Diseases Of Modern Civilization Research Articles

Research on the Application of the Dynamic Assisted Sleep Light to Smart Mobile Devices

With the rapid development of science and technology, social competition becomes more and more fierce, and work pressure becomes more and more intense. The problem of sleep has become a disease of modern civilization, and in order to alleviate sleep problems and improve sleep quality, related research methods are constantly updated, and there are more and more ways to address these problems. In this paper, we propose a dynamic assisted sleep light that adjusts the color temperature, illuminance, and frequency of change by controlling the backlight of the smart mobile device, so that the user experiences an improved quality of sleep. In this study, the methods of subjective questionnaire survey and non-subjective physiological parameter measurement were adopted for analysis. The results showed that the continuous use of the light source could continuously enhance the user’s delta energy during sleep and promote the improvement of sleep quality.

Altered Metabolome of Lipids and Amino Acids Species: A Source of Early Signature Biomarkers of T2DM.

Diabetes mellitus, a disease of modern civilization, is considered the major mainstay of mortalities around the globe. A great number of biochemical changes have been proposed to occur at metabolic levels between perturbed glucose, amino acid, and lipid metabolism to finally diagnoe diabetes mellitus. This window period, which varies from person to person, provides us with a unique opportunity for early detection, delaying, deferral and even prevention of diabetes. The early detection of hyperglycemia and dyslipidemia is based upon the detection and identification of biomarkers originating from perturbed glucose, amino acid, and lipid metabolism. The emerging “OMICS” technologies, such as metabolomics coupled with statistical and bioinformatics tools, proved to be quite useful to study changes in physiological and biochemical processes at the metabolic level prior to an eventual diagnosis of DM. Approximately 300–400 such metabolites have been reported in the literature and are considered as predicting or risk factor-reporting metabolic biomarkers for this metabolic disorder. Most of these metabolites belong to major classes of lipids, amino acids and glucose. Therefore, this review represents a snapshot of these perturbed plasma/serum/urinary metabolic biomarkers showing a significant correlation with the future onset of diabetes and providing a foundation for novel early diagnosis and monitoring the progress of metabolic syndrome at early symptomatic stages. As most metabolites also find their origin from gut microflora, metabolism and composition of gut microflora also vary between healthy and diabetic persons, so we also summarize the early changes in the gut microbiome which can be used for the early diagnosis of diabetes.

Evaluation of in-vitro antidiabetic activity of leaf juice of Plectranthus amboinicus (lour.)

Diabetes mellitus ‘the disease of modern civilization’ is characterized by chronic hyperglycaemia. The management of elevated post prandial glucose is critical to control the sequale of complications and α-amylase, α-glucosidases are responsible for elevated plasma glucose. Enzyme inhibitors in current clinical practice like acarbose, voglibose etc. are known to cause various gastrointestinal side effects. The present study was aimed to screen for potential α-amylase and α-glucosidase inhibitors from natural sources by in–vitro antidiabetic assays to overcome the side effects and toxicity. Different concentrations of leaf juice of Plectranthus amboinicus Lour. (20, 40, 60, 80 &100 μg/ml) were tested against fungal α-amylase and α-glucosidases isolated from albino rat small intestine and a prominent dose dependent inhibition of the enzymes was observed comparable with the marketed product, Acarbose. The IC50 values of LJPA and acarbose on fungal α-amylase was found to be 83.15 &52.15 μg/ml respectively. The IC50 values of LJPA and acarbose on α-glucosidase was found to be 92.44 &54.84 μg/ml respectively. The protein concentration of leaf juice was found to be 10.6 mg/ml.

Impedance Therapy in Rehabilitation of Degenerative Disc Disease Randomized Clinical Trial

Aim: The aim of this work is to investigate the effects of Impedance Therapy (IT) in the treatment of degenerative disc disease by confirming the presence of the "disc grow-up" (DGU) phenomenon. Method: The set consisted of 55 patients with DDD with an average age of 51.3 years divided into two groups – the experimental group and control group. The experimental group consisted of 29 patients with an average age of 56.7 years. The control group consisted of 26 patients with an average age of 45.8 years. Results: In the experimental group of patients with DDD, who received IT, the DGU phenomenon with a success rate of 76% was observed, with an average increase in the volume of the intervertebral disc of 31% (p <0.000). In the control group of patients receiving standard electrotherapy, the DGU phenomenon was not proven – the DDD progressed normally with a mean volume reduction of 15% (p <0.000). Conclusions: Degenerative disc disease as a disease of modern civilization is treatable. It can be concluded that the theory, that degenerative disc changes are irreversible has been overcome by the impact of impedance therapy.

