Degree Of Disintegration Research Articles

Effect of the inclusion complex formation method on the functional properties of poly (butylene adipate co-terephthalate) active films

The food waste and single-use packaging problems require efforts to develop active, sustainable packaging to extend the shelf life of perishable products. Therefore, the β-Cyclodextrin-Clove essential oil inclusion complexes (IC) obtained by ultrasound (IC-U) and kneading (IC-K) methods were incorporated into a PBAT matrix. The effect of the IC on the structural, functional, and biodegradability features of the PBAT matrix was assessed. The results show that the IC exhibited high thermal stability and adequate dispersion in the PBAT matrix during the extrusion process. The PBAT-IC films, as prototypes of packaging bags, improved the shelf life of perishable foods (blueberries), reducing their weight loss by 20 % and 8 % after 28 days at room and refrigerated temperatures, preserving the diameter of the blueberries and inhibiting fungal growth, corroborating an improvement in functional properties. Moreover, IC-U and IC-K incorporation did not affect Young's modulus (85 N/mm²), tensile strength (19 N/mm²), elongation at break (553 %), and disintegration degree (90 %) of the films, making them alternative food preservation packaging for the food industry.

Disintegration of commercial single-use plastics from synthetic and biobased origins and effects on plant growth

Many single–use plastic (SUP) options made of synthetic polymers, bio-based materials, and blends of both are available in the market and used in large quantities. The disintegration of eleven commercial SUP, marketed in Mexico as cups and plates, was investigated in an aerobic home compost environment at a laboratory scale over 180 days. An evaluation of chemical changes, surface morphology, and thermal and mechanical properties was conducted to ascertain the original composition of SUP and the progression of disintegration in samples that are challenging to clean from soil contamination. Furthermore, the impact of residual compost on barley (Hordeum vulgare) plant growth and its correlation with the leaching of heavy metals were explored. The bio-based SUP, but not those made of expanded polystyrene foam, showed a correlation between the disintegration degree (measured by weight loss into particles <2 mm) and a decrease in functional groups (observed by FT-IR), mechanical-thermal stability loss, and surface wear over disintegration time. For instance, the highest disintegration at 180 days was approximately 70 % for wheat bran and palm leaf plates, followed by wheat plates and cellulose-PLA cups (60 %). In addition to the components listed by the manufacturers, the FT-IR and DSC analysis revealed the presence of polyethylene and polypropylene in cellulose cups and sugarcane plates. These components, impede disintegration but contribute to preserving thermal resistance and hydrophobicity during utilization. Compost derived from expanded polystyrene foam SUP, with 90 days of disintegration, was rich in zinc and chromium and significantly decrease in the root length of the barley plant compared to the control. This demonstrates the necessity of considering the impact of the leaching of additives and secondary microplastics into the environment.

Enhancing degradation of PLA-made rigid biodegradable plastics with non-thermal plasma treatment

This study evaluated the efficacy of Dielectric Barrier Discharge Non-Thermal Plasma (DDBD-NTP) as a pretreatment method to enhance the degradation of rigid biodegradable plastics (RBP) during composting, specifically focusing on polylactic acid (PLA) products such as drinking cups (CS) and spoon handles (SH). Using a Single-Factor-At-A-Time (SFAT) design, the impact of NTP parameters, including input voltage and treatment duration, on the physicochemical properties was evaluated, and the subsequent degradation rate of RBP was assessed by measuring the degree of disintegration in a home-scale composter. The filamentary discharge mode of the DDBD plasma system selectively altered the surface characteristics of RBP without significantly affecting their bulk properties. High-voltage treatments significantly increased surface roughness and accelerated degradation rates, while low-voltage and short-duration treatments enhanced oxidation, as indicated by the increased O/C ratio (85.5% for SH and 66.1% for CS), showing a non-linear response to plasma intensity. Furthermore, NTP treatment reduced water contact angles (up to a 39.79% reduction for SH and 82.65% for CS), indicating enhanced hydrophilicity. All NTP-treated samples demonstrated significantly higher degradation rates compared to both untreated and thermally treated counterparts. Notably, ‘high-voltage for short-duration’ treatments, such as CS-3 and SH-3, exhibited the highest degradation rates among the samples. CS-3 achieved complete disintegration (100%) within 20 days, markedly exceeding the 2% observed in untreated CS samples. Similarly, SH-3 reached 36% disintegration after 35 days, considerably surpassing the 9% seen in untreated SH samples. The findings indicate that NTP treatment is a viable and sustainable method to enhance the biodegradation of plastic waste.

