Direct N-Alkylation Of Amines Research Articles

A reusable MOF supported single-site nickel-catalyzed direct N-alkylation of anilines with alcohols

The direct N-alkylation of amines with alcohols is an efficient route through a borrowing hydrogen (BH) strategy. Herein, a highly selective, and reusable Ni(II)-bipyridine-based metal-organic framework (MOF) catalyst was designed for this organic transformation. This earth-abundant metal-based metal-organic framework (MOF) catalyst significantly outperform their homogeneous analogues and the immobilized catalyst was reusable for at least up to 4 cycles without significant decrease in the yield of the target product.

Direct N-alkylation of amines with alcohols using AlCl3 as a Lewis acid

Abstract A substitution reaction of amines with alcohols for N-alkylated amines has been developed using inexpensive AlCl3 without any ligand or additive. Either aromatic or aliphatic amines and primary or secondary alcohols perform the AlCl3-mediated reaction smoothly to afford various N-alkylated amines in satisfactory yields.

N-Alkylation of amines with alcohols over nanosized zeolite beta

Direct N-alkylation of amines with alcohols was successfully performed by using nanosized zeolite beta, which showed the highest catalytic activity among other conventional zeolites. This method has several advantages, such as eco-friendliness, moderate to high yields, and simple work-up procedure. The catalyst was successfully recovered and reused without significant loss of activity and only water is produced as co-product. In addition, imines were also efficiently prepared from the tandem reactions of amines with 2-, 3- and 4-nitrobenzyl alcohols using nanosized zeolite beta.