Possible synergistic effect of apoE and LRP1 genotypes on metabolic syndrome development in Serbian patients

The modern way of life contributes to the higher frequency of a complex state medically called metabolic syndrome (MetS), which is an inevitable consequence of several most common diseases of modern civilization. Patients with MetS have three times higher risk of experiencing a heart attack or a stroke and twice higher possibility to die from them. Serbia holds the infamous third place in Europe in mortality from heart disease, just behind Russia and Ukraine. The study explores the correlation of every combination of genotypes of apoE (apolipoprotein E) and LRP1 (low density receptor- related protein 1) genes with presence of MetS, and the connection with each anthropometric and biochemical parameter in both tested groups. Study demonstrates the impact of genotype combinations on the emergence and development of the MetS in Serbia. 63 patients and 30 controls were included in the study, aged from 19 to 65. Each person genotype was determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) profile. Odds ratio (OR) values showed that the presence of apoE e3e4/LRP1 CC genotype combination of genotypes in patients multiplies the chance (7.6 times) for the occurrence of the MetS in comparison to the presence of other genotype combinations. Determining the genetic basis of MetS is one of the necessary steps in the prevention of disease, saving the cost of treatment, and in the design of targeted therapies.

Efficiency and predictive parameters of outcome of a multimodal pain management concept with spinal injections in patients with low back pain: a retrospective study of 445 patients.

Low back pain is one of the most common diseases of modern civilization. Multimodal pain management (MPM) represents a central approach to avoiding surgery. Short-term results are published rarely and often incomparable because of different treatment concepts. This study compared the subjective and objective parameters as well as the anamnestic and clinical parameters of 445 patients with low back pain before and after inpatient MPM to investigate the influence of this type of therapy on short-term outcome. The majority of patients were very satisfied (39%) or satisfied (58%) with the treatment outcome. The median pain reduction for back pain was 3.0 (IQR 2.88) (numeric rating scale, NRS), thus 66% and 2.75 (IQR 3.38, 62%) for leg pain. The main pain reduction occurred within the first 10 days of treatment and was clinically significant from day 5 onwards. The outcome for patients with hospitalization of more than 10days was significantly worse. The parameters female sex, BMI of > 30, local pain, and pain duration of 3-24months had a significantly better outcome. In contrast, age, treatment cause, depression, anxiety, and other diseases had no statistically significant influence on outcome. MPM therapy for more than 5days seems to be an efficient short-term approach to treating low back pain. Knowledge of some of the outcome predictors helps to early identify patients who require more intensive individual care. In the case of no clear indication for surgery, MPM can be an appropriate treatment option.

Advances in exploring the role of microRNAs in the pathogenesis, diagnosis and therapy of cardiac diseases in China.

Cardiovascular disease has become the most serious health threat and represents the major cause of morbidity and mortality in China, as in other industrialized nations. During the past few decades, China's economic boom has tremendously improved people's standard of living but has also changed their lifestyle, increasing the prevalence of cardiovascular disease, the so-called 'disease of modern civilization'. This new trend has attracted a significant amount of research. Many of the studies conducted by Chinese investigators are orientated towards understanding the molecular mechanisms of cardiovascular disease. At the molecular level, the long-standing consensus is that cardiovascular disease is associated with a sequence mutation (genetic anomaly) and expression deregulation (epigenetic disorder) of protein-coding genes. However, new research data have established the non-protein-coding genes microRNAs (miRNAs) as a central regulator of the pathogenesis of cardiac disease and a potential new therapeutic target for cardiovascular disease. These small non-coding RNAs have also been subjected to extensive, rigorous investigations by Chinese researchers. Over the years, a large body of studies on miRNAs in cardiovascular disease has been conducted by Chinese investigators, yielding fruitful research results and a better understanding of miRNAs as a new level of molecular mechanisms for the pathogenesis of cardiac disease. In this review, we briefly summarize the current status of research in the field of miRNAs and cardiovascular disease in China, highlighting the advances made in elucidating the role of miRNAs in various cardiac conditions, including cardiac arrhythmia, myocardial ischaemia, cardiac hypertrophy and heart failure. We have also examined the potential of miRNAs as novel diagnostic biomarkers and therapeutic targets.

