Dissolution Model Research Articles

Simulation Analysis and Process Evaluation of Cooling Hole Forming Precision in Mask Assisted Electrochemical Machining Based on GH4169.

Good heat dissipation performance of aero-engine an effectively improve the service performance and service life of aero-engine. Therefore, this paper studies the machining method of cooling holes of high-temperature existent material GH 4169 for aero-engine innovatively puts forward the mask electrochemical machining method of cooling holes and explores the entrance morphology and taper formation law of the hole structure of high-temperature resistant material GH 4169. The mathematical model of anode dissolution of cooling holes in ECM is established, and the influence of voltage and electrolyte flow rate on cooling holes in ECM is analyzed. Compared with the mask-less electrochemical machining, the inlet radius of cooling holes in mask electrochemical machining is reduced by about 16.0% and the taper is reduced by 52.8% under the same machining parameters, which indicates that the electrochemical machining efficiency of mask is higher and the machining accuracy is better. Experiments show that the diameter of the mask structure improves the accuracy of the inlet profile of the cooling hole in the ECM. The diameter of the mask increases from 2 mm to 2.8 mm, and the inlet radius of the cooling hole increased from 1.257 mm to 1.451 mm When the diameter of the mask is 2.2 mm, the taper of the cooling hole decreased by 53.4%. The improvement effect is best, and the thickness of the mask has little influence on the forming accuracy of the cooling hole.

Development of In Vitro Dissolution Testing Methods to Simulate Fed Conditions for Immediate Release Solid Oral Dosage Forms.

In vitro dissolution testing is widely used to mimic and predict in vivo performance of oral drug products in the gastrointestinal (GI) tract. This literature review assesses the current in vitro dissolution methodologies being employed to simulate and predict in vivo drug dissolution under fasted and fed conditions, with emphasis on immediate release (IR) solid oral dosage forms. Notable human GI physiological conditions under fasted and fed states have been reviewed and summarized. Literature results showed that dissolution media, mechanical forces, and transit times are key dissolution test parameters for simulating specific postprandial conditions. A number of biorelevant systems, including the fed stomach model (FSM), GastroDuo device, dynamic gastric model (DGM), simulated gastrointestinal tract models (TIM), and the human gastric simulator (HGS), have been developed to mimic the postprandial state of the stomach. While these models have assisted in expanding physiological relevance of in vitro dissolution tests, in general, these models lack the ability to fully replicate physiological conditions/processes. Furthermore, the translatability of in vitro data to an in vivo system remains challenging. Additionally, physiologically based pharmacokinetic (PBPK) modeling has been employed to evaluate the effect of food on drug bioavailability and bioequivalence. Here, we assess the current status of in vitro dissolution methodologies and absorption PBPK modeling approaches to identify knowledge gaps and facilitate further development of in vitro dissolution methods that factor in fasted and fed states. Prediction of in vivo drug performance under fasted and fed conditions via in vitro dissolution testing and modeling may potentially help efforts in harmonizing global regulatory recommendations regarding in vivo fasted and fed bioequivalence studies for solid oral IR products.

Frequency Dependent Silica Dissolution Rate Enhancement under Oscillating Pressure via an Electrochemical Pressure Solution-like, Surface Resonance Mechanism.

