals of the rotor can provide abundant information about the health condition of the machine. In this paper, a simple vision-based measurement system is proposed to simultaneously measure two-dimensional displacements in radial directions for the rotating shaft, where the system consists of a constant density fringe pattern (CDFP), a line scan camera (LSC), and a lens. The CDFP should be installed around the surface of the rotating shaft to make the density of the fringe constant along the shaft axis, while the shaft axis is vertical to the optical axis of the LSC but not parallel to the line-array sensor of the LSC. Therefore, the density of the fringe imaged on the LSC is not constant because of the modulation of the circular surface of the shaft, and the distribution of the fringe density on the LSC is a U-shaped curve. Thus, the shaft centreline orbit can be tracked by the lowest point of the density distribution curve (DDC) of the fringe. Then, an efficient and accurate parameterized instantaneous frequency estimation method is employed to estimate the DDC of the fringe, because the variable density fringe can be regarded as an amplitude-modulated and frequency-modulated nonstationary signal whose instantaneous frequency function is equivalent to the DDC. Experimental results verify the feasibility and effectiveness of the proposed method by comparing it to the eddy current sensors.

Effects of acute toxicity of the pesticide Chlorpyrifos and the metal Cadmium, both individually and in mixtures, on two species of native neotropical cladocerans.

The excessive use of pesticides in agriculture and the widespread use of metals in industrial activities and or technological applications has significantly increased the concentrations of these pollutants in both aquatic and terrestrial ecosystems worldwide, making aquatic biota increasingly vulnerable and putting many species at risk of extinction. Most aquatic habitats receive pollutants from various anthropogenic actions, leading to interactions between compounds that make them even more toxic. The aim of this study was to assess the effects of the compounds Chlorpyrifos (insecticide) and Cadmium (metal), both individually and in mixtures, on the cladocerans Ceriodaphnia rigaudi and Ceriodaphnia silvestrii. Acute toxicity tests were conducted for the compounds individually and in mixture, and an ecological risk assessment (ERA) was performed for both compounds. Acute toxicity tests with Cadmium resulted in EC50-48 h of 0.020 mg L-1 for C. rigaudi and 0.026 mg L-1 for C. silvestrii, while tests with Chlorpyrifos resulted in EC50-48 h of 0.047 μg L-1 and 0.062 μg L-1, respectively. The mixture test for C. rigaudi showed the occurrence of additive effects, while for C. silvestrii, antagonistic effects occurred depending on the dose level. The species sensitivity distribution curve for crustaceans, rotifers, amphibians, and fishes resulted in an HC5 of 3.13 and an HC50 of 124.7 mg L-1 for Cadmium; an HC5 of 9.96 and an HC50 of 5.71 μg L-1 for Chlorpyrifos. Regarding the ERA values, Cadmium represented a high risk, while Chlorpyrifos represented an insignificant to a high risk.

Composite Electromagnetic Scattering Characteristics of Actual Terrain and Moving Rockets

This research involved studying the characteristics of composite electromagnetic scattering from a rocket moving above actual terrain using the finite-difference time-domain method. The angular distribution curve of the composite scattering coefficient was obtained, and the influences of factors such as the angle of incidence, the frequency of the incident electromagnetic wave, the content of moisture in soil, the dielectric constant of the rocket-shell material, the height of the rocket, and the undulation of the terrain on the composite scattering coefficient were investigated. Results show that the composite scattering coefficient oscillates with the scattering angle and increases in the direction of mirror reflection. It also decreases with increasing angle of incidence, frequency of the incident wave, and altitude of the rocket, while it increases with increasing soil moisture and dielectric constant of the rocket-shell materials. Although the influence of different terrain undulations on the composite scattering coefficient is noticeable, it follows no fixed pattern.

Prediction of residual performance of corroded RC beams from observed surface cracks by 3D RBSM with MPC

Corrosion of reinforcing steel in concrete structures can significantly compromise their performance. Accurately estimating this deterioration for in-service structures is challenging due to uncertainties surrounding the distribution of internal corrosion and cracking patterns, compounded by the limitations of destructive testing. This research proposes a novel approach to predict the remaining load-bearing capacity of corroded reinforced concrete (RC) structures based on the pattern of surface cracks caused by corrosion. The method integrates a model predictive control (MPC) algorithm with a three-dimensional Rigid Body Spring Model (3D RBSM) to estimate internal corrosion levels from observed cracks and a normal 3D RBSM simulation to predict the residual performance. The proposed system is validated through analysis of four corroded beam specimens based on experimental work reported in the literature. In use, the MPC algorithm first estimates a corrosion distribution in a RC beam and generates simultaneous corrosion-induced crack and stress predictions. This information is then used to predict residual load-bearing capacity. The system accurately forecasts the non-uniform corrosion distribution, flexural capacity, and load-displacement curves of a specimen, offering insight into the performance differences among the specimens and demonstrating its potential to assess the serviceability of existing RC structures with corrosion issues.