Innovative waste activated sludge pre-treatment using a raceway pond Reactor: Integration of Low-Temperature and solar radiation

A novel pre-treatment, using a raceway pond reactor (RPR), combining the use of thermal and solar effects, was applied to enhance anaerobic digestion (AD) of waste activated sludge (WAS) from an urban wastewater treatment plant. Thermal pre-treatment at 25, 50, 60 and 70 °C was carried out for 5 h with (under distinct values of UV radiant power) and without solar radiation and varying WAS depth in the RPR (5 or 7 cm). Higher temperatures (60 and 70 °C) and longer treatment times (3 to 5 h) resulted in increased disintegration of bacterial cells. The WAS pre-treatment significantly (p-value ≤ 0.001) boosted soluble chemical oxygen demand (SCOD) levels, achieving a disintegration degree of 19.7 % at 70 °C with solar radiation (7.2 kJUV L-1WAS), which corresponds to a 15-fold increase of SCOD, compared to the baseline at 25 °C without radiation. Moreover, at the highest temperature (70 °C), there was a significant SCOD increase (p-value ≤ 0.05) of approximately 400 mgO2 L-1 in the presence of solar radiation. This synergetic effect between temperature and solar radiation caused cell damage, membrane rupture, and release of cellular content, shifting extracellular polymeric substances from tightly bound to loosely bound and soluble fractions, consequently improving methane production. Methane production increased by 131 % compared to the control (25 °C) under 70 °C and after 7.2 kJUV L-1WAS, indicating a positive impact on WAS hydrolysis. The technology adopted in this work fosters methane production predominantly using renewable solar energy without chemical residues. This is the first report on RPR for WAS pre-treatment, combining mild temperature and solar radiation.

Hydrodynamic disintegration effects assessment by CFD modelling integrated with bench tests

The hydrodynamic disintegration process depends, among others, on operational parameters like rotational speed or introduced energy. The study presents an interdisciplinary approach to the hydrodynamic disintegration parameters impact assessment on the internal processes and disintegration effects on the example of sewage sludge treatment. Three rotational speeds were considered, including fluid properties change at selected disintegration stages. Disintegration effects were measured in the bench tests. Soluble chemical oxygen demand (SCOD) and volatile fatty acids (VFA) were measured before and after disintegration process. The assessment of the effects of disintegration employed the disintegration degree and the assessment of the course of methane production employed biochemical methane potential (BMP) tests. Fluid properties change during the disintegration stages does not cause a significant change in the flow structure. Due to the mathematical modelling results, at 1500 rpm no cavitation phenomenon was observed. Although, the bench tests results indicates, for the rotational speed 1500 rpm, organic compounds released to the liquid were characterised by higher susceptibility to biological decomposition than those released for 2500 and 3000 rpm (as suggested by the low SCOD/VFA values for 1500 rpm). Obtained results have confirmed, that the main phenomenon responsible for the disintegration effect is mechanical shredding not cavitation.

Double Strength Reduction Method for Carbonaceous Rock Slope Considering Influence of Disintegration Degree

Double Strength Reduction Method for Carbonaceous Rock Slope Considering Influence of Disintegration Degree

Effects of microwave irradiation at various temperatures on biosludge disintegration

ABSTRACT The waste biological sludge disintegration by using microwave irradiation was investigated at a ramping rate of 2°C/min and 5 min holding time at various target temperatures. Significant disintegration of biosludge was observed and the highest disintegration degree was determined about 82% at the temperature of 110°C. Increase of target temperature elevated the energy needs to 98, 123 and 148 kWh/kg TS at the temperatures of 75°C, 90°C and 110°C, respectively. The gradual increase of sugar and protein in the sludge slurry with increasing temperatures indicates successful degradation. The microwave pretreatment increased the specific surface area of the sludge by particle size reduction. The specific surface area of raw sludge was 70 m2/kg and rose to approximately 253.7 m2/kg at 110°C with an increment ratio of 260%. Although a significant NH4–N release was not observed, PO4–P concentrations increased from 11.0 mg/L to 16.3, 20.7 and 29.2 mg/L at the temperatures of 75°C, 90°C, 110°C, respectively. While the specific filter resistance of waste biological sludge was about 1.0 × 1013, increasing the microwave target temperature, the ability of dewatering decreased and the highest SFR value of 5.1 × 1014 was observed at the temperature of 110°C.

