Barriers To Dissemination Research Articles

User-Centered Framework for Implementation of Technology (UFIT): Development of an Integrated Framework for Designing Clinical Decision Support Tools Packaged With Tailored Implementation Strategies.

Electronic health record-based clinical decision support (CDS) tools can facilitate the adoption of evidence into practice. Yet, the impact of CDS beyond single-site implementation is often limited by dissemination and implementation barriers related to site- and user-specific variation in workflows and behaviors. The translation of evidence-based CDS from initial development to implementation in heterogeneous environments requires a framework that assures careful balancing of fidelity to core functional elements with adaptations to ensure compatibility with new contexts. This study aims to develop and apply a framework to guide tailoring and implementing CDS across diverse clinical settings. In preparation for a multisite trial implementing CDS for pediatric overweight or obesity in primary care, we developed the User-Centered Framework for Implementation of Technology (UFIT), a framework that integrates principles from user-centered design (UCD), human factors/ergonomics theories, and implementation science to guide both CDS adaptation and tailoring of related implementation strategies. Our transdisciplinary study team conducted semistructured interviews with pediatric primary care clinicians and a diverse group of stakeholders from 3 health systems in the northeastern, midwestern, and southeastern United States to inform and apply the framework for our formative evaluation. We conducted 41 qualitative interviews with primary care clinicians (n=21) and other stakeholders (n=20). Our workflow analysis found 3 primary ways in which clinicians interact with the electronic health record during primary care well-child visits identifying opportunities for decision support. Additionally, we identified differences in practice patterns across contexts necessitating a multiprong design approach to support a variety of workflows, user needs, preferences, and implementation strategies. UFIT integrates theories and guidance from UCD, human factors/ergonomics, and implementation science to promote fit with local contexts for optimal outcomes. The components of UFIT were used to guide the development of Improving Pediatric Obesity Practice Using Prompts, an integrated package comprising CDS for obesity or overweight treatment with tailored implementation strategies. ClinicalTrials.gov NCT05627011; https://clinicaltrials.gov/study/NCT05627011.

Vector competence of Swedish Culex pipiens mosquitoes for Japanese encephalitis virus

BackgroundJapanese encephalitis virus (JEV) is an emerging mosquito-borne Orthoflavivirus that poses a significant public health risk in many temperate and tropical regions in Asia. Since the climate in some endemic countries is similar to temperate climates observed in Europe, understanding the role of specific mosquito species in the transmission of JEV is essential for predicting and effectively controlling the potential for the introduction and establishment of JEV in Europe.MethodsThis study aimed to investigate the vector competence of colonized Culex pipiens biotype molestus mosquitoes for JEV. The mosquitoes were initially collected from the field in southern Sweden. The mosquitoes were offered a blood meal containing the Nakayama strain of JEV (genotype III), and infection rates, dissemination rates, and transmission rates were evaluated at 14, 21, and 28 days post-feeding.ResultsThe study revealed that colonized Swedish Cx. pipiens are susceptible to JEV infection, with a stable infection rate of around 10% at all timepoints. However, the virus was only detected in the legs of one mosquito at 21 days post-feeding, and no mosquito saliva contained JEV.Conclusions Overall, this research shows that Swedish Cx. pipiens can become infected with JEV, and emphasizes the importance of further understanding of the thresholds and barriers for JEV dissemination in mosquitoes.Graphical

Formal support and service needs of family caregivers of adults with intellectual and/or developmental disabilities in India.

Despite the enactment of disability laws/policies in India, research shows that caregivers of adults with intellectual and/or developmental disabilities experience inadequate formal supports/services due to dissemination barriers and lack of awareness about them. To address discrepancy between caregivers' support needs and the professionals' understanding of their needs, the study proposed to conduct a caregiver needs assessment so that culturally-tailored programs are developed. A strengths-based mixed methods needs assessment was conducted with a convenience sample of 100 caregivers in Hyderabad, India. One hundred caregivers completed the survey and 15 caregivers participated in semi-structured interviews. Caregivers needed more and improved formal supports/services, particularly from the government. Caregivers faced systemic and attitudinal barriers, and personal impediments to accessing them. Needs differed by care recipients' intellectual disability level, gender, and intellectual disability related conditions. Researchers, service providers and policymakers need to adopt innovative strategies to improve formal supports/services access.

