ABSTRACT This research investigates the interplay of witchcraft beliefs, epilepsy, poverty, stigma, and discrimination in Nigerian Yoruba Pentecostal communities. Through semi-structured interviews with 15 Yoruba Pentecostal leaders in southwestern Nigeria and engaging with scholarly works on religion, health, and disability in Africa, this study provides nuanced insights into the complex intersections of these topics. Highlighting the significant role of practical theology, the paper argues for its potential in fostering more inclusive communities. A key element of this article is that it illustrates how theological practices can cultivate respect and understanding for individuals with epilepsy and challenge prevailing cultural beliefs and medical misconceptions. Taking this approach is crucial to dismantling the stigmas and discrimination prevalent in these communities. A major outcome of the study is the recommendation of effective strategies to increase epilepsy awareness and foster empathy within Yoruba Pentecostal circles, promoting social inclusion and transforming attitudes towards health and disability in African religious contexts. Overall, this research contributes to the broader dialogue on religion, health, and social inclusion in Africa, emphasising the transformative power of practical theology in addressing critical social issues.