Using generalized factorization theorems, we calculate the leading single transverse spin asymmetry for high transverse-momentum direct-photon production in pp collisions, in terms of partonic matrix elements. The leading contribution comes from a ``twist-3'' parton distribution, involving the correlation between quark fields and the gluonic field strength. With simple assumptions for this matrix element, the asymmetry increases with ${\mathit{x}}_{\mathit{F}}$, naturally giving effects of 10% or more at large ${\mathit{x}}_{\mathit{F}}$.
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