Exploring public health researchers' approaches, barriers, and needs regarding dissemination: A mixed-methods exploration.

Although there is growing attention to research translation, dissemination practices remain underdeveloped. This study aimed to gain insights into the dissemination approaches, barriers for dissemination, and needs for dissemination support of public health researchers of the Amsterdam Public Health (APH) research institute. A concurrent mixed-methods design was used, collecting quantitative and qualitative data through a survey and qualitative data from interviews. Researchers of the Health Behaviors and Chronic Diseases (HBCD) research line of APH were approached via email with a link to an online survey. For the interviews, we aimed to balance researchers in terms of career phase and position. Data were analyzed through descriptive statistics and thematic content analysis. HBCD researchers primarily rely on traditional approaches for dissemination, e.g. academic journals (93%), conferences (93%), and reports to funders (71%). Social media (67%) was also frequently mentioned. Dissemination is often prioritized late due to time constraints and competing priorities. Researchers mentioned a lack of time, money, knowledge, and skills but also limited awareness of available support as barriers. A need for more resources, education, and a shift in mindset was expressed, suggesting a comprehensive inspiring platform and stronger in-house connections as solutions. HBCD researchers emphasized the importance of dedicated time and budget for dissemination, as well as other forms of institutional support. Overall, there is a need for a shift in mindset, more educational initiatives, greater integration of dissemination into researchers' roles, the establishment of a comprehensive inspiring platform, and stronger in-house connections to support dissemination efforts.

Are public health researchers designing for dissemination? Findings from a national survey in China

BackgroundResearch findings are not always disseminated in ways preferred by audiences, and research dissemination is not always considered a priority by researchers. While designing for dissemination (D4D) provides an active process to facilitate effective dissemination, use of these practices in China is largely unknown. We aimed to describe the designing for dissemination activities and practices among public health researchers in China.MethodsIn January 2022, we conducted a cross-sectional survey in 61 sub-committees of four national academic societies which include a wide range of health disciplines. The sample mainly involved researchers at universities or research institutions, the Centers for Disease Control and Prevention at national or regional levels, and hospitals. Participants completed a 42-item online questionnaire. Respondent characteristics, dissemination routes, dissemination barriers, organizational support, and personal practice of D4D were examined with descriptive analyses.ResultsOf 956 respondents, 737 were researchers. Among these researchers, 58.1% had disseminated their research findings. Although there were some variation in the commonly used routes among different groups, academic journals (82.2%) and academic conferences (73.4%) were the most frequently used routes. Barriers to dissemination to non-research audiences existed at both organizational level (e.g., a lack of financial resources, platforms, and collaboration mechanisms) and individual level (e.g., a lack of time, knowledge, and skills, and uncertainty on how to disseminate). About a quarter of respondents (26.7%) had a dedicated person or team for dissemination in their unit or organization, with university researchers reporting a significantly higher proportion than their counterparts (P < 0.05). Only 14.2% of respondents always or usually used frameworks or theories to plan dissemination activities, 26.2% planned dissemination activities early, and 27.1% always or usually involved stakeholders in the research and dissemination process. Respondents with working experience in a practice or policy setting or dissemination and implementation training experience were more likely to apply these D4D strategies (P < 0.05).ConclusionConsiderable room exists for improvement in using impactful dissemination routes, tackling multiple barriers, providing organizational support, and applying D4D strategies among Chinese public health researchers. Our findings have implications for structural changes in academic incentive systems, collaborations and partnerships, funding priorities, and training opportunities.

Genetic counselors' research dissemination practices and attitudes.

