Distention of the proximal jejunum in dogs anesthetized with chloralose and urethane produced an increase in gastric secretion from the intact stomach. In dogs equipped with pancreatic cannulas and given a constant background infusion of commercial secretin, similar distention of the jejunum caused increased protein output in the pancreatic secretion. When the blood supply of the jejunum and ileum were isolated and perfused extracorporeally (the autonomic nerves remaining intact as verified by electrical stimulation), distention of the jejunum produced no increase in gastric acid or pancreatic protein output. In 6 dogs, upon discontinuing the extracorporeal perfusion, the blood supply was successfully reconstituted. Distention of the jejunum again produced an increase in gastric acid or an increase in pancreatic protein output. Ileal absorption of glucose against a concentration gradient remained unaltered throughout. Histology of the bowel was normal. It is concluded that long nervous reflex arcs did not play a significant role in eliciting the gastric or pancreatic response when the small intestine was stimulated by distention under chloralose-urethane anesthesia. Such effects were humoral and were compatible with those of gastrin or cholecystokinin-pancreozymin .
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