From atomic force microscopy (AFM) experiments, we report a new phenomenon in which the dissolution rate of fused silica is enhanced by more than 5 orders of magnitude by simply pressing a second, dissimilar surface against it and oscillating the contact pressure at low kHz frequencies in deionized water. The silica dissolution rate enhancement was found to exhibit a strong dependence on the pressure oscillation frequency consistent with a resonance effect. This harmonic enhancement of the silica dissolution rate was only observed at asymmetric material interfaces (e.g., diamond on silica) with no evidence of dissolution rate enhancement observed at symmetric material interfaces (i.e., silica on silica) within the experimental time scales. The apparent requirement for interface dissimilarity, the results of analogous experiments performed in anhydrous dodecane, and the observation that the silica "dissolution pits" continue to grow in size under contact stresses well below the silica yield stress refute a mechanical deformation or chemo-mechanical origin to the observed phenomenon. Instead, the silica dissolution rate enhancement exhibits characteristics consistent with a previously described 'electrochemical pressure solution' mechanism, albeit, with greatly amplified kinetics. Using a framework of electrochemical pressure solution, an electrochemical model of mineral dissolution, and a recently proposed "surface resonance" theory, we present an electro-chemo-mechanical mechanism that explains how oscillating the contact pressure between dissimilar surfaces in water can amplify surface dissolution rates by many orders of magnitude. This reaction rate enhancement mechanism has implications not only for dissolution but also for potentially other reactions occurring at the solid-liquid interface, e.g. catalysis.

Reunderstanding the Reaction Mechanism of Aqueous Zn-Mn Batteries with Sulfate Electrolytes: Role of the Zinc Sulfate Hydroxide.

Rechargeable aqueous Zn-Mn batteries have garnered extensive attention for next-generation high-safety energy storage. However, the charge-storage chemistry of Zn-Mn batteries remains controversial. Prevailing mechanisms include conversion reaction and cation (de)intercalation in mild acid or neutral electrolytes, and a MnO2 /Mn2+ dissolution-deposition reaction in strong acidic electrolytes. Herein, a Zn4 SO4 ·(OH)6 ·xH2 O (ZSH)-assisted deposition-dissolution model is proposed to elucidate the reaction mechanism and capacity origin in Zn-Mn batteries based on mild acidic sulfate electrolytes. In this new model, the reversible capacity originates from a reversible conversion reaction between ZSH and Znx MnO(OH)2 nanosheets in which the MnO2 initiates the formation of ZSH but contributes negligibly to the apparent capacity. The role of ZSH in this new model is confirmed by a series of operando characterizations and by constructing Zn batteries using other cathode materials (including ZSH, ZnO, MgO, and CaO). This research may refresh the understanding of the most promising Zn-Mn batteries and guide the design of high-capacity aqueous Zn batteries.

New radiolysis-driven matrix dissolution operational model based on stationary UO2 voltametric experiments

In the framework of research on direct deep disposal of spent nuclear fuel, a new α radiolysis-driven matrix dissolution model is proposed. This model is based on an experimental stationary voltametric curve established using a UO2 rotating disk electrode in a neutral pH non-complexing solution under reducing conditions. Kinetic and chemical speciation calculations give access to the equilibrium redox potential of a simulated Callovo-Oxfordian pore water solution containing α-radiolysis products, which is used in the experimentally obtained current-potential relationship to estimate the oxidative dissolution rate. Comparison of model results with literature data show good agreement with previously established α−activity threshold values.

Open source anaerobic and temperature-controlled in vitro model enabling real-time release studies with live bacteria

In vitro release and dissolution models are widely used in the development phases of oral drug delivery systems to measure how an active pharmaceutical ingredient (API) is released from a dosage form. However, additional requirements for these models arise when evaluating probiotic dosage forms since they are often sensitive to temperature and oxygen levels. As a solution to this, we propose a custom-designed anaerobic in vitro release setup, made mainly by 3D printing and laser cutting, to function together with state-of-the-art pharmaceutical dissolution equipment – in this case, a microDISS Profiler™. The in vitro release model makes it possible to study the release rate of oxygen-sensitive probiotics in simulated intestinal conditions, while ensuring their survival due to the anaerobic conditions. This has not been possible so far since the available in vitro dissolution models have not been compatible with anaerobic conditions. With two different case studies, the developed model combined with a microDISS Profiler™ has proven capable of measuring the release of a probiotic and a small-molecule API from microdevices for oral drug delivery. Further, the model facilitated the survival of anaerobic bacteria present in the release medium.

