This study aimed at increasing the dry reforming reaction of propane with CO2 by using trimetallic oxide catalyst based on the reactive support of ZrO2/TiO2. Multiple basic (Mg, Be and Ba) and transition metal oxide (Cu, Fe) and Al were impregnated separately into 5%ZrO2/TiO2 catalyst support and characterized by XRD, BET, CO2-TPD and NH3-TPD. The catalysts showed an increase in the number of basic surface sites, with the trimetallic catalysts exhibiting more than 2.2–9.7 times the original number of basic sites of the Zr/Ti oxide support. In order to maximize greenhouse gas conversion, selected ratios of CO2/propane were correlated to increase syngas (CO and H2) product and promote more CO2 reactions via surface intermediates from CC bond dissociation of propane. Utilizing trimetallic catalysts enabled a three folds increase of CO yield compared to the reactive support used in the study. Although the selectivity towards H2 and CO increase with trimetallic catalysts, 2%Fe/5%ZrO2/TiO2 and 2%Be/5%ZrO2/TiO2 exhibited the highest propane dry reforming conversions (84–97%) with yields of H2 (35–51%) and CO (60–68%), respectively. The study demonstrated that each trimetallic oxide catalyst consumed CO2 differently, promoting distinct CC bond breaking patterns of propane over the catalyst surface.