Recommender System provides users with online services in a personalized way. The performance of traditional recommender systems may deteriorate because of problems such as cold-start and data sparsity. Cross-domain Recommendation System utilizes the richer information from auxiliary domains to guide the task in the target domain. However, direct knowledge transfer may lead to a negative impact due to data heterogeneity and feature mismatch between domains. In this article, we innovatively explore the cross-domain correlation from the perspectives of content semanticity and structural connectivity to fully exploit the information of Knowledge Graph. First, we adopt domain adaptation that automatically extracts transferable features to capture cross-domain semantic relations. Second, we devise a knowledge-aware graph neural network to explicitly model the high-order connectivity across domains. Third, we develop feature fusion strategies to combine the advantages of semantic and structural information. By simulating the cold-start scenario on two real-world datasets, the experimental results show that our proposed method has superior performance in accuracy and diversity compared with the SOTA methods. It demonstrates that our method can accurately predict users’ expressed preferences while exploring their potential diverse interests.