Biomedical applications of L-alanine produced by Pediococcus acidilactici BD16 (alaD+).

L-alanine possesses extensive physiological functionality and tremendous pharmacological significance, therefore could be considered as potential ingredient for food, pharmaceutical, and personal care products. However, therapeutic properties of L-alanine still need to be addressed in detail to further strengthen its utilization as a viable ingredient for developing natural therapeutics with minimum side effects. Thus, the present study was aimed to explore the anticipated therapeutic potential of L-alanine, produced microbially using a lactic acid bacterial strain Pediococcus acidilactici BD16 (alaD+) expressing L-alanine dehydrogenase enzyme. The anticipated therapeutic potential of L-alanine was assessed in terms of anti-proliferative, anti-bacterial, and anti-urolithiatic properties. Anti-bacterial assays revealed that L-alanine successfully inhibited growth and in vitro proliferation of important human pathogens including Enterococcus faecalis, Escherichia coli, Klebsiella pneumonia, Staphylococcus aureus, Streptococcus mutans, and Vibrio cholerae in a concentration-dependent manner. Current investigation has also revealed its significant anti-proliferative potential against human lung adenocarcinoma (A549; IC50 7.32μM) and mammary gland adenocarcinoma (MCF-7; IC50 8.81μM) cells. The anti-urolithiatic potential of L-alanine was augmented over three different phases, viz., nucleation inhibition, aggregation inhibition, and oxalate depletion. Further, an in vitro cell culture-based kidney stone dissolution model using HEK293-T cells was also established to further strengthen its anti-urolithiatic potential. This is probably the first in vitro cell culture-based model which experimentally validates the immense therapeutic efficacy of L-alanine in treating urolithiasis disease. KEY POINTS: • Assessment of therapeutic potential of L-alanine produced by LAB. • L-alanine exhibited significant anti-proliferative and anti-bacterial activities. • L-alanine as potential anti-urolithiatic agent.

Dissolution kinetics and solubility of copper oxide nanoparticles as affected by soil properties and aging time.

Nano copper oxide (CuO NP) was added to eight soils to study the effect of aging time of copper on the concentration of diethylenetriaminepentaacetic acid (DTPA)-extracted copper (DTPA-Cu), with bulk copper oxide (CuO BP) and copper nitrate [Cu(NO3)2] used for comparison. Moreover, the effect of soil properties on the dissolution of CuO NP was studied. A dissolution model was used to quantitatively describe the dissolution kinetics of CuO NPs in different soils. The results showed that the concentration of DTPA-Cu decreased with increasing aging time in soils spiked with Cu(NO3)2, while the concentration increased to varying degrees in soils spiked with CuO NPs or CuO BPs. In acidic soils, the equilibrium concentrations of DTPA-Cu were 93.3-98.7mg·kg-1 for CuO NP treatments, 65.5-94.3mg·kg-1 for CuO BP treatments, and 81.4-90.0mg·kg-1 for Cu(NO3)2 treatments, which were greater than those in alkaline soils (43.4-56.9mg·kg-1, 6.26-8.61mg·kg-1, and 73.9-80.0mg·kg-1, respectively). In acidic soils, DTPA-Cu equilibrium concentration ranked the different forms of copper treatments as CuO NPs > Cu(NO3)2 > CuO BPs, while in alkaline soils, the order was Cu(NO3)2 > CuO NPs > CuO BPs. The dissolution rate constants and solubility of CuO NPs were 0.33-6.42 and 37.1-100.1mg·kg-1, respectively. Pearson correlation analysis indicated that the dissolution parameters of CuO NPs were negatively correlated with soil pH and positively correlated with the contents of organic matter, clay, iron oxides, and aluminum oxides. Further, the dissolution rate constant and solubility of CuO NPs could be well predicted by soil pH and the content of free or amorphous aluminum. Our study identified the main factors controlling the dissolution of CuO NPs in farmland soils and highlighted the higher availability of CuO NPs in acidic soils.