Benefits have been demonstrated to disseminating aggregate research results to all relevant audiences, including study participants. Despite this, many health researchers face barriers in dissemination to broad audiences and returning aggregate results to participants is not commonly practiced. Due to their research presence and training in communication, genetic counselors can lead in implementing best practices in this area. We explored genetic counselors' current practices and opinions regarding educating study participants and wider audiences of research findings. We distributed a survey of 32 multiple-choice and open-ended questions to National Society of Genetics Counselors (NSGC) and Canadian Association of Genetic Counsellors (CAGC) members. Most respondents (90.1%, n = 128/142) identified with a responsibility to disseminate their research findings to a broad audience and identified several associated benefits. All respondents saw value in communicating aggregate results to study participants, although over half (53.2%, n = 66/124) had never done so. Genetic counselors reported resource and knowledge barriers to research dissemination. Despite expertise in education and communication, genetic counselors face similar barriers as other researchers toward broad dissemination of research. Formal training and professional guidelines specific to research dissemination practices will equip genetic counselors to reach broader audiences and maximize the impact of research findings.

Cloud-based data mapper (CDM): application for monitoring dry deposition of reactive nitrogen

Spatiotemporal monitoring of reactive nitrogen atmospheric deposition is essential for understanding its impact on sensitive ecosystems and quantifying cumulative effects. However, the sparsity of direct surface flux measurements combined with barriers in dissemination are major limiting factors in providing this information to decision makers and non-experts in a timely manner. This work addresses both aspects of this information gap by, 1) utilizing satellite-derived reactive nitrogen dry deposition data products that can be used by decision-makers to supplement the sparse direct surface flux measurements and 2) fill in measurement gaps. Therefore, we have developed a Reactive Nitrogen Flux Mapper (RNFM) component of the interactive Cloud-based Data Mapper (CDM) for providing easy access of satellite-derived reactive nitrogen (defined here as nitrogen dioxide (NO2) and ammonia (NH3)) dry deposition flux spatial maps/data to decision-makers/stakeholders over North America. The RNFM component of CDM has a Graphical User Interface (GUI) that allows users to specify the geographical regions and time periods for computing the average fluxes on the fly using an integrated cloud-based computing platform. The CDM architecture is flexible and can be upgraded in the future to take advantage of upstream satellite data directly on cloud platforms to provide results in near real-time.

Bat-Origin Swine Acute Diarrhea Syndrome Coronavirus Is Lethal to Neonatal Mice.

Bats are reservoirs for diverse coronaviruses, including swine acute diarrhea syndrome coronavirus (SADS-CoV). SADS-CoV has been reported to have broad cell tropism and inherent potential to cross host species barriers for dissemination. We rescued synthetic wild-type SADS-CoV using one-step assembly of a viral cDNA clone by homologous recombination in yeast. Furthermore, we characterized SADS-CoV replication in vitro and in neonatal mice. We found that SADS-CoV caused severe watery diarrhea, weight loss, and a 100% fatality rate in 7- and 14-day-old mice after intracerebral infection. We also detected SADS-CoV-specific N protein in the brain, lungs, spleen, and intestines of infected mice. Furthermore, SADS-CoV infection triggers excessive cytokine expression that encompasses a broad array of proinflammatory mediators, including interleukin 1β (IL-1β), IL-6, IL-8, tumor necrosis factor alpha (TNF-α), C-X-C motif chemokine ligand 10 (CXCL10), interferon beta (IFN-β), IFN-γ, and IFN-λ3. This study highlights the importance of identifying neonatal mice as a model for developing vaccines or antiviral drugs against SADS-CoV infection. IMPORTANCE SADS-CoV is the documented spillover of a bat coronavirus that causes severe disease in pigs. Pigs are in frequent contact with both humans and other animals and theoretically possess a greater chance, compared to many other species, of promoting cross-species viral transmission. SADS-CoV has been reported to have broad cell tropism and inherent potential to cross host species barriers for dissemination. Animal models are an essential feature of the vaccine design toolkit. Compared with neonatal piglets, the mouse is small, making it an economical choice for animal models for SADS-CoV vaccine design. This study showed the pathology of neonatal mice infected with SADS-CoV, which should be very useful for vaccine and antiviral studies.

Co-design of digital health interventions with young people: A scoping review.