Study of the Corrosion Inhibition Efficiency by Using New Azo Compounds from Thiazole Derivatives

Azo compounds were prepared by reacting thiazole derivatives with 2-naphthol, o-vanillin, 4-(dimethyl amino) pyridine, and 4-bromo aniline with thiazole derivatives. The molar conductivity of the azo compounds prepared in this study was measured using (ethanol) as a solvent and at room temperature, all compounds showed non-electrolytic behavior. The compounds were characterized by TGA/DTA, studying the thermal stability and calculating the activation energy of azo compounds, where the thermal analyses of the prepared compounds were measured to identify the temperature at which the compound disintegrates, as the compound has more than one degree of disintegration, and this variation in the degrees of disintegration and the remaining materials depends on the nature of the compound and the type of groups present in it, as well as the efficiency of their use as materials. Resistant to corrosion by weight loss method with different concentrations at constant temperature. The higher the concentration, the greater the inhibition efficiency.

Effect of Inlet Pressure on the Biodegradability Index of Cavitated Herbal Waste

This paper analyzes the effect of inlet pressure on the index of biodegradability of cavitated herbal waste (HW) following its suspension in mechanically treated wastewater (MTW) for further biological processes. Hydrodynamic cavitation (HC) was carried out at inlet pressures of 3.5, 5.0, and 7.0 bar. The BOD5/COD ratio increased by 30% between the 5th and 10th minutes of the process, with the inlet pressure amounting to 3.5 bar, which indicated increased biodegradability of HW. For the higher inlet pressures used, the value of the biodegradability index (BI) increased by 23% and 13% for 5.0 and 7.0 bar, respectively, after 60 min of the process. The value of COD as well as the VS, TS, TC and TOC concentrations dropped for each analyzed inlet pressure, which indicated that complex organic compounds were effectively destroyed. The highest disintegration degree (DDCOD) was achieved with an inlet pressure of 3.5 bar. SEM analysis was performed to analyze the changing morphological structure of the HW. It was proven that the structural morphology of the herbal waste was significantly influenced by hydrodynamic cavitation, which could affect subsequent biological processing.

Unskilled Migration and Vertical Disintegration: Theory and Evidence from China

This paper studies how rural-urban migration in China affects the vertical disintegration of firms. We construct a theoretical model and find that the inflow of rural migrants increases the output of firms in urban areas. This leads to a higher degree of vertical disintegration of firms due to the decreasing returns to scale. We also find that the wage of skilled workers relative to that of unskilled workers in urban areas is increased with rural migrants as the vast majority of rural migrants are unskilled. Our empirical findings are consistent with our model predictions using China’s population census and manufacturing firm-level data in 2005.

Enhancing short-chain fatty acids production via acidogenic fermentation of municipal sewage sludge: Effect of sludge characteristics and peroxydisulfate pre-oxidation.

This study first employed a combined pretreatment of low-dose peroxy-disulfate (PDS) and initial pH 10 to promote short-chain fatty acids (SCFAs) production via acidogenic fermentation using different types of sewage sludge as substrates. The experimental results showed that the yield of maximal SCFAs and acetate proportion after the combined pretreatment were 1513.82±28.25mg chemical oxygen demand (COD)/L and 53.64%, and promoted by 1.28 and 1.56 times higher, respectively, compared to the sole initial pH 10 pretreatment. Furthermore, in terms of the disintegration degree of sewage sludge, it increased by more than 18% with the combined pretreatment compared to the pretreatment of sole initial pH 10. Waste-activated sludge (WAS) from A2/O and Bardenpho processes were more biodegradable, explained by the 1.47- and 1.35-times higher disintegration rate than those from oxidation ditch and they favored acetate dominant fermentation. Correlation analysis revealed a strong correlation (p ≤ 0.01) between SCFAs production and soluble COD, total proteins, proteins in soluble-extracellular polymeric substances (SEPS), total polysaccharides, and polysaccharides in SEPS. Mechanism explorations showed that preoxidation with PDS enhanced the solubilization and biodegradability of complex substrates, and altered the microbial community structure during the fermentation process. Firmicutes and Tetrasphaera were proven to play a key role in improving SCFA production, especially in promoting acetate production by converting additional SCFAs into acetate. Additionally, the addition of PDS greatly promoted sulfur and iron-related metabolic activities. Finally, the combined pretreatment was estimated to be a cost-effective solution for reutilizing and treating Fe-sludge.

