ABSTRACT The mathematical modeling of biological fluids holds paramount importance, given its diverse applications in the medical field. Understanding the peristaltic mechanism is crucial for gaining insights into various biological flows. This study focuses on numerically estimating the double-diffusive peristaltic flow of a non-Newtonian six constant Jefferys nanofluid within an irregular medium. The investigation considers the influences of nonlinear thermal emission, viscous dissolution, and induced magnetization, incorporating multiple slip conditions. The Buongiorno model is employed to underscore key features related to thermophoresis and Brownian diffusion coefficients. The convection of double diffusivity is elucidated through the Soret and Dufour variables. Lubrication technique is employed for mathematical simulation, and the resulting nonlinear coupled system of differential equations is solved numerically through the Mathematica program’s built-in command (ND Solve function). The graphical representation of the impact of crucial flow variables, such as nanoparticle volume proportion, pressure gradient, solute density, temperature, pressure fluctuation per wavelength, and velocity distribution, provides valuable insight. The findings of the current study show that an increase in the Prandtl number and thermophoresis parameter leads to the expansion of thermal curves. Moreover, it is also noted that rising heat frequencies of radiation cause the concentration of nanoparticles to increase.
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