Direct Comparison Research Articles

Logging out or leaning in? Social media strategies for enhancing well-being.

Social media use is endemic among emerging adults, raising concerns that this trend may harm users. We tested whether reducing the quantity of social media use, relative to improving the way users engage with social media, benefits psychological well-being. Participants were 393 social media users (ages 17-29) in Canada, with elevated psychopathology symptoms, who perceived social media to negatively impact their life somewhat. They were randomized to either (a) assistance to engage with social media in a way to enhance connectedness (tutorial), (b) encouragement to abstain from social media (abstinence), or (c) no instructions to change behavior (control). Participants' social media behaviors were self-reported and tracked using phone screen time apps while well-being was self-reported, over four timepoints (6 weeks in total). Results suggested that the tutorial and abstinence groups, relative to control, reduced their quantity of social media use and the amount of social comparisons they made on social media, with abstinence being the most effective. Tutorial was the only condition to reduce participants' fear of missing out and loneliness, and abstinence was the only condition to reduce internalizing symptoms, relative to control. No condition differences emerged in eating pathology or the tendency to make social comparisons in an upward direction. Changes in social media behaviors mediated the effects of abstinence (but not of tutorial) on well-being outcomes. Participant engagement and perceptions of helpfulness were acceptable, but the abstinence group possibly perceived the content as less helpful. In conclusion, using social media differently and abstaining from social media may each benefit well-being. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Að þjóna sömu herrum en keppa þó: Sameiginlegt eignarhald á íslenskum hlutabréfamarkaði

Tilgangur þessarar greinar er að fjalla um og varpa ljósi á sameiginlegt eignarhald fyrirtækja á skráðum hlutabréfamarkaði á Íslandi og er það borið saman við umfang slíks eignarhalds í Bandaríkjunum. Nokkur umræða hefur verið um hversu fáir aðilar eiga stóra hluti í íslenskum fyrirtækjum sem eru í samkeppni við hvert annað og því er umfang þessa og þróun á íslenskum hlutabréfamarkaði greind. Sjónum er beint að þremur mörkuðum hér á landi þar sem tveir eða þrír keppinautar eru skráðir í Kauphöll Íslands. Það eru trygginga-, fjarskipta, og fasteignamarkaðir. Þá er umfang fjárfestinga lífeyrissjóða á íslenskum hlutabréfamarkaði greint á fjórum mismunandi tímapunktum; árin 2003, 2007, 2014 og 2016. Þótt erfitt sé að bera saman hlutabréfaeign milli tímabila sést að sameiginlegt eignarhald var mun minna fyrir efnahagshrunið árið 2008 en á árunum eftir hrun, bæði hjá öllum stærstu hluthöfum skráðra fyrirtækja og þá einkum lífeyrissjóðum. Um mitt ár 2016 var eign lífeyrissjóða í skráðum hlutafélögum í Kauphöll Íslands orðin umtalsverð eða um 50% af markaðsvirði allra skráðra félaga. Stærstu lífeyrissjóðirnir áttu hlut í nánast öllum hlutafélögum í kauphöllinni. Á þeim mörkuðum sem hér er fjallað um fara lífeyrissjóðirnir með yfir 45% eign í öllum skráðum fasteignafélögum, yfir 35% í öllum skráðum tryggingafélögum og yfir 50% í fjarskiptafyrirtækjum á markaði. Ekki liggur fyrir hvaða afleiðingar þetta sameiginlega eignarhald á íslenskum fyrirtækjum hefur á samkeppni og verð. Engar rannsóknir hafa enn verið gerðar á því. Bandarískar rannsóknir benda þó til þess að slíkt eignarhald hafi skaðleg áhrif á samkeppni. Í ljósi umfangs þess á Íslandi er ástæða til þess að greina áhrif þess hér og mun greinin því varpa betra ljósi á hvernig þróunin hefur verið á Íslandi síðustu tæpu tvo áratugi.

Comparing the clinical utility of the alternative model for personality disorders to the Section II personality disorder model: A randomized controlled trial.

The alternative model for personality disorders (AMPD) has been extensively studied over the past decade, but to date there is no direct comparison of the clinical utility of the AMPD model relative to the Section II personality disorder (PD) model in an ecologically valid design. The current study examined the clinical utility of an AMPD-informed assessment procedure and Section II PD assessment procedure as assessed by both patients and clinicians in a randomized controlled trial. A sample of 119 patients were randomly assigned to either an AMPD or a Section II PD assessment procedure. At the end of the assessment, patients filled out questionnaires pertaining to clinical utility, satisfaction, motivation for treatment, and general experience of the assessment. Clinicians who subsequently started treatment with these patients also completed two clinical utility questionnaires. There were no significant differences between the AMPD and Section II PD assessment procedure on patients' reported clinical utility, motivation for treatment, satisfaction, and general experience of the assessment nor were there significant differences between the models on clinician reported clinical utility. Explorative analyses revealed that, for patients, a positive relationship with the assessor was predictive of experienced utility. This study shows no superiority of the AMPD in terms of clinical utility but suggests that the alliance with the assessor is a particularly salient factor in clinical utility. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Analytical and clinical validation of an LC-MS/MS method for carbamazepine, lamotrigine and levetiracetam in dried blood spots