Innovative health promotion strategies are crucial for enhancing global quality of life and curbing premature deaths. Digital health promotion is particularly impactful for young individuals often using internet-connected devices. Collaborative methodologies in digital intervention research offer insights into supporting youth during key life stages, such as adolescence. This review sought to examine the literature on digital health interventions for youth co-designed via participatory frameworks. Following the Joanna Briggs Institute Manual and an adapted Arksey & O'Malley's 6-stage framework, this review utilised the PRISMA-ScR checklist for structured reporting. Peer-reviewed research where young individuals (15-35 years) contributed to digital health intervention design was analysed. Systematic synthesis adhered to Braun & Clarke's Thematic Analysis Guidelines, mapping data to research queries and thematic framework. Eighteen articles were systematically synthesised, revealing seven main themes: digital tool, inquiry field, report aim, participatory activities, intervention attributes and behavioural change support. Seventeen distinctive digital health interventions were assessed, mostly within risk mitigation and mental health domains. Predominantly, interventions were web-based, with mental wellness websites emerging as the prevalent tool. User experience testing stood out as the primary reported outcome. Several innovative digital health interventions targeting youth have been identified. Platforms including social media, specialised apps, websites and video games are instrumental for health advice and clinical support dissemination, overcoming access and cost barriers. Participatory techniques are integral for the efficacy of digital health resources, encompassing youth aspirations and anticipations. Continued efforts will enrich comprehension of optimal practices in digital health promotion and intervention formulation.

Barriers to Citizen Science and Dissemination of Knowledge in Healthcare

Citizen science goes by many names, especially when citizen science is applied to healthcare and biomedicine: There are patient researchers, patient-driven innovators, lead users, quantified self-trackers, and more. Citizen science in healthcare goes beyond data collection; citizen scientists themselves perform many stages of science and research all the way through to dissemination of their work. They may find themselves facing barriers similar to those facing traditional academic researchers in academic publishing; however, these challenges are exacerbated by the very nature of citizen science, which is often individually driven and unfunded. Additional barriers in dissemination, such as structural barriers of journal publication systems, conscious and subconscious biases of editors and reviewers, the financial and time costs associated with dissemination, and more, can challenge citizen scientists. Some of the barriers are concrete while others are perceived but may be no less challenging. This essay highlights the barriers of citizen science work in healthcare, with special attention to the challenges of dissemination, including those experienced by a citizen scientist who has been addressing these challenges for nearly a decade. I provide three potential strategies with relevant examples for addressing some of the dissemination challenges, and provide additional dissemination advice—and encouragement—for citizen scientists in biomedicine and healthcare.

Perceived barriers in the dissemination of an organisational alcohol policy as part of implementing an alcohol prevention programme among managers

PurposeAn alcohol prevention programme, consisting of the implementation of an organisational alcohol policy and skills development training for managers, was delivered in Swedish workplaces. Previous findings revealed challenges in policy implementation because of the lack of dissemination amongst managers. This study aims to describe perceived dissemination barriers of the organisational alcohol policy by managers.Design/methodology/approachA cross-sectional survey (n = 193 managers) was performed to identify common dissemination barriers in the workplace and complementary case illustrations derived from semi-structured interviews (n = 18 managers) were used to understand the dissemination barriers of the organisational alcohol policy. Frequency distributions were presented to describe common perceived barriers.FindingsSixty-five per cent of managers reported that their workplace had not changed their approach to addressing alcohol-related issues compared to their usual practice before programme delivery. Various organisational factors, such as deprioritisation of programme dissemination, lack of communication and inadequate strategies were some of the common barriers perceived by managers. Moreover, managers reported uncertainties regarding any changes concerning the workplace’s approach for addressing alcohol-related issues. Increased efforts in disseminating the organisational alcohol policy can reduce uncertainties among managers.Practical implicationsA thorough process evaluation to understand processes in programme delivery and implementation is necessary to ensure the uptake of the intervention.Originality/valueThis study highlighted the complexity of disseminating an alcohol policy in a dynamic setting, such as the workplace, and provided the importance of addressing organisational obstacles.

The dissemination effect of human-computer interactive advertising news-Using the theory of media audience and emotion management.