Assessment of depositional environmental factors in quaternary sediments: a case study of Thamirabarani River basin, Srivaikundam region of southern India

This study uses a thorough grain size analysis approach to the depositional environment in the Thamirabarani River basin, specifically in the Srivaikundam district of Tamil Nadu, India. There is a significant lack of research on the depositional settings and sediment features unique to the Thamirabarani River basin, even though there have been numerous sediments studies conducted in other river basins. Consequently, the purpose of this study is to investigate the depositional habitats and sediment characteristics of this area. The majority of the 18 sediment samples were determined to be medium- to fine-grained and poorly sort-able after extensive analysis using granulometric research and sieve methods. The low-energy formation process took place in a largely fine-grained or very fine-grained sandy soil, as indicated by the sediments platykurtic and mesokurtic morphologies. The depositional habitats within the region can be better understood by classifying the soil based on ternary plots of clay, silt, and sand, such as particle distribution curve. Furthermore, comparison with a unified soil classification chart aids in further categorizing the soil types. Soils can be classified and the depositional settings of different landscapes, such as rivers, estuaries, beaches, and aeolian terrains, can be better understood with the use of this comprehensive grain size study. Another interesting aspect of the Thamirabarani River basin sediment movement and deposition is the slow breakdown of rocks, especially feldspar and quartz, as they move through rivers and streams.

Optimal Planning of Energy Storage in Distribution Feeders Considering Economy and Reliability

Optimal Planning of Energy Storage in Distribution Feeders Considering Economy and Reliability

Comparison of Fluid Flow and Tracer Dispersion in Four-Strand Tundish under Fewer Strand Casting and Sudden Blockage of Strand Conditions

The study focuses on the four-strand tundish as the research object, aiming at the phenomenon of fewer strand casting (stable blockage) and sudden blockage of the tundish in industrial production. Numerical simulation methods are employed to compare the velocity vectors, flow fields, residence time distribution (RTD) curves, and outflow percentage curves under stable blockage and sudden blockage of the tundishes with a double-weir structure, U-shaped weir structure, and U-shaped weir structure with holes in the front. The results indicate that, after sudden blockage of the tundish strands, the flow field transitions from an unstable four-strand flow field to a stable three-strand flow field. Both the double-weir tundish and the U-shaped weir tundish reach a stable state after 200 s, while the U-shaped weir tundish with holes in the front reaches stability after 150 s. Additionally, compared to other structures, the tundish strands of the U-shaped weir with holes in the front are less affected by blockage, showing better consistency among strands and better adaptability under non-standard casting conditions.

Study on the Influence of Particle Size Distribution on the Separation of Pyrite from Coal Gangue by Jigging

Study on the Influence of Particle Size Distribution on the Separation of Pyrite from Coal Gangue by Jigging

Electric Susceptibility at Partial Coverage of a Circular One-Side Access Capacitive Sensor with Rigid Polyurethane Foams.

The capability of dielectric measurements was significantly increased with the development of capacitive one-side access physical sensors. Complete samples give no opportunity to study electric susceptibility at a partial coverage of the one-side access sensor's active area; therefore, partial samples are proposed. The electric susceptibility at the partial coverage of a circular one-side access sensor with cylinders and shells is investigated for polyurethane materials. The implementation of the relative partial susceptibility permitted us to transform the calculated susceptibility data to a common scale of 0.0-1.0 and to outline the main trends for PU materials. The partial susceptibility, relative partial susceptibility, and change rate of relative partial susceptibility exhibited dependence on the coverage coefficient of the sensor's active area. The overall character of the curves for the change rate of the relative partial susceptibility, characterised by slopes of lines and the ratio of the change rate in the centre and near the gap, corresponds with the character of the surface charge density distribution curves, calculated from mathematical models. The elaborated methods may be useful in the design and optimization of capacitive OSA sensors of other configurations of electrodes, independent of the particular technical solution.

Experimental study on the bond-slip behavior of steel tube-coal gangue concrete

This study investigated the bond-slip behavior at the interface between steel tubes and coal gangue concrete, considering the coal gangue coarse aggregate replacement rate, the strength grade of coal gangue concrete, and the bond length as variable parameters. Eleven groups of push out tests were conducted on steel tube coal gangue concrete specimens. The bond slip curve and the longitudinal strain distribution curve of the steel tubes were obtained, and the effects of these parameters on bond strength were analyzed. The results showed that the load-slip curves at both the loading and free ends of the specimens were similar, with slip occurring earlier at the loading end. The regularity of the test curves in repeated experiments indicated that interfacial bond stress was primarily determined by friction in the later stages. The longitudinal strain of steel tubes was approximately exponentially distributed along their length. The interfacial bond strength increased with the increase of coal gangue aggregate replacement rate and was more pronounced in specimens with higher strength coal gangue concrete. Longer bond lengths resulted in greater bond failure loads, with a lower rate of increase in higher strength coal gangue concrete specimens compared to those with lower strength. Based on the three stage bond stress-slip relationship for steel tube-concrete, a bond-slip constitutive model for steel tube-coal gangue concrete was established. This provided a reference for mechanical analysis and interface performance design of steel tube-coal gangue concrete.