Medicinal mushroom for prevention of disease of modern civilization.

Medicinal mushroom for prevention of disease of modern civilization.

Evaluation Of Antioxidant Defense In Patients With Colorectal Carcinoma.

Cancers are among the most feared diseases of modern civilization. In Poland, colorectal cancer is one of the tumors with the worst prognosis. The ability to cure is primarily dependent on the stage of the disease at the time of diagnosis. The aim of the study was evaluate antioxidant response in patients with colorectal carcinoma. Twenty patients (14 men and 6 women) aged 61.9± 11.1 years with colorectal cancer were included in the study. Twenty healthy subjects (4 men and 16 women) aged 64 ± 15.3 years formed the control group. The erythrocyte activities of antioxidant enzymes, superoxide dismutase (SOD), and glutathione peroxidase (GPx), Results. A significant increase of GPx, and SOD (p < 0.05) were seen in patients compared to healthy controls. The results indicate that the tested antioxidant enzyme activity of glutathione peroxidase and superoxide dismutase is increased in patients diagnosed with colorectal cancer compared to the control group.

Is Postpartum Depression a Disease of Modern Civilization?

Access to calorie-dense foods, medicine, and other comforts has made modern humans healthier than our prehistoric ancestors in many respects. However, the epidemics of obesity, diabetes, and cardiovascular disease suggest that there are also drawbacks to modern living. Here, we address the question of whether the dramatic cultural changes that have occurred over the past century have inflated rates of postpartum depression, adding postpartum depression to the list of “diseases of modern civilization.” We review evidence from cross-cultural, epidemiological, and experimental studies documenting associations between postpartum depression and modern patterns of early weaning, diets deficient in essential fatty acids, low levels of physical activity, low levels of sun exposure, and isolation from kin support networks, all of which mark significant divergences from lifestyles believed to have been typical throughout human evolutionary history. This “mismatch hypothesis” of postpartum depression integrates research across diverse research areas and generates novel predictions.

Możliwości kształtowania postaw zdrowotnych dzieci i młodzieży w Polsce

Lifestyle, environment, genetics and usage of health care are the classical health determinants. Each of these factors influences personal health to certain degree. Lifestyle has the biggest impact (50–52%), followed by environment (18–20%), genes (15–20%) and finally usage of health care (10–15%). Acknowledgement of negative health behaviours as key reason for diseases of modern civilization formed the basis for many preventive actions. Implementation of preventive health programs is aimed at shaping healthy lifestyle and healthy behaviours in society. The objective of this article is to present links between social marketing and possibilities to influence healthy behaviours of kids and youth. Necessity for holistic approach to health and examples of healthy behaviours of kids and young people in Poland are discussed.

Milk and Acid-Base Balance: Proposed Hypothesis versus Scientific Evidence

Recently the lay press has claimed a hypothetical association among dairy product consumption, generation of dietary acid, and harm to human health. This theoretical association is based on the idea that the protein and phosphate in milk and dairy products make them acid-producing foods, which cause our bodies to become acidified, promoting diseases of modern civilization. Some authors have suggested that dairy products are not helpful and perhaps detrimental to bone health because higher osteoporotic fracture incidence is observed in countries with higher dairy product consumption. However, scientific evidence does not support any of these claims. Milk and dairy products neither produce acid upon metabolism nor cause metabolic acidosis, and systemic pH is not influenced by diet. Observations of higher dairy product intake in countries with prevalent osteoporosis do not hold when urban environments are compared, likely due to physical labor in rural locations. Milk and other dairy products continue to be a good source of dietary protein and other nutrients.Key teaching points: • Measurement of an acidic pH urine does not reflect metabolic acidosis or an adverse health condition.• The modern diet, and dairy product consumption, does not make the body acidic.• Alkaline diets alter urine pH but do not change systemic pH.• Net acid excretion is not an important influence of calcium metabolism.• Milk is not acid producing.• Dietary phosphate does not have a negative impact on calcium metabolism, which is contrary to the acid-ash hypothesis.