The development and application of network media has seriously impacted the social information dissemination environment dominated by traditional media. To break the dissemination barriers encountered by traditional media, this work probes into the dissemination effect of human-computer interactive advertising news. An in-depth analysis of the current dissemination situation of interactive online advertising (IOA) is firstly conducted, and then the methods to effectively guide and manage audience emotions are studied. Finally, an improved LeNet-5 model is established to identify audience emotions. The improvement of the LeNet-5 model in this work is composed of the following four points. (1) The convolution module sets Inception_conv3 and Inception_conv5 are adopted to replace the third convolutional layer Conv3 and the fifth layer Conv5 of the LeNet-5, respectively. (2) The size of the convolution kernel is changed. The original convolution kernel is replaced by two 3 × 3 convolution kernels in the Inception_conv3 and Inception_conv5 module sets. (3) The number of convolution kernels is reasonably changed. (4) The Batch Normalization (BN) layer is used. The experimental results show that interactive advertisements have the better dissemination effects among the audiences with older age, higher education, and in more developed cities. The improved LeNet-5 network can effectively solve the over-fitting and gradient disappearance, with a good robustness. The recognition rate reaches more than 81%, which is higher than the traditional LeNet-5 network by 3%. It can be known that the accuracy of the improved LeNet-5 network image recognition is significantly promoted. This research provides a certain reference for the optimization of news dissemination.

Access and Experiences of Arabic Native Speakers With Disabilities on Social Media During and After the World Pandemic

Since the start of the coronavirus 2019 (COVID-19) outbreak, governments across the world have mobilized to inform citizens on the virus spread details, nation-level processes, and best health measures and practices to be taken. A large percentage of the media posted through the COVID-19 crisis has been graphical, which raised the question of whether Arabic-speaking blind and deaf persons were able to independently access reliable information. This article presents the results of two studies. The first study involves a content analysis of official social media posts about COVID-19 during critical phases of the outbreak via heuristic evaluation of WCAG2.1 on an iOS smartphone and an iPad. The second study explores the experiences of native Arabic-speaking blind and deaf persons on social media during the pandemic and curfew or lockdown periods in the State of Kuwait using a semi-structured interview (11 people who are blind/low vision and 7 people who are deaf). Overall, our findings highlight the accessibility gaps in the current government social media information content and its dissemination practices and barriers in providing information and services. Also, it gives insights into how people who are blind and people who are deaf are able to manage their lifestyle within and beyond the COVID-19 pandemic.

Key informant perspectives on sexual health services for travelling young adults: a qualitative study

BackgroundInternational travel has become increasingly popular among young adults. Young adults often engage in casual sexual relationships abroad, exhibit sexual risk behaviours and may thus be at risk of contracting sexually transmitted and blood-borne infections. Pre-travel interventions and consultations may mitigate this risk. At present, we know little about sexual health-related pre-travel interventions. The aim of this study was therefore to document key informants’ experiences, perceptions and recommendations in the context of sexual health of young adult travellers.MethodsKey informants were professionals working in Ottawa, Canada travel clinics, travel organizations or sexual health clinics with a young adult clientele. This study used a qualitative approach and consisted of 13 in-person or Skype semi-structured interviews with key informants. Thematic content analysis was informed by a sexual health framework, with themes emerging both inductively and deductively.ResultsSexual health was not common in pre-travel interventions described by key informants. Risk-assessment, and practical or purpose-driven pre-travel interventions were identified, resulting in risk mitigation strategies tailored to the destination region and/or mission/culture of the travel organization. Dissemination (e.g. limited time, lack of training) and uptake (e.g. young adults’ embarrassment, provider discomfort, financial constraints) barriers limited in-depth discussions of pre-travel interventions related to sexual health. Key informants acknowledged the importance of early sexual health education, and recommended ongoing, comprehensive sexual education for both youth and young adults.ConclusionThe findings of this study suggest that more time and resources should be allocated to the topic of sexual health during pre-travel interventions with young adults. Professionals who guide and prepare young adults for travel must develop concomitant skills in sexual health promotion. Early, comprehensive sexual education is recommended to improve overall sexual health in young adults and mitigate risk behaviours during travel.

