Soon after the discovery of neutrons by J. Chadwick in 1932, a major project was undertaken in the Physics Depar tment of the University of R o m e in which every immediately available element in the Periodic Table was irradiated with neutrons from a strong radium-beryl l ium source. The artificial radioactivity was detected in most of the cases, and the half lives reported. The chemical behaviour of the induced radioactivity was also reported, and it was pointed out that the active elements generated were often chemically different from the bombarded elements. A long paper by E. Fermi et al. At was communicated by Lord Rutherford in the Proceedings of The Royal Society, received on 25 July 1934. Six months later a second paper A2 followed, in which the effect of hydrogenous material in greatly enhancing the activation effects was reported, and attributed to the slowing down of neutrons by light a tom collisions. This was published by the same authors, with B. Pontecorvo added, in February 1935. In between these two papers the short note which is included as the first Source Paper was published in September 1934 in Nature A3. Working in the Physics Depar tment of the Medical College of St Bar tholomew's Hospital in London, Szilard and Chalmers described the separation of radioactive iodine, which they called 'free ' iodine, by the bombardment of its parent iodine in liquid ethyl iodide with neutrons from a radon-beryl l ium source. As a result of this work, the effect by which a nuclear t ransformation releases the radioactive a tom from its parent molecule has been called ' the Szi lard-Chalmers Effect'. In this first paper they note that the effect only occurs when there is no chemical interchange between the free element and its parent compound. Following the pioneer experiment of Fermi, it has been found by Fermi, Amaldi, D'Agostino, Rasetti and Segr(~ that many elements up to the atomic number 30, when bombarded by neutrons from a radon-beryllium source, are transmuted into a radioactive element which is chemically different from the bombarded element. In several cases of this type, they succeeded in separating chemically the active substance from the bulk of the bombarded element, and there is no inherent difficulty in getting any desirable concentration of the radioactive element. They have not observed such chemical changes in elements above the atomic number 30, though many of these heavier elements show strong Fermi effects. For some of these, for example, arsenic, bromine, iodine, iridium and gold, they could show that the activity is carried by the bombarded element, which in the circumstances leads to the conclusion that the radioactive element is an isotope of the bombarded element. In order to separate the radioactive isotope of the bombarded element from the bulk of the bombarded element, one has to find a new principle of separation. We have attempted to apply the following principle. If we irradiate by a neutron source a chemical compound of the element in which we are interested, we might expect those atoms of the element which are struck by a neutron to be removed from the compound. Whether the atoms freed in this way will interchange with their isotopes bound in the irradiated chemical compound will depend on the nature of the chemical compound with which we have to deal. If we work under conditions in which such an interchange does not take place, we obtain the radioactive isotope 'free' and by separating the 'free' element from the compound we can obtain any desirable concentration of the radioactive isotope. We have applied this principle to iodine. Ethyl iodide has been irradiated and a trace of free iodide added to protect the radioactive isotope. By reduction and precipitation as silver iodide in water, it was easy to concentrate the activity so as to get from the precipitate 10 times as many impulses of the Geiger-MiJller /3-ray counter as directly from the irradiated ethyl iodide z. Apparently a large fraction of the active substance could be extracted from the ethyl iodide. The quantity of the active element obtainable in the precipitate will naturally depend on the quantity of the compound subjected to irradiation. This principle of isotopic separation has also been applied to some other elements which, like iodine, are
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