Traditional Non‐Western Diets

In traditional cultures, balancing health with a balanced lifestyle was a core belief. The diseases of modern civilization were rare. Indigenous people have patterns of illness very different from Western civilization; yet, they rapidly develop diseases once exposed to Western foods and lifestyles. Food and medicine were interwoven. All cultures used special or functional foods to prevent disease. Food could be used at different times either as food or medicine. Foods, cultivation, and cooking methods maximized community health and well-being. With methods passed down through generations, cooking processes were utilized that enhanced mineral and nutrient bioavailability. This article focuses on what researchers observed about the food traditions of indigenous people, their disease patterns, the use of specific foods, and the environmental factors that affect people who still eat traditional foods.

Paleolithic Nutrition

A quarter century has passed since the first publication of the evolutionary discordance hypothesis, according to which departures from the nutrition and activity patterns of our hunter-gatherer ancestors have contributed greatly and in specifically definable ways to the endemic chronic diseases of modern civilization. Refinements of the model have changed it in some respects, but anthropological evidence continues to indicate that ancestral human diets prevalent during our evolution were characterized by much lower levels of refined carbohydrates and sodium, much higher levels of fiber and protein, and comparable levels of fat (primarily unsaturated fat) and cholesterol. Physical activity levels were also much higher than current levels, resulting in higher energy throughput. We said at the outset that such evidence could only suggest testable hypotheses and that recommendations must ultimately rest on more conventional epidemiological, clinical, and laboratory studies. Such studies have multiplied and have supported many aspects of our model, to the extent that in some respects, official recommendations today have targets closer to those prevalent among hunter-gatherers than did comparable recommendations 25 years ago. Furthermore, doubts have been raised about the necessity for very low levels of protein, fat, and cholesterol intake common in official recommendations. Most impressively, randomized controlled trials have begun to confirm the value of hunter-gatherer diets in some high-risk groups, even as compared with routinely recommended diets. Much more research needs to be done, but the past quarter century has proven the interest and heuristic value, if not yet the ultimate validity, of the model.

Biobanks and Legislation in Switzerland – a data protection perspective

AbstractThe combination of health and lifestyle data with bodily substances and genetic information has led over the last few years to the creation of so-called biobanks. These biobanks are used to research a large number of diseases of modern civilization and their genetic interactions. One of the best-known projects in this respect is without a doubt the Icelandic biobank, operated since 1998 by a private pharmaceutical company, deCode Genetics, and set up with government support. The database contains family histories and medical records, as well as biological samples taken from a large section of Iceland's homogeneous population. The hope is that this data will allow a correlation to be established between genetic predispositions and the onset of widespread diseases. Other examples of population-based biobanks include the Estonian Genome Project, launched in 2001 by the Estonian Government, as well as the UK Biobank in the UK and PopGen in the state of Schleswig-Holstein in Germany.

Meat: From functional food to diseases of modern civilization

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Human nutrition and food research: opportunities and challenges in the post-genomic era.

Sequencing of the human genome has opened the door to the most exciting new era for nutritional science. It is now possible to study the underlying mechanisms for diet-health relationships, and in the near future dietary advice (and possibly tailored food products) for promoting optimal health could be provided on an individual basis, in relation to genotype and lifestyle. The role of food in human evolution is briefly reviewed, from palaeolithic times to modern-day hunter-gatherer societies. The aetiology of 'diseases of modern civilization', such as diabetes, heart disease and cancer, and the effect of changes in dietary patterns are discussed. The risk of disease is often associated with common single nucleotide polymorphisms, but the effect is dependent on dietary intake and nutritional status, and is often more apparent in intervention studies employing a metabolic challenge. To understand the link between diet and health, nutritional research must cover a broad range of areas, from molecular to whole body studies, and is an excellent example of integrative biology, requiring a systems biology approach. The annual cost to the National Health Service of diet-related diseases is estimated to be in excess of 15 billion, and although diet is a key component of any preventative strategy, it is not given the prominence it deserves. For example, less than 1% of the pound 1.6 billion budget for coronary heart disease is spent on prevention. The polygenic and multifactorial nature of chronic diseases requires substantial resources but the potential rewards, in terms of quality of life and economics, are enormous. It is timely therefore to consider investing in a long-term coordinated national programme for nutrition research, combining nutritional genomics with established approaches, to improve the health of individuals and of the nation.