An integrated approach for the evaluation of corporate foresight: the example of a Russian corporation

Purpose The purpose of this study is to develop an integrated approach to evaluating corporate foresight (CF) studies at all stages of its implementation and to test this approach using the example of a Russian state-owned corporation. Design/methodology/approach The use of foresight by companies as a part of their strategic activities is growing but still rather limited. To increase the effectiveness of foresight at the corporate level and ensure its justification, special approaches and criteria for its evaluation should be developed. To develop the approach to evaluation of CF which would be useful at all stages of foresight realization, at first, the authors focused the authors’ attention on identification of main challenges, problem and barriers, which arise during foresight process on the one hand, and exploring success factors and lessons learnt from different case studies on the other hand. On the basis of this literature analysis, the authors have formed a long list of evaluation criteria, which reflect accumulated experience in the field and all-important aspects to make foresight project successful and effective. On the next step, the authors related these criteria with stages of foresight realization and evaluation category. For pilot testing of this methodology, the authors used a case of Russian state-owned corporation. Findings This paper has presented an integrated approach to the evaluation of CF projects. The logic of the evaluation process of CF at all stages of its implementation is proposed; key evaluation topics (concept, objectives, project team, design of the project, project methodology, stakeholders, implementation, resources, results and its dissemination, effects and impact and barriers) are identified, and the corresponding sets of criteria are formed. Originality/value The originality of the work lies in using a wide experience of national foresight studies evaluation for corporations. The suggested approach could be used as a framework for CF evaluation. It was tested on the Russian state-owned company RussX.

Advances in Cognitive Remediation Training in Schizophrenia: A Review.

Cognitive Remediation Training (CRT) in schizophrenia has made great strides since its introduction in the 1990s. CRT was developed with the aim of improving the everyday functioning of individuals living with cognitive impairment. MEDLINE, PsychINFO, and Google Scholar were searched to extract peer-reviewed randomized controlled trials to produce the current review article. The aim of the present review is to summarize CRT effects on addressing cognitive changes in patients undergoing CRT as defined by the Cognitive Remediation Experts Workshop and to describe the areas of greatest impact in specific cognitive domains. Another area of this review aims to summarize the modalities of intervention (paper and pencil; computerized; home bound), the persistence of improvements, and their generalization to other domains of functioning. Finally, this review delineates barriers for wider dissemination of CRT, such as the transfer of research findings into clinical everyday practice and future developments of CRT.

Determinants of using children\u2019s mental health research in policymaking: variation by type of research use and phase of policy process

BackgroundResearch use in policymaking is multi-faceted and has been the focus of extensive study. However, virtually no quantitative studies have examined whether the determinants of research use vary according to the type of research use or phase of policy process. Understanding such variation is important for selecting the targets of implementation strategies that aim to increase the frequency of research use in policymaking.MethodsA web-based survey of US state agency officials involved with children’s mental health policymaking was conducted between December 2019 and February 2020 (n = 224, response rate = 33.7%, 49 states responding (98%), median respondents per state = 4). The dependent variables were composite scores of the frequency of using children’s mental health research in general, specific types of research use (i.e., conceptual, instrumental, tactical, imposed), and during different phases of the policy process (i.e., agenda setting, policy development, policy implementation). The independent variables were four composite scores of determinants of research use: agency leadership for research use, agency barriers to research use, research use skills, and dissemination barriers (e.g., lack of actionable messages/recommendations in research summaries, lack of interaction/collaboration with researchers). Separate multiple linear regression models estimated associations between determinant and frequency of research use scores.ResultsDeterminants of research use varied significantly by type of research use and phase of policy process. For example, agency leadership for research use was the only determinant significantly associated with imposed research use (β = 0.31, p < 0.001). Skills for research use were the only determinant associated with tactical research use (β = 0.17, p = 0.03) and were only associated with research use in the agenda-setting phase (β = 0.16, p = 0.04). Dissemination barriers were the most universal determinants of research use, as they were significantly and inversely associated with frequency of conceptual (β = −0.21, p = 0.01) and instrumental (β = −0.22, p = 0.01) research use and during all three phases of policy process.ConclusionsDecisions about the determinants to target with policy-focused implementation strategies—and the strategies that are selected to affect these targets—should reflect the specific types of research use that these strategies aim to influence.

