During his adult life Vincent wrote more than 700 letters, mostly to his brother, Theo. Early in this correspondence he said to Theo, “Do you want me to continue writing about everything the way I have lately, telling you the thoughts that come into my mind without being afraid of letting myself go, without keeping back my thoughts or censoring them?” (15, Letter 169). These letters, written before the discovery of psychoanalysis, constitute an act of self-revelation comparable in many ways to that of the modern psychoanalytic patient. The detailed introspective data contained in them provide a unique opportunity for understanding the syndrome of episodic behavioral disorders. They suggest, in particular, how Vincent's episodic psychoses both interfered with and augmented his unique creativity. It is proposed that bursts of electrical activity within the limbic system are associated with an inspirational thought (an experience often referred to as a “brainstorm”) or a new perception of the world similar to the psychedelic experience induced by hallucinogens. If more prolonged, the behavior becomes maladaptive and includes self-defeating impulses (dyscontrol action). If still more persistent, there occurs an episodic psychotic reaction accompanied by overwhelming painful emotions, hallucinations, delusions, and confusion with a consequent loss of personal identity. This is a frightening interruption of one's life style or life flow. Vincent's letters dramatize all of these stages of limbic “seizural” activity. Such bursts of seizural activity within the limbic system can be induced not only by psychological stress but also metabolic disequilibrium, external toxins, such as alcohol, and pertinent for Vincent's situation, a convulsive constituent of absinthe (thujone). Thus, psychological and neurophysiological mechanisms are complementary and not contradictory. It is proposed that for Vincent, Limbic system sensitivity, physical neglect, absinthe abuse, and repeated psychological stress, as well as strength of character, creative temperament, innate artistic ability, and disciplined development of his artistic skills provided a rare combination of coincidences which in part explains why Vincent's life was a shambles and his artistic creativity unique.