Origin of Fracture-Controlled Conduits in Calcite-Rich Highly Productive Aquifers Impregnated with Diagenetic Silica

The origin of highly permeable flow paths in carbonate-siliciclastic rocks, such as large-aperture fractures in aquifers in the Eastern Bohemian Cretaceous Basin (EBCB), is poorly understood. The karst potential was assessed from the rock carbonate content and the degree of disintegration after leaching in HCl. Surprisingly, dissolution of calcite in EBCB usually did not lead to rock disintegration until calcite &gt; 78%. Instead, porosity increased significantly. High-porosity rock is held together by microns-thick secondary silica cement with a foam-like structure and considerable tensile strength. Three types of conduits occur in the EBCB: (i) bedding-parallel conduits associated with calcite-rich layers, (ii) subvertical fracture swarm conduits that develop on damaged zones of fracture swarms, and (iii) conduits formed by dissolution of calcite veins by groundwater flow. These are ghost-rock karst features where calcite is leached from the rock in the first phase and the residue is washed out by conduits under steep hydraulic gradients in the second phase. Very similar features have been described in Minnesota and Wisconsin, USA. Research has shown that fractures with sharp-edged walls that give the impression of an extensional tectonics origin may actually be ghost-rock karst features in which dissolution and piping have played an important role in their enlargement.

UV-C pretreatment of wastewater-grown algal biomass for recover of biofuel precursors

In the present study, ultraviolet radiation C (UV-C) was used as a pretreatment tool for the optimal recovery of biofuel precursors from algae Chlorella vulgaris. The pretreatment efficiency of UV-C with fixed light intensity (1.173 mWcm−2) on 1.5 gL-1 algal biomass was observed at 0, 0.5, 1, 2, 5, 10, and 20 h of irradiation by measuring the released sugar content and soluble chemical oxygen demand (sCOD). The UV-C pretreated algal cells were also analyzed through impedance spectroscopy, fluorescence microscope, and digital images to assess the degree of cell wall disintegration. The released sugar content reached a maximum of 73.61 mg L-1 at 10 h of exposure, whereas the maximum sCOD of 190 mg L-1 was achieved at 20 h exposure. Image analysis indicated that the chlorophyll content declined exponentially from 7.21 to 0.14 µgmL-1 with UV-C exposure. An increase in UV-C exposure time resulted in decreased impedance and increased conductance. The SYTOX green fluorescence also increased with 10 h of exposure, followed by a decline. Therefore, the cell wall stability gets compromised and the permeability increases with increment in UV-C exposure. This triggers extensive release in cell wall sugar content with exposure. Further exposure destabilizes the cell wall leading to discreet breakage. This breakage disperses internal content to bulk liquid, causing elevated sCOD with reduced sugar content. The present study showed that UV-C to be a potential pretreatment strategy to release precursors to derive biofuels such as biohydrogen, bioethanol and others.

Effect of mechanical properties on in vitro dynamic digestion of starch contained in hydrogels.

This study evaluates the effect of mechanical properties on the in vitro dynamic gastrointestinal digestion of hydrogels containing starch (HCSs) as a model for studying the nutrient digestibility of solid foods. It provides a useful theoretical basis for the processing of specific foods. Four types of HCSs with two levels of fracture stress (17.4-20.9 kPa and 55.5-57.6 kPa) and two levels of fracture strain (25.4-28.5% and 53.7-57.4%) were prepared. For these HCSs, the degree of gastric disintegration of hydrogels reduced significantly when fracture strain exceeded 30% (P < 0.05). The gastric emptying of HCS particles was also affected by mechanical properties. For example, even at the same level of fracture stress (ca. 20 kPa), the dry solids retention ratio decreased markedly from 0.90 to 0.43 with a decrease in fracture strain from 53.7% to 25.4% (P < 0.05). For the starch hydrolysis of HCSs after gastric digestion, more than 70% of starch in the particles of all types of HCSs emptied did not undergo digestion. The starch hydrolysis of HCSs during small intestinal digestion was also influenced by their mechanical properties. Fracture strains of HCSs, rather than their fracture stress, affected starch digestibility in hydrogels. The gastric disintegration, the gastric emptying, and the starch hydrolysis of HCSs are suppressed when fracture strain exceeded 30%. Even with the amount of nutritional components contained in hydrogels being the same, the in vitro gastrointestinal digestion behavior of HCSs depends on their mechanical properties. This behavior has the potential to be used in the design of processed foods with controlled bioaccessibility. © 2023 Society of Chemical Industry.