Standard series of transmitting equipment for hydra-jet technology based on dimensionless geometric parameters development

Introduction. The work is devoted to the calculation of series standards for the design of high-pressure transmission devices used in various hydra jet technologies, which will provide the design of these devices based on dimensionless indicators describing the relationship between their geometric and technological parameters.Materials and methods. The methodology includes the use of mathematical models and analytical approaches to assess the influence of various parameters on heat generation processes in equipment, as well as methods for statistical processing of results.Results. A histogram of temperature distribution was constructed and the data was approximated using the distribution curve of temperature values and parametric series were generated for dimensionless parameters depending on various factors such as temperature, pressure, rotational speed and linear speed. It is possible to obtain parametric series for linear dimensions from five temperature ranges and seven standard sizes depending on the pressure and rotation speed of the drill shaft.Discussion and conclusions. The results obtained provide a better definition of the relationships between rotation speed, geometric characteristics and temperature parameters through the use of dimensionless indicators and it is possible to optimize the design of such devices taking into account operating conditions and ensuring increased efficiency.

Rotated Lorenz Curves of Biological Size Distributions Follow Two Performance Equations

Rotated Lorenz Curves of Biological Size Distributions Follow Two Performance Equations

Breakage Indices for Constitutive Models to Track the Evolution of Particle Crushing Under Continuous Shearing

AbstractResearchers have developed numerous breakage indices, predominantly relying on comparisons between pre- and post-test Grain Size Distribution (GSD) curves determined through conventional sieve analysis. Although these indices enable a precise estimation of particle breakage extent, a significant limitation arises when attempting to integrate them into constitutive models, especially when those models cannot consider GSD as an input. This paper addresses the need for tailored breakage indices designed to suit the specific requirements of different families of constitutive models. The new indices have been developed based on stress and strain tensor invariants or combinations thereof, ensuring the future ease of implementation into various constitutive models. The proposed equations have been validated using five different sets of experiments performed on rockfill material, calcareous, and quartz sands. The comparison between the available experimental data and the estimated degree of particle breakage using the suggested indices demonstrates their adequate performance. The novel indices can be integrated into different constitutive models, including hypoplastic, elastoplastic, and thermodynamically consistent approaches, as well as tested for their practical applicability for boundary value problems.

Phosphorescence of beta irradiated Sr4Al14O25:Eu2+,Dy3+ ─ A persistent luminescence phosphor

Phosphorescence of beta irradiated Sr4Al14O25:Eu2+,Dy3+ has been analysed. The persistent luminescence that defines this phosphor is phosphorescence hence the justification for this study. A set of phosphorescence decay curves were measured at various temperatures Tph between 20 and 352 °C following irradiation to 2 Gy. The residual thermoluminescence (R-TL) was recorded at 1 °C/s after the phosphorescence decay. A conventional TL glow curve recorded at the same rate following irradiation to 2 Gy produces two composite glow peaks P1 and P2 at 63 and 252 °C respectively. The decay curves measured between Tph = 28–60 °C and 200–240 °C associated with peaks P1 and P2 respectively give the values of the activation energy of peaks P1 and P2 as 0.59 ± 0.01 and 0.80 ± 0.04 eV. The effective frequency factors associated with the traps are 6.2 × 109 and 6.4 × 105 s−1 respectively. Peaks P1 and P2 are affected by thermal quenching with activation energy W = 0.69 ± 0.06 eV and 0.66 ± 0.03 eV respectively. The R-TL glow curves show two maxima R1 and R2 at ∼72 and 260 °C respectively. Kinetic analysis of R-TL peak R2 shows a Gaussian distribution of trap energy whereas the same analysis on R-TL peak R1 shows a non-Gaussian distribution of trap energy. The mean values of activation energy corresponding to the respective electron traps of R1 and R2 are estimated to be 0.62 ± 0.07 and 1.04 ± 0.06 eV. For peak R2, the Gaussian distribution curve shows the maximum at ∼1.06 eV which indicates that most electron traps corresponding to peak R2 have this trap depth.

Robotic-assisted free flap harvesting for diverse soft tissue reconstruction: a PRISMA scoping review of clinical outcomes over the last decade.