Genetic mechanism and grading assessment of the glutenite reservoirs in the Eocene Shahejie Formation, Chezhen Sag, Bohai Bay Basin

Abundant oil potential has been confirmed in the Eocene Shahejie Formation (Es) in the Chezhen Sag, but the genetic mechanism of its reservoir has not been fully understood. Based on core observation, thin-section identification, scanning electron microscopy (SEM), X-ray diffraction, and formation pressure measurement, the factors controlling the quality of glutenite reservoirs in the Shahejie Formation in the Chezhen Sag were revealed. The petrophysical structure, depositional facies, diagenesis, and formation overpressure jointly control the development and evolution of glutenite reservoirs. Reservoirs with high composition maturity exhibit better physical properties. Depositional facies control the development of high- and poor-quality reservoirs but have little influence on the physical properties of medium-quality reservoirs. Compaction is the main factor for reducing reservoir porosity during burial, and the cementation of carbonate and clay minerals affects the reservoir quality to some extent. Each secondary structural zone shows different dissolution models. The reservoirs in the steep slope zone are in a closed system with weak dissolution, hardly contributing to improving the reservoir porosity. The dissolution of reservoirs in the depression zone has been enhanced; however, the migration of dissolution products is restricted because of the closed reservoirs, causing the redistribution of pore space and limited contribution to improving the physical properties. The reservoir in the gentle slope zone is in an open system with a shallow buried depth, and severe dissolution can effectively improve the reservoir's physical properties. A grading assessment scheme is proposed based on the depositional facies, diagenesis, and formation overpressure, and favorable exploration zones are predicted. The western part of the gentle slope zone in the upper part of the Es4 member and the eastern part of the steep slope zone in the lower part of the Es3 member of the Chezhen Sag are the principal target areas for exploration.

The genesis and evolution of karstic conduit systems in the Chalk

Abstract The Upper Cretaceous Chalk Group is renowned as a major aquifer, but the development of secondary porosity due to karstic conduits is poorly understood. Hydrogeological data and evidence from boreholes, sections, and tracer tests indicate that dissolutional conduits occur throughout the Chalk aquifer. Here, we assess the evidence for Chalk karst, and combine it with theoretical models of dissolution and cave formation to produce a conceptual model for the development of karstic conduits. Dissolution due to the mixing of saturated waters of contrasting chemistry along key lithostratigraphical inception horizons form extensive but isolated conduit networks. These form a significant proportion of the secondary porosity and enhance permeability. They prime the aquifer for the development of more integrated conduit networks formed by focused recharge of unsaturated surface derived water. However, the porous, well-fractured nature of the Chalk means that the time needed to form large integrated cave systems is often longer than timescales of landscape change. Continued landscape evolution and water table lowering halts conduit development before they can enlarge into cave systems except where geological and geomorphological settings are favourable. Groundwater models need to consider the formation of secondary karst permeability as this has a major influence on groundwater flow.

Computational Modeling of Drug Dissolution in the Human Stomach.

A computational model of drug dissolution in the human stomach is developed to investigate the interaction between gastric flow and orally administrated drug in the form of a solid tablet. The stomach model is derived from the anatomical imaging data and the motion and dissolution of the drug in the stomach are modeled via fluid-structure interaction combined with mass transport simulations. The effects of gastric motility and the associated fluid dynamics on the dissolution characteristics are investigated. Two different pill densities are considered to study the effects of the gastric flow as well as the gravitational force on the motion of the pill. The average mass transfer coefficient and the spatial distributions of the dissolved drug concentration are analyzed in detail. The results show that the retropulsive jet and recirculating flow in the antrum generated by the antral contraction wave play an important role in the motion of the pill as well as the transport and mixing of the dissolved drug concentration. It is also found that the gastric flow can increase the dissolution mass flux, especially when there is substantial relative motion between the gastric flow and the pill.