Plasticizing effect of depolymerized suberin derivatives from natural cork and potato periderm in poly(lactic acid) (PLA) for improved toughness and processability

In this study, the inherent brittleness of biodegradable poly(lactic acid) (PLA) was mitigated through the utilization of a carbon-neutral biomass—depolymerized suberin derivatives (DSDs)—as a plasticizer. The DSDs were subjected to repolymerization under mild conditions, resulting in weight-average molecular weights of 2744 g/mol and 11546 g/mol. These polymerized DSDs (pDSDs) were subsequently blended with PLA, leading to a notable reduction in the glass transition temperature of the blends, confirmed through differential scanning calorimetry (DSC) and dynamic mechanical analysis (DMA) characterizations. Remarkably, the tensile toughness exhibited a substantial increase up to 1148% from 0.56 MJ/m3 in the neat PLA to a range of 4.37–6.99 MJ/m3 for blends incorporating more than 3 wt% of pDSDs. Furthermore, the blends demonstrated a marked reduction in shear viscosity compared to neat PLA, corroborated by an increased melt flow index which shifted from 10.0 g/10 min to a range of 29.3–33.3 g/10 min. This alteration promises to be beneficial in enhancing the quality and producibility during the injection molding process. Importantly, the biodegradability of the pDSDs/PLA blends remained comparable to that of the neat PLA, showing a 90% degree of disintegration in 12 weeks from the biodisintegration test. This study can pave the way to valorize other bio-based materials with aliphatic compounds for the plasticizing modification of various polymers. Furthermore, understanding the interactions between different bio-based aliphatic compounds and various polymers could lead to tailor-made solutions for specific applications, ranging from biomedical devices to structural parts, further broadening the scope of biodegradable and sustainable materials in many engineering fields.

The influence of additives on the characteristics of earth-based mortar on the example of ancient stone structures in the Black Sea Basin

The article describes the possible ways to modify the parameters of earth-based mortar used for the reconstruction of masonry structures on excavations located in the Black Sea area - archaeological site in Tyritake in Kerch on the Crimean Peninsula and Tanais near Rostov-on-Don in Russia. The structures we meet during these archaeological missions are irregular walls made of lime rock on earth-based mortar, which show a significant degree of disintegration due to the poor properties of the mortar and destructive atmospheric impacts. To carry out their reconstruction, it is necessary to select a mortar with appropriate parameters following conservation principles. Since earth-based mortar does not have sufficient characteristics, various possibilities for modification of its composition were considered, such as the addition of hydrated and hydraulic lime or cement. The compressive strength, adhesion, and durability parameters for unmodified and modified mortars were compared. Also, the issue of compatibility of the new reconstruction mortar with the existing stone material will be highlighted, which is crucial in the selection of material for the reconstruction of historic buildings.

Disintegration behavior and its grading entropy characterization of polyurea modified graded carbonaceous mudstone under loading and drying-wetting cycles

To study the disintegration behavior and characterization indexes of Modified Graded Carbonaceous Mudstone (MGCM), soaking disintegration tests of MGCM under vertical loading and cyclic drying-wetting were carried out with a disintegration test instrument which self-designed by our team. The grain size distribution of MGCM during drying-wetting cycles was analysed. Standard basal entropy, as an important parameter of grading entropy that quantitatively characterizes distribution curves, was introduced to characterize the disintegration behavior of MGCM and correlated with the comprehensive evaluation index, namely, disintegration ratio. The results show that as the number of drying-wetting cycles increases, the Graded Carbonaceous Mudstone (GCM) blocks disintegrate rapidly and the fine-grain content increases. With an increase in vertical load, the particles disintegrate more completely. The contents of each particle group in the GCM test groups stabilize after 9, 7, and 4 drying-wetting cycles under vertical loads of 0, 100, and 200 kPa, respectively. Under the same vertical load of 200 kPa, the contents of each particle group in MGCM test groups with Polyurea (PU) content 0, 5, and 10 wt% stabilize after 4, 6, and 8 drying-wetting cycles, respectively. The inclusion of PU can effectively retard the disintegration of GCM, and the effect is more pronounced with 5 wt% PU content compared to 10 wt%. However, it is also susceptible to the deterioration of PU layer caused by mechanical screen. The grading entropy model of MGCM under loading and cyclic drying-wetting is established. There is a significant positive, linear correlation between the standard basal entropy and the disintegration ratio. A smaller standard basal entropy to a smaller disintegration ratio, indicating a greater degree of particle disintegration and fragmentation. The standard basal entropy can characterize the disintegrated particles of MGCM with different PU content under vertical loading and drying-wetting cycles. The standard basal entropy of GCM decreases rapidly initially and then stabilizes as the number of drying-wetting cycles increases. The standard basal entropy decreases exponentially as the vertical load increases. The results provide a new quantitative index for analyzing the grading characteristics of MGCM following disintegration, which are valuable for engineering construction and disaster prevention in carbonaceous mudstone areas.