ACP1 and human adaptability: association with past malarial morbidity in the Sardinian population.

Acid Phosphatase locus 1 (ACP1) is a polymorphic enzyme controlled by a locus on chromosome 2 with three common codominant alleles: *A, *B, and *C. ACP1 shows two major isoforms, F and S. The ratio of their concentration differs markedly among genotypes. Two functions have been proposed for the enzyme: flavin-mononucleotide phosphatase and tyrosine phosphatase activity. An association between ACP1 polymorphism and past malarial morbidity in Sardinia and the Po Valley has been described. Genetic polymorphisms could contribute to natural resistance or susceptibility to the disease. On the other hand, malaria pressure may select for genes that increase susceptibility to common diseases of modern civilization. Thus, the association between ACP1 and malaria in Sardinia in the light of recent understanding of the function of ACP1 and the molecular basis of malaria pathophysiology, especially aspects of the structure of band 3 protein (B3P) and the role of cytokines have been revisited. There is a significant negative correlation between ACP1 S isoform concentration, directly related to the ACP1*C allele, and past malarial morbidity in Sardinia. Populations subjected in the past to a heavy malarial burden show, at present, a lower concentration of the S isoform compared to a nearby malaria-free population, suggesting that genotypes with high S isoform concentration have been subjected to negative selection in a malarial environment. Correlation analysis and analysis of the joint G-6-PD/ACP1 distribution suggest that the relationship between past endemic malaria and the S isoform has not been mediated by glucose-6-phosphate dehydrogenase (G-6-PD) deficiency, thus pointing to a direct effect of malaria on ACP1.

Uncomplicated Diverticulitis: Indications for Surgery and Surgical Management

Diverticulosis is a disease of modern civilization. Complications may develop, the most common being acute diverticulitis. Repeated attacks, particularly those requiring hospitalization, strongly suggest the need for elective surgical resection of the involved colon. Young persons and patients who are immunocompromised require a particularly aggressive surgical approach. Elective resection is considerably safer than emergency operation. Defining which persons will benefit from surgical therapy is the goal to minimize the morbidity and mortality associated with this common colonic disorder.

The relation of physical activity and occupation to coronary artery heart disease.

Article1 November 1954THE RELATION OF PHYSICAL ACTIVITY AND OCCUPATION TO CORONARY ARTERY HEART DISEASEJOSEPH G. BENTON, Ph.D., M.D., HOWARD A. RUSK, M.D., F.A.C.P.JOSEPH G. BENTON, Ph.D., M.D.Search for more papers by this author, HOWARD A. RUSK, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-41-5-910 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONIt has been suggested that there has been an increased incidence of coronary artery heart disease in recent years. This disease of modern civilization has assumed prominence during a period in which heavy labor is less common and length of work hours has decreased; while other pressures have increased. Constitutional factors are important in coronary artery heart disease, but there is also evidence of variation of its incidence with environment. 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Y.*Presented as a Morning Lecture at the Thirty-fifth Annual Session of the American College of Physicians, Chicago, Illinois, April 7, 1954.From the Department of Physical Medicine and Rehabilitation and the Institute of Physical Medicine and Rehabilitation, New York University-Bellevue Medical Center, New York, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFormation of New Cardiomyocytes in ExercisePlasma cholesterol and phospholipids in various occupational groupsSome behavioural and other correlates of cholesterol metabolismCardiac adrenergic preponderance due to lack of physical exercise and its pathogenic implications∗Coronary heart diseaseThe physique of bus and truck drivers: With a review of occupational anthropology 1 November 1954Volume 41, Issue 5Page: 910-917KeywordsCoronary arteriesCoronary artery heart diseaseExerciseRehabilitation medicine ePublished: 1 December 2008 Issue Published: 1 November 1954 PDF downloadLoading ...