Development and application of computationally efficient 3D model of CO2 convective dissolution in saline aquifers.

Development and application of computationally efficient 3D model of CO2 convective dissolution in saline aquifers.

A Model of Pore Dissolution at Grain Boundaries during Annealing of an Ultra-Fine-Grained Aluminum Alloy

A Model of Pore Dissolution at Grain Boundaries during Annealing of an Ultra-Fine-Grained Aluminum Alloy

Dissolution kinetics of citrate coated CoFe2O4nanoparticles in soil solution

Citrate-coated CoFe2O4nanoparticles release iron fertilizers in artificial root exudates following a Korsmeyer–Peppas dissolution model.

EVALUATION OF IN-VITRO LITHOLYTIC ACTIVITY OF PLANT BOUGAINVILLEA SPECTABILIS

The aim of present investigation is to evaluate the in-vitro anti urolithiatic activity of the leaves of the plant Bougainvillea spectabilis (Willd.). Ethanolic and aqueous extracts of Bougainvillea spectabilis fresh leaves were prepared. Homogenous precipitation methods were used to prepare artificial stones of calcium oxalate. Semi-permeable membrane of eggs was used as dissolution bags. Different in-vitro anti urolithiatic studies were used such as method of mineralization and titrimetric method to evaluate the inhibition and dissolution of stone crystal using standard drug Cystone. In inhibition as well as dissolution models, the ethanolic extract of Bougainvillea spectabilis has shown better capability to dissolve calcium oxalate. Cystone exhibited strongly inhibitory action in both, the method of mineralization and titrimetric assay. Thus, it was concluded that the ethanolic extract of Bougainvillea spectabilis exhibited inhibitory action in both of the methods to a significant level and the bioactive natural products present in leaf extracts of Bougainvillea spectabilis can be used in the development of new pharmaceuticals that enhances therapeutic use in renal calculi.

On the dissolution of a borosilicate glass with the use of isotopic tracing – Insights into the mechanism for the long-term dissolution rate

An understanding of the mechanisms responsible for controlling the long-term corrosion rate of nuclear waste glass is paramount if reliable glass dissolution models are to be used to calculate the controlled release of radionuclides from nuclear waste glass under geologic disposal conditions. Understanding the mechanism that controls silicate glass dissolution rates is also important for natural glasses to understand the role from the dissolution of these glasses has on the composition of natural aquatic systems. Two general mechanisms appear to be responsible for the elemental release from glass to the surrounding biosphere – ion exchange (release principally of alkalis) and matrix dissolution (release of the structural components of the glass). Key unknowns related to these mechanisms are the impact of surface layers on the altered glass and how these layers participate in corrosion. To better understand the impact of these layers on the long-term glass corrosion rate, we made two glasses of the same elemental composition, but with selected elements enriched in specific isotopes for B (11B), Li (6Li), and Si (29Si). We reacted these glasses for 1 y then the solutions from each were exchanged and the chemistry of the solutions and the solids were followed for another 2 y (a total of 3 y). This allowed us to follow changes in the glasses with respect to these elements and how these elements were transported through the alteration layers with time and, for at least one element, into the glass and to deconvolute some competing kinetic steps, such as matrix dissolution and ion exchange. Results from these experiments demonstrate that the release behavior of different elements is strongly dependent on their structural role in the glass (e.g. network formers and modifiers), but, more importantly, the role of water transport and subsequent ion exchange has in the long-term dissolution of the glass studied here. In this article, we highlight the behavior of four elements: lithium, sodium, silicon, and boron. Lithium and sodium, network modifying elements, have similar chemistries. The behavior of Li could be tracked in more detail by following both 6Li and 7Li; Li penetrates through the gel layer in both directions without hinderance and is released from the glass deeper than Na. Silicon, a network forming element, reacts with the silica-rich alteration layer. Boron, a network forming element, does not accumulate in the gel or the pristine glass and has a very sharp elemental profile between the pristine glass and alteration layer. Boron, lithium, and sodium elemental profiles suggest that there is little if any transport control within the alteration layer. These results are similar to those found for basalt glass. However, the correlation between the Li and Na profiles and that of a water species suggest that the limiting release is not controlled by the formation of the gel but rather is a steady state between the diffusion of a water species and matrix dissolution that results in a low release rate for alkali and this provides a steady driving force for the long-term dissolution of glass.