Numerical study on rock fracturing with pulsed pressure in hard rocks with a pipe-domain seepage model

The disintegration process and the fracture propagation degree in rock masses under pulsed pressure are of great interest to the engineering community. This study presents a novel numerical simulation method for pulsed pressure-induced rock fractures based on the stress analysis in the elastic medium and the use of the boundary conditions with internal and external pressures. To enclose the particles, a method of constructing pipe network is proposed via the particle flow code (PFC2D) method, which facilitated the control of fluid flow and pressure by incremental pressure. This method was rooted in the pipe domain percolation approach and allowed for the understanding of the loading process and crack propagation mechanism through the laboratory experiments and engineering cases. The results demonstrated that the fracturing of rock mass under impulsive loading was a combined effect of stress waves and high-pressure fluids. The action of the stress wave induced initial cracks in the rock masses, while the fluid penetrated into these cracks, exerting pressure on the surrounding particles. This led to an increase in fracture width and an influx of more fluid, which enhanced the fracturing process. The fracture lengths induced by the fluid splitting action accounted for over 60 % of the total. The method provides a solid foundation for analyzing the mechanisms of pulsed pressure-induced rock fracturing and offers invaluable insights into predicting the degree of disintegration.

Visualization of the frequency effect of pulsed electric field on enzymatic browning of peel ground tissue

The enzymatic browning behavior of a model ground tissue, banana peel, influenced by the frequency variable of pulsed electric field (PEF), has been visualized and studied. The tissue was PEF-treated with 15 µs pulse at 3.3 kV/cm using trains of 5, 15, and 30 pulses, each varying from 0.1 Hz to 10 Hz; images and electrical conductivity were recorded intermittently throughout the incubation. The degree of browning was quantified with a browning index (BI) term, and the uniformity of browning was visually assessed by inspecting the pattern of pigment distribution. Moreover, the degree of tissue disintegration was calculated using a conductivity-based tissue disintegration index (DI) and compared to the BI and specific energy input. Browning uniformity was found to be significantly affected and increased with decreasing frequency. The effect was most noticeable up to disintegration degree of about 63, DI, or when the frequency of 5 or 15 pulses was reduced from 1 Hz to 0.1 Hz. Remarkably, the decrease at 5 pulses resulted in a significant increase in BI without a substantial increase in DI. The observed effect has been attributed to increased electrophoretic mobility of browning agents along the extracellular path during 0.1 Hz pulsation. Furthermore, lowering the frequency to 0.1 Hz reduced the energy required for a browning level close to saturation by about 57% compared to 10 Hz.

Dimedone nanoparticle as a promising approach against toxoplasmosis: In vitro and in vivo evaluation

Toxoplasma gondii, an intracellular parasite, has shown drug resistance and therapeutic failure in recent years. Dimedone (DIM) has been introduced as a new chemical compound with anti-bacterial and anti-cancer properties. The aim of this study was to investigate the potential protective role of DIM nanoparticles in an animal model of toxoplasmosis. Cytotoxicity of DIM on Vero cell line assessed using MTT, and the effect of DIM on Toxoplasma gondii was evaluated by counting the number of parasites compared to the control group in vitro. The rate of pathogenesis and virulence of the parasite was checked on the liver cells of the animal model using hematoxylin-eosin staining. Furthermore, various parameters indicating oxidative stress were compared in mouse liver tissue in different groups. The release of the nanoparticle form was significantly longer than the free drugs. The IC50 of Nano-DIM was 60 µM and the reduction of intracellular parasite proliferation in the group Nano-DIM and Nano-PYR (Nano-primethamine) was significantly lower than the free drugs in vitro. Histopathology examination in the groups treated with dimedone nanomedicine showed that the degree of disintegration of the epithelium of the central vein of the liver and infiltration and vacuolization of liver cells were lower compared to the toxoplasmosis group. Additionally, the level of some oxidative stress indicators was observed to be lower in the nano-treated groups compared to other groups. The results of this study showed DIM can be used as a promising compound for anti-T. gondii activity and can prevent the proliferation of it in cells.