British Journal of Clinical PharmacologyVolume 7, Issue 1 p. 119-120 Free Access Altered elimination of desmethyldiazepam in the elderly. U Klotz, U KlotzSearch for more papers by this authorP Muller-Seydlitz, P Muller-SeydlitzSearch for more papers by this author U Klotz, U KlotzSearch for more papers by this authorP Muller-Seydlitz, P Muller-SeydlitzSearch for more papers by this author First published: January 1979 https://doi.org/10.1111/j.1365-2125.1979.tb00908.xCitations: 28AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. References BOSTON COLLABORATIVE SURVEILLANCE DRUG PROGRAM (1973). Clinical depression of the central nervous system due to diazepam and chlordiazepoxide in relation to cigarette smoking and age. N. Engl. J. Med., 288, 277– 280. Gibaldi, M., Nagashima, R. & Levy, G. (1969). Relationship between drug concentration in plasma or serum and amount of drug in the body. J. pharm. Sci., 58, 193– 197. Klotz, U., Avant, G.R., Hoyumpa, A., Schenker, S. & Wilkinson, G.R. (1975). Effects of age and liver disease on the disposition and elimination of diazepam in adult man. J. clin. Invest., 55, 347– 359. Klotz, U., Antonin, K.H. & Bieck, P.R. (1976). Comparison of the pharmacokinetics of diazepam after single and subchronic doses. Eur. J. clin. Pharmac., 10, 121– 126. Kraus, J.W., Desmond, P.V., Marshall, J.P., Johnson, R.F., Schenker, S. & Wilkinson, G.R. (1978). The effects of aging and liver disease on the disposition of lorazepam in man. Clin. Pharmac. Ther., 24, 411– 419. Randall, L.O., Scheckel, C.L. & Banzinger, R.F. (1965). Pharmacology of the metabolites of chlordiazepoxide and diazepam. Curr. Ther. Res., 7, 590– 606. Roberts, R.K., Wilkinson, G.R., Branch, R.A. & Schenker, S. (1978). The effect of age and parenchymal liver disease on the disposition and elimination of chlordiazepoxide. Gastroenterology, 75, 479– 485. Schwartz, M.A., Koechlin, B.A., Postma, E., Palmer, S. & Krol, G. (1965). Metabolism of diazepam in rat, dog, and man. J. Pharmac. exp. Ther., 149, 423– 435. Shader, R.I., Greenblatt, D.J., Harmatz, J.S., Franke, K. & Koch-Weser, J. (1977). Absorption and disposition of chlordiazepoxide in young and elderly male volunteers. J. clin. Pharmac., 17, 709– 718. Shull, H.J., Wilkinson, G.R., Johnson, R.F. & Schenker, S. (1976). Normal elimination of oxazepam in acute viral hepatitis and cirrhosis. Ann. intern. Med., 84, 420– 425. Westlake, W.J. (1970). Time integral of drug concentration in the central (plasma) compartment. J. pharm. Sci., 59, 722– 723. Citing Literature Volume7, Issue1January 1979Pages 119-120 ReferencesRelatedInformation