Mathematical modeling of selective dissolution of AISI 304 steel in circulating chloride-containing waters during operation of heat exchangers

Purpose. Investigation of the effect of chloride-containing medium, chemical composition and structural heterogeneity of AiSi304 steel on selective dissolution of metals ΔCr, ΔNi and ΔFe from stable pits.
 Research methods. X-ray structural analysis, optical microscopy, energy dispersive microanalysis, analysis of the developed linear regression mathematical models of the second order for corrosion losses of metals from pits.
 Results. Based on the analysis of the developed linear regression mathematical models of the second order for corrosion losses of metals from pits, it was found that ΔFe from pits on the surface of AISI 304 steel in model circulating water with pH = 4...8 and chloride concentration of 300 and 600 mg / l decrease with an increase in it. the amount of oxides (1.98...3.95 microns), the average diameter of the austenite grain and increase when the average distance between the oxides and the volume of b- ferite in steel increases. It is proved that ΔNi from pits decreases with an increase in the amount of oxides in steel (1.98...3.95 μm), the volume of b- ferite and a decrease in the average diameter of austenite grain.
 It was determined that ΔCr of steel from pits mainly depends on the concentration of chlorides in the model circulating water, the amount of oxides (1.98 ... 3.95 μm), the average diameter of the austetin grain and the volume of b-ferite. It is hypothesized that this is due to the intensity of adsorption of chlorine ions on imperfections in the structure of AISI304 steel near these oxides at the intersection with the grain boundaries of austenite, where pits nucleate and grow.
 Scientific novelty. It was established for the first time that the coefficient of selective dissolution of Cr from pits on the surface of AISI 304 (ZCr ) steel in the circulating waters of the river decreases with an increase in the volume of b-ferite in the steel, the average diameter of austenite grain and a decrease in the amount of oxides. This can facilitate the transition of metastable pits to stable ones. Moreover, this process is autocatalytic; therefore, it does not depend on the parameters of the model circulating water.
 Statement of tasks. Based on the established features of selective dissolution of ΔCr, ΔNi and ΔFe from pits on the surface of AISI304 steel, to study the effect of its plastic defermation on pitting resistance in chloride-containing model circulating waters.
 Practical value. The developed mathematical models are used to assess the pitting resistance of AISI304 steel in model circulating waters, depending on its parameters and the environment where heat exchangers made of this steel operate.

Characteristic evaluation of the pseudo-polymorphism of amorphous atorvastatin calcium hydrates by terahertz spectroscopy

In order to scientifically elucidate the difference in the dissolution characteristics of crystalline atorvastatin calcium (ATCH) and the amorphous ATC solids (ATC30 and ATC120) obtained by the grinding for 30 and 120 min, X-ray powder diffractometry (XRD), infrared (IR) spectroscopy, near-infrared (NIR) spectroscopy, terahertz (THz) spectroscopy and thermal analysis were measured, and compared with the result of dissolution kinetics analysis. ATCH showed characteristic crystalline XRD pattern, but ATC30 and ATC120 showed no XRD peak profiles, meaning that those completely transformed into the amorphous solids. ATCH, ATC30 and ATC120 showed also individual characteristic IR and NIR spectra, respectively. ATCH contained 3 mol of crystal water, but ATC30 and ATC120 contained weakly binding adsorbed water in the amorphous solids, respectively. The result of the dissolution kinetic analysis based on the dissolution model including the phase transition showed that the dissolution behaviors of ATCH, ATC30 and ATC120 were significantly different, respectively, reflecting their intermolecular interaction in the solids. THz was able to indicate a difference between the chemical structure of amorphous solids ATC30 and ATC120, which were not able to discriminate by the XRD. • Crystalline atorvastatin Ca was transformed into amorphous solid by the grinding. • Amorphous grinding for 30 min had lower solubility than amorphous for 120 min. • X-ray diffraction profile of amorphous for 30 min was same as that for 120 min. • Terahertz spectrum of amorphous for 30 min was different from that for 120 min. • Terahertz spectrum of amorphous for 30 min was different from that for 120 min.

