The dynamic fluctuations in the atmospheric refractive index, commonly referred to as optical turbulence, cause phase distortions of the electromagnetic waves propagating through the atmosphere. The consequent scintillations have large implications for free-space optical communication, laser remote sensing, and directed energy applications. The refractive index structure parameter (C n 2), quantifying the strength of these fluctuations, is usually estimated using high-frequency micrometeorological measurements, employing sonic anemometer-thermometers or scintillometers. Despite providing highly accurate information, these systems are immensely complex and costly, especially for frequent field applications and remote locations. In this study, we have developed an empirical multinomial model for estimating C n 2 using three-year macrometeorological data and validated it against collocated and concurrent micrometeorological measurements, from a tropical semi-arid location. This simpler model would be handy for applications in remote locations having weather station measurements alone.