We investigate the intrachannel cross-phase modulation (IXPM)-induced phase shift in optical return-to-zero pulse propagating in a periodically dispersion-managed long-haul optical fiber transmission line. Necessary dynamical equations for various pulse parameters have been derived using variational analysis to estimate the phase shift. These equations are solved by the Runge–Kutta method. The analytical result is verified by numerical simulation based on split-step Fourier method. We therefore explore the effects of various parameters, such as transmission distance, input power, duty cycle, dispersion map strength, and residual dispersion, on phase shift for a 40 Gb/s single-channel transmission system. We also check the impact of variation of bit rate on phase shift. We find that IXPM-induced phase shift can be mitigated by proper adjustment of dispersion management and different pulse parameters like duty cycle, dispersion map strength, and peak power.