A combined mechanism (the open pores-cake dissolution) model for describing the trans-membrane pressure (Pb(t)) reduction in the backwash process at a constant flow rate

Accurate prediction of the trans-membrane pressure (Pb(t)) reduction in the backwash process at a constant flow rate has a great significance for the industrial backwash process. In this paper, a combined mechanism (the open pores-cake dissolution) model was established to predict the variation of Pb(t) in the backwash process at a constant flow rate for 0.1 µm polyacrylonitrile (PAN) membrane fouled with activated sludge suspension. Meanwhile, the proposed model was validated by using other foulants (yeast, bovine serum albumin and sodium alginate), membranes (0.1 µm polyethersulfone (PES) and polyvinylidene fluoride (PVDF) membranes) and at different fouling conditions (filtrate flow rate, mixed liquor suspended solid (MLSS) concentration and cross-flow velocity). The results showed that the model predictions were in good agreements with experimental data (R2>0.986, relative error σ¯ <3.28%). Moreover, according to the variation of Pb(t), the backwash process can be divided into three stages: (i) Pb(t) decreased rapidly (the open pores-cake dissolution) before ti (the first transition point); (ii) Pb(t) decreased slowly (cake dissolution) in the range of ti to tj (the second transition point); (iii) Pb(t) is almost constant (without the open pores and cake dissolution) after tj. Thus, the proposed model would provide a theoretical basis for achieving the goal of high-efficient and energy-saving in the backwash process at a constant flow rate.

Drastic Modulation of Molecular Packing and Intrinsic Dissolution Rates by Meniscus-Guided Coating of Extremely Confined Pharmaceutical Thin Films.

Nanosizing has emerged as one of the most effective formulation strategies for enhancement of dissolution properties of active pharmaceutical ingredients (APIs). In addition to enhancing the specific area of the dissolving solids, nanosizing can also capture and stabilize the metastable form of the API, which can further enhance the solubility by drastic modulation of surface energies. Herein, we employ meniscus-guided coating to fabricate nanothin films of three APIs that show anticancer properties and are poorly soluble:10-HCPT, SN-38, and amonafide. By modulating the coating speed, we systematically deposited the APIs in films ranging from ∼200 nm thickness to extreme confinement of ∼10 nm (<10 molecular layers). In all three APIs, we observe a general order-to-disorder transition with semicrystalline (10-HCPT and amonafide) or amorphous (SN-38) form of API solids trapped in thin films when the thickness decreases below a critical value of ∼25-30 nm. The existence of a critical thickness highlights the importance of nanoconfinement in tuning molecular packing. In the case of 10-HCPT, we demonstrate that the disordered form of the API occurs largely due to lack of incorporation of water molecules in thinner films below the critical thickness, thereby disrupting the three-dimensional hydrogen-bonded network held by water molecules. We further developed a dissolution model that predicts variation of the intrinsic dissolution rate (IDR) with API film thickness, which also closely matched with experimental results. We achieved drastic improvement in the IDR of ∼240% in 10-HCPT by decreasing film thickness alone. Further leveraging the order-to-disorder transition led to 2570% modulation of the IDR for amonafide. Our work demonstrates, for the first time, opportunities to largely modulate API dissolution by precisely controlling the dimensionality of thin films.