Dislocation Of Cervical Vertebra Research Articles

The effect of ethanol extracts of loulu flower on LPS-induced acute lung injury in mice

Ethnopharmacological relevanceIn Mongolian medicine, Loulu flower (LLF), the dried inflorescence of Rhaponticum uniflorum (L.) DC. from the Compositae family, has been used to clear heat and relieve toxicity for millennia, particularly in the treatment of pneumonia. Aim of this studyTo reveal the effects of LLF on mice with lipopolysaccharide (LPS)-stimulated acute lung injury (ALI) and elucidate the underlying mechanisms. Materials and methodsALI was established in BALB/c mice via nasal drops administration of LPS (5 mg/kg). The mice were then orally administrated with various doses of LLF extracts and the positive drug dexamethasone (DEX, 5 mg/kg), once daily for seven consecutive days. Last day, after being stimulated with LPS for 6h, the mice were closed dislocation of cervical vertebra, the serum, bronchus alveolar lavage fluid (BALF) and lung tissue were put into the EP tube and stored at −80 °C for further analysis. The changes of histopathology were tested by hematoxylin and eosin stain (H&E), the levels of, IL-1β, IL-18, TNF-α and IL-4 in BALF and serum were measured by ELISA. The pathways related to the treatment of ALI were predicted by network pharmacology. The expression levels of TLR4/NF-κB and NLRP3 signaling pathway-associated proteins, COX-2 and ERK were tested by western blotting. The levels of P65 and NLRP3 in lung tissues were determined by immunofluorescence analysis. ResultsLLF total extract and the extract parts could alleviate the inflammatory cell infiltration, thicken the alveolar walls in lung tissues, reduce the levels of IL-18, IL-1β in BALF, the TNF-α in both BALF and serum, meantime enhance the level of IL-4 in BALF and serum in mice with LPS-induced ALI. Our network pharmacology and comprehensive gene ontology analyses revealed the active constituents of LLF and the pathways, including TLR4/NF-κB, NLRP3 and MAPK signaling pathways, which play significant roles in ALI. Furthermore, both the total extract and its extraction portions suppressed the expressions of proteins related with the COX-2, p-ERK and TLR4/NF-κB signaling pathway (TLR4, p-IκB, p-p65), as well as the NLRP3 signaling pathway (NLRP3, cleaved caspase-1, caspase-1, IL-1β). ConclusionLLF could improve the pathological changes and reducing inflammatory reactions in mice induced by LPS. The mechanism may be related to the modulation of the TLR4/NLRP3 signaling pathways.

Application of guide combined with probing the internal wall of pedicle screw trajectory for subaxial cervical pedicle screw placement

To investigate the skill and evaluate the accuracy for application of guide combined with probing the internal wall of pedicle screw trajectory for subaxial cervical pedicle screw placement. Subaxial cervical pedicle screw was inserted in 11 patients by the guide combined with probing the internal wall of pedicle screw trajectory from January 2014 to October 2016, including 7 males and 4 females with an average age of 48.1 years(ranged 32 to 63 years). There were 4 cases with cervical spondylotic myelopathy, 4 with fracture and dislocation of cervical vertebrae, 1 with cervical cord injury without fracture and dislocation, and 2 with atlantoaxialfracture and dislocation. The target pedicle's diameter, optimal entry point, sagittal angle and cross-sectional angle were measured by CT before operation. During operation, the pedicle screw inserted angle was controlled by a guide with a self-designed protractor and probed the internal wall of pedicle screw trajectory as medial safety margin of insertion screw. The accuracy of cervical pedicle screw was evaluated by CT with classification of four grades and assessed whether there was injury of spine cord or vertebral artery postoperatively. Seventy-one cervical pedicle screws were placed among 11 patients, and no one had been found with clinical manifestations of injury of spine cord (or nerve root) or vertebral artery after operation. According to postoperative CT scan for evaluating the grade of screw position, 52 screws were in grade 0, 13 in grade 1, 4 in grade 2, 2 in grade 3, and 91% (65/71) located in good position. In total, 6 screws were incorreted in placement, and 4 cases of them broke medial wall and 2 cases broke lateral wall. The method of probing the internal wall of pedicle screw trajectory for subaxial cervical pedicle screw placement is safe and reliable, but the studying curve is long. Probing the internal wall of pedicle screw trajectory and controlling the insertion angle by guide with a protractor are key points of this technology.

Safety Performance of the Full Harness in Various Falling Postures of Wearer

Fundamental safety measure for falling is to prepare flat and effective wide workplace with guardrails. However, their countermeasures may be difficult to apply for short-duration works and disaster relief works. In such cases, the fall arrest system has been applied to the height workplaces. This study focuses on fundamental characteristics of full body harness in various postures of wearer during falling. Three kinds of situation, such as (1) leg first fall, (2) head first fall, and (3) stop falling when the wearer body in parallel to the ground, were considered to recognize the performance. Experiments were carried out using 735N of human dummy, called HybridIII pedestrian 50%tile model in the automobile industry. The shock-absorber of the Lanyards used in this study were designed about 4kN. Impact force acting on hook, head accelerations, and a chest displacement were measured during falling. From the results, not only the vertical acceleration of the human dummy but also horizontal were measured. Due to the horizontal acceleration, a huge bending moment acting on the dummy's neck observed in several situations. It indicates that the wearer may have risks of whiplash or more serious injuries such as dislocation of cervical vertebrae or spinal injuries. Chest deformations measured in this study were not also small for aged workers. It indicates that there are some risks of rid fractures or related chest injuries. The back of the head crashed aggressively to the D-ring of the full harness when the dummy rebounded due to stop falling by lanyard. Therefore, special helmet to resist the impact force due to D-ring, and the design force of shock-absorber should be reconsidered.

Fractured cervical vertebra in accidental strangulation by chunni

Accidental ligature strangulation though rare, is occasionally reported and circumstantial evidence alone can sufficiently indicate the accidental nature of the occurrence. While it is recognized that fracture and dislocation of the cervical vertebra are seen in judicial hanging or hanging associated with a long drop, it is not reported in ligature strangulation. In the present case, a 15 year-old female was accidentally strangled when her chunni was caught in a rear wheel of a motorcycle while sitting on the pillion. She was immediately taken to the nearest hospital in an unconscious condition. She died after a period of 4 days. The autopsy revealed fracture and dislocation of the 5th cervical vertebra with extensive bruising of the deep muscles of the neck apart from the ligature mark around the neck. Fracture and dislocation of the cervical vertebra in accidental ligature strangulation by chunni are very rare and has not been reported previously.

Delayed Esophageal Perforation: A Complication of Anterior Cervical Spine Fixation

Delayed Esophageal Perforation: A Complication of Anterior Cervical Spine Fixation

Breech presentation with hyperextension of the neck and intrauterine dislocation of cervical vertebrae

Breech presentation with hyperextension of the neck and intrauterine dislocation of cervical vertebrae

Dislocation of Cervical Vertebra as Result of a Fall

Dislocation of Cervical Vertebra as Result of a Fall