The Post Biomethanated Distillery Spentwash (PBDSW) is effective organic liquid manure derived from sugar industry waste materials. Spentwash contain high amount of nutrients like Nitrogen, Phosphorus, Potassium, Calcium and Sulfur. In addition, it contains sufficient amount of micronutrients such as Iron, Zinc, Copper, Manganese, Boron and Molybdenum. The spentwash application on land is beneficial to control the water pollution and agricultural production. The experiment was performed with different doses of Post Biomethanated Distillery Spentwash (PBDSW) as a source of nutrients in various proportions with inorganic fertilizer using pearl millet as the test crop. The results of the experiment showed that the application of PBDSW at the rate of 100 KL ha-1 in combination with NPK recorded higher ear head, grain and stover yield as compared to other substitution level, split application and control.