Distribution Of Gc Subtypes Research Articles

Distribution of GC-subtypes in a series of chronic alcoholics.

This article reports on the distribution of GC-(group specific component) subtypes in a series of chronic alcoholics (N = 100). The determination of the phenotypes was carried out by immunoblotting. The results are interpreted and discussed. We observed no association between alcoholism and GC-subtypes.

Distribution of Gc subtypes in Aragon (north-east Spain).

Group-specific component (Gc) polymorphism was investigated in 559 individuals from Aragon. The gene frequencies were compared to those reported for other European populations.

On the variability of Gc subtypes in Italy.

909 individuals from different places of Italy were analyzed for the distribution of Gc subtypes. The observed heterogeneity in the distribution of the allele frequencies was found to be statistically significant. Comparing our results with those reported by other authors it is seen that within Italy a considerable regional variation in the frequencies of the Gc subtype alleles is present. However, there are no indications for any particular distribution patterns or gradients. In one of our samples (Bari district), one case of Gc 1S-1C3 was found.

7.10. Distribution of Gc subtypes by isoelectric focusing in Sweden

7.10. Distribution of Gc subtypes by isoelectric focusing in Sweden

Group-specific component (Gc) subtypes in the Chinese population of Hong Kong.

The distribution of Gc subtypes in a sample of the Chinese population of Hong Kong was studied using isoelectric focusing followed by immunofixation. A sensitive modification of this technique is described. Nine distinct phenotypes were observed which appear to result from the three common alleles Gc1F, Gc1S, and Gc2, which are found in most populations. The respective gene frequencies were 0.494, 0.258, and 0.247. In addition, two rare phenotypes were observed which appear to be due to a rare allele tentatively identified as Gc2C2.

The distribution of Gc subtypes among the mongoloid populations.

The polymorphism of Gc (group-specific components) has been investigated for a series of 3,160 individual samples from 11 Mongoloid populations in Asia and North and South America by isoelectric focusing on polyacrylamide gels. The samples fall into six Gc phenotypes which can be explained by the three common alleles, Gc1F, Gc1S, and Gc2, together with several variant phenotypes explained as the heterozygotes for the three common alleles. The distribution of Gc1F suballele appears to be considerably different from population to population among Mongoloids, ranging from 0.105 (Machiguenga Indians, Peru) to 0.609 (Kadazan, Borneo). A clear geographic cline from Southeast Asia into South America in Gc1F allele was observed in the populations. In general, Gc1F allele frequencies are lower in European populations and higher in African populations. The range of variability in the Gc1F values observed among the Asiatic populations is between the Africans and the Europeans.

Distribution of Gc-subtypes in Western Germany (Düsseldorf region).

Gc-subtypes were determined by isoelectric focusing and immunofixation on samples from 1157 unrelated individuals. The frequency of the three genes was found to be Gc1S 0.5476, Gc1F 0.1561, Gc2 0.2963. A rare allele, GcVI, was observed.

Group-specific component (Gc) polymorphism in Japanese: An analysis by isoelectric focusing on polyacrylamide gels

Using the immunofixation isoelectric focusing method, Gc subtypes were examined in the samples with the Gc J phenotypes previously determined by immunoelectrophoresis, and it was found that theGc Js are subdivided into 4 different alleles. A population study in sera from 1,041 individuals confirmed the presence of the 4 variant alleles with the frequencies between 0.020 for the highest allele and 0.001 for the lowest one. The distribution of Gc subtypes in a Japanese population and a pedigree study from 18 families with the propositus of the variant are presented along with a description of the 2 other variants observed in the course of this study.

The distribution of the group-specific component (Gc) subtypes in Japanese.

The distribution of Gc subtypes in a sample from 310 unrelated healthy Japanese living in Tokyo was examined by a slab polyacrylamide gel isoelectrofocusing followed by immunofixation. At least 9 phenotypes were distinguished which can be ascribed to four alleles:Gc1F,Gc1S,Gc2 andGcJ. The allele frequencies were 0.4656, 0.2590, 0.2574 and 0.0180, respectively. It was confirmed thatGcJ has a polymorphic frequency in Japanese. Furthermore, two unusual phenotypes were encountered, one with a variant Gc 1 and the other with a variant Gc 2 protein, indicating the occurrence in Japanese of two further Gc alleles.

Genetic studies on the Gc subtypes

Gc subtypes were determined by immunofixation isoelectric focusing. In a family study involving 93 families with a total of 176 children, a three-allele model with six genotypes was confirmed. The distribution of Gc subtypes was studied in three populations from Europe and in a sample of Druzes from Northern Israel. Three new variant Gc types were observed.