The aim of our study was to assess the advantages and limitations of robotic technology in diverse reconstructive procedures. A scoping review was conducted in Oct'23, on published studies from 2013 to 2023, focussing on robotic-assisted free flap harvesting. Three databases Ovid-MEDLINE, Scopus, and PubMed were searched. Original research studies reporting robotic-assisted free flap harvest were included. Studies on lesion excision, microvascular anastomosis, local flap harvest, roboticassisted flap inset, review articles, abstract-only studies, non-English documents, and animal studies were excluded from this review. Sixteen studies met the inclusion criteria out of a total of 318, searched initially. These studies included a total of 128 patients, who underwent robotic-assisted free flap harvest for the reconstruction of various defects, with 140 free flaps harvested. The most common flaps harvested by robotic technique were deep inferior epigastric artery perforator (DIEP) flap 120 (85.7%), radial forearm free (RFF) flap 11 (7.9%), latissimus dorsii flap 4 (2.9%), rectus abdominus flap 4 (2.9%), and omental flap 1 (0.7%). Breast reconstruction was the major procedure done i.e. 120 (85.7%) followed by head and neck 11 (7.9%) and limb defects 9 (6.4%) reconstruction procedures. The reported clinical outcomes were acceptable in all the studies with a 99% flap success rate and minimal complications. Variability in operating time was observed depending upon surgical steps undertaken with robotic systems. This scoping review highlights the role of robotic-assisted free flap harvesting in plastic surgery and its potential benefits on clinical outcomes, due to its high precision and minimal invasiveness. However, challenges like cost effectiveness, resource distribution and learning curve are there.

Autoantibodies against Endophilin A2 as a novel biomarker are beneficial to early diagnosis of breast cancer

BackgroundDue to the lack of early symptoms, breast cancer is frequently overlooked, leading to distant metastases and multi-organ lesions that directly threaten patients’ lives. We have identified a novel tumor marker, antibodies to endophilin A2 (EA2), to improve early diagnosis of breast cancer. MethodsAntibody levels of EA2 were analyzed in sera of patients with cancers of different origins and stages by indirect enzyme-linked immunosorbent assay (ELISA). Diagnostic accuracy and reference range were determined by the area under the receiver operating curve and distribution curve. The levels of EA2 antigen in sera were determined by sandwich ELISA. ResultsThe levels of antibodies against EA2 were higher in sera of patients with breast cancer (P < 0.0001), liver cancer (P = 0.0005), gastric cancer (P = 0.0026), and colon cancer (P = 0.0349) than those in healthy controls, but not in patients with rectal cancer (P = 0.1151), leukemia (P = 0.7508), or lung cancer (P = 0.2447). The highest diagnostic value was for breast cancer, particularly in early cases (AUC = 0.8014) and those with distant metastases (AUC = 0.7885). The titers of EA2 antibodies in sera were correlated with levels of EA2 antigen in breast cancer patients. ConclusionAntibodies to EA2 are novel blood biomarkers for early diagnosis of breast cancer that warrants further study in larger-scale cohort studies.

Rainfall analysis and deriving design storm for hydrological modelling of Koyna dam catchment area in Maharashtra state of India

Rainfall is a key hydro meteorological variable. Climate change is disrupting the hydrological cycle and altering the usual cycle of rainfall, which frequently results in long-lasting storms with significant rainfall. A first step in hydrologic design of project is to determine the design storm or rainfall events to be used. For deriving design storm, researchers concluded that instead of using generalized readily available curves or maps, it is better to estimate design storm based on site specific historical rainfall data. The objective of the study is to analyze the rainfall data in the koyna watershed area in order to evaluate the design storm, which will be further used as an input data for HEC-HMS event based hydrological modelling of flood peak attenuation of design storm flow at koyna dam during extreme rainfall event.In this study, 40 years (1982–2021) of rainfall data from 8 rain gauge stations in Koyna Dam Catchment area is used initially for performing trend analysis through statistical and graphical techniques and then for Isopluvial analysis. The Sen's slope test and the Mann-Kendall test are the statistical techniques employed, and Innovative Trend Analysis is the graphical technique used. IDF approach is used for deriving design storm, and using Gumbel's frequency distribution method Isohyetal maps, IDF tables and curves are prepared for 2,10,25,50,75 and 100 year return periods and 6,12,24,48 and 96 h durations. Results obtained from statistical and graphical trend analysis of annual rainfall series are consistent. No statistically significant trend in annual rainfall series is observed, however there is rising and falling trend was observed in annual as well as monthly rainfall series.From the results of design storm study, the design storm hyetograph of 10 years return period and 96 h duration is selected, which gives the rainfall intensity of 10.88 mm/h for the koyna catchment. There are various dams nearby koyna catchment, The Isohyet maps, IDF curves and table output available from this study can be more reliably used during planning and design of hydraulic structure for other areas near by koyna catchment.