The article presents the results of assessing the effect of the welding speed and the displacement of the electron beam relative to the joint on the mechanical heterogeneity of the weld metal of dissimilar welded joints of EP517 (Fe12Cr2NiMoWVNb) steel and 36NKhTYu (Fe36Ni12Cr3TiAl) alloy. Aging curves are plotted for the weld metal of welded joints made at electron beam welding (EBW) speeds of 30 m/h and 120 m/h, as well as for the weld metal of the welded joint made at a speed of 30 m/h with various electron beam displacements. An assessment of the change in the mechanical heterogeneity of the weld metal was carried out by the change in the standard deviation of the hardness values, and metallographic studies were also carried out. It was found that a decrease in the EBW speed leads to a decrease in the standard deviation of the results of measuring the hardness of the weld metal after aging from 45 to 14 HV5 or from 18% to 6%. It was also found that an increase in the displacement of the electron beam to alloy 36NKhTYu (Fe36Ni12Cr3TiAl) to 60% leads to an increase in the hardness of the weld metal from 225 to 305 HV5 (by 35%).