The present study evaluates selected morphometric characteristics of 39 direct tributaries of the Buzău River (area of 4112 km2) to prioritize development actions in these sub-watersheds, which are distributed in three geographical regions within the full Buzău River watershed: the Carpathian, Subcarpathian, and plains regions. By combining a variable number of morphometric parameters, using various mathematical models, we can evaluate the state of balance or imbalance in a watershed and identify sub-watersheds vulnerable to natural processes. Prioritization was achieved using composite (Cp) values by comparing two scenarios. In the first scenario, 11 derived morphometric parameters were used, and in the second scenario, another 7 parameters were added. The obtained values were grouped into five classes (very high, high, medium, low, and very low). Due to the heterogeneity of relief units among geographical regions, there are classification differences for sub-watersheds among those regions. Watersheds classed as very high priority for intervention actions are located in the Carpathian (SW1, SW2, SW15, SW16) and Subcarpathian areas (SW24, SW30), which are characterized by high relief energy and pronounced slope instability, which leads to an increase in the risk of flooding and land degradation. For comparison, all sub-watersheds in the plains region, are classified as very low or low priority. Since the arithmetic mean is sensitive to extreme values, its use in the calculation of composite (Cp) values causes the values to be “eclipsed” and the sub-watersheds to be placed in different prioritization classes (SW18 and SW34), depending on the analyzed scenario, due to the large number of parameters and classified sub-watersheds.