Adaptive MPI collective operations based on evaluations in LogP model

Message passing model, represented by MPI (Message Passing Interface), is the principal parallel programming tool for distributed computer systems. The most of MPI-programs contain collective communications, which involve all the processes of a parallel program. Effectiveness of collective communications substantially effects on total time of program execution. In this work, we consider the problem of design of adaptive algorithms of collective communications on the example of barrier synchronization, which refers to one of the most common types of collective communications. We developed adaptive algorithm of barrier synchronization, which suboptimally selects barrier synchronization scheme in parallel MPI-programs among such algorithms as Central Counter, Combining Tree and Dissemination Barrier. The adaptive algorithm chooses the barrier algorithm with the minimal evaluation of execution time in the model LogP. Model LogP considers performance of computational resources and interconnect for point-to-point communications. Proposed algorithm has been implemented for MPI. We present the results of experiments on cluster systems, analyse dependency of algorithm selection on LogP parameters values. In particular, for the number of processes less than 20 adaptive algorithm selects Combining Tree, while for a larger number of processes adaptive algorithm selects Dissemination Barrier. Developed algorithm minimizes average time of barrier synchronization by 4%, in comparison with the most common determined barrier algorithms.

Porcine reproductive and respiratory syndrome virus dissemination across pig production systems in the United States

Porcine reproductive and respiratory syndrome virus (PRRSV) remains widespread in the North American pig population. Despite improvements in virus characterization, it is unclear whether PRRSV infections are a product of viral circulation within production systems (local) or across production systems (external). Here, we examined the local and external dissemination dynamics of PRRSV and the processes facilitating its spread in three production systems. Overall, PRRSV genetic diversity has declined since 2018, while phylodynamic results support frequent external transmission. We found that PRRSV dissemination predominantly occurred mostly through transmission between farms of different production companies for several months, especially from November until May, a timeframe already established as PRRSV season. Although local PRRSV dissemination occurred mainly through regular pig flow (from sow to nursery and then to finisher farms), an important flux of PRRSV dissemination also occurred in the opposite direction, from finisher to sow and nursery farms, highlighting the importance of downstream farms as sources of the virus. Our results also showed that farms with pig densities of 500 to 1,000 pig/km2 and farms located at a range within 0.5km and 0.7km from major roads were more likely to be infected by PRRSV, whereas farms at an elevation of 41 to 61 meters and surrounded by denser vegetation were less likely to be infected, indicating their role as dissemination barriers. In conclusion, our results demonstrate that external dissemination was intense, and reinforce the importance of farm proximity on PRRSV spread. Thus, consideration of farm location, geographic characteristics and animal densities across production systems may help to forecast PRRSV collateral dissemination.

The Status and Patterns of open Access in Research Output of Most Productive Indian Institutions

Open Access is emerging as an important movement worldwide since last few years, triggered mainly by the high subscription cost of pay walled journals that create barriers in universal dissemination of knowledge reported in those journals. The paywall barriers to access of knowledge has become so problematic that even institutions in the developed countries are not only cancelling subscriptions but also mandating it for their researchers to either publish in open access journals or at least deposit their research papers in Institutional Repositories. The high subscription cost of journals is a more serious issue for developing countries, as it takes away institutional resources that can be used for other productive purposes. India has taken several steps in promoting open access, including release of an open access policy by Ministry of Science and Technology, however, it is not very clear that how effective these initiatives have been. This paper intends to address this issue. It examines published output, indexed in Web of Science, from 100 most productive institutions in India and analyze how much research output coming from them are available in Open Access (OA). The paper further analyzes availability of research papers from these institutions in the popular pirate site Sci-Hub. It is interesting to observe that legal OA percentages are significantly lesser than the Sci-Hub availability for all the institutions, an indication that the existing systems for promoting open access in India are not working efficiently. At the end, the paper also presents statistics about number of papers deposited in three central institutional repositories in India. These statistics provides an indication of the extent to which these repositories have been able to promote open access in India. The paper concludes by pointing to some factors that impede Open Access in India.