ObjectivesTherapeutic drug monitoring is performed routinely in patients on anti-epileptic drugs (AEDs) for optimisation and individualisation of therapy. The dried blood spot (DBS) sampling technique is a suitable, more patient-friendly...

Cross-species imputation and comparison of single-cell transcriptomic profiles.

Cross-species comparison and prediction of gene expression profiles are important to understand regulatory changes during evolution and to transfer knowledge learned from model organisms to humans. Single-cell RNA-seq (scRNA-seq) profiles enable us to capture gene expression profiles with respect to variations among individual cells; however, cross-species comparison of scRNA-seq profiles is challenging because of data sparsity, batch effects, and the lack of one-to-one cell matching across species. Moreover, single-cell profiles are challenging to obtain in certain biological contexts, limiting the scope of hypothesis generation. Here we developed Icebear, a neural network framework that decomposes single-cell measurements into factors representing cell identity, species, and batch factors. Icebear enables accurate prediction of single-cell gene expression profiles across species, thereby providing high-resolution cell type and disease profiles in under-characterized contexts. Icebear also facilitates direct cross-species comparison of single-cell expression profiles for conserved genes that are located on the X chromosome in eutherian mammals but on autosomes in chicken. This comparison, for the first time, revealed evolutionary and diverse adaptations of X-chromosome upregulation in mammals.

Intrapleural Thrombolytics for Parapneumonic Effusion: A Network Metaanalysis.

Intrapleural thrombolytics have been trialed for facilitating pleural fluid drainage in patients with complicated parapneumonic effusion. The present study is a network metaanalysis of randomized clinical trials (RCTs) that have evaluated these thrombolytics. Electronic databases (Medline, Cochrane CENTRAL, and Google Scholar) were searched for appropriate RCTs evaluating the therapeutic effect of thrombolytics in patients with complicated parapneumonic effusion. Mortality, the proportion of patients referred for surgical intervention, and serious adverse events were the outcome measures. Random-effects model was used for generating direct and mixed treatment comparison pooled estimates. Grading of the evidence for key comparisons was carried out. Odds ratio with 95% confidence intervals was used to represent the pooled estimates. Seventy-six studies were retrieved with the search strategy, of which 16 were included. No significant differences were observed in mortality. Compared to normal saline, significantly less proportion of patients was referred for surgical intervention with streptokinase (0.4, 0.2 to 0.8), urokinase (0.4, 0.2 to 0.8), alteplase (0.3, 0.1 to 0.7), and alteplase + DNase (0.2, 0.1 to 0.7). DNase alone increased the risk of referral to surgical intervention (3.4, 1.5 to 7.6). Only streptokinase was observed with an increased risk of serious adverse events compared to normal saline (2.8, 1.1 to 7.1) and alteplase (6.7, 1.1 to 39.9). Moderate quality of evidence was observed for streptokinase with normal saline for the proportion of patients referred for surgical intervention, while either low or very low quality strength was observed for all other comparisons. Streptokinase, urokinase, alteplase, and alteplase + DNase were observed in patients referred for surgical interventions when used intrapleural in patients with parapneumonic effusion. Alteplase + DNase is likely to outperform others as it was observed with the least risk of patients referred for surgical interventions. Until additional data emerges that changes the pooled estimates, thrombolytics other than streptokinase are preferred due to the increased risk of serious adverse events.

Influence of two paraffin wax chewing gums with different con-sistencies on the stimulated salivary flow rate.

This study investigated and compared the consistency and compressive strength of two commercially available paraffin wax chewing gums (Aurosan (AU) and GC Europe (GC)), as well as their impact on stimulated salivary flow rate. Instrumental texture analysis was uti-lized to assess the consistency and compressive strength of AU and GC during a 7-min chewing period. Subsequently, stimulated salivary flow rate (sSFR) was evaluated in healthy subjects using AU and GC over a 7-minute period. The compressive strengths from the pre-liminary test were compared over time with the sialometry data. Eighty-one test subjects, comprising 33 men and 48 women, participated. Over the 7-min measurement period, dif-ferences were observed in the total amount of saliva accumulated per minute. Direct com-parison of AU and GC revealed that regardless of age and gender, the amount of saliva formed after 1 min was 0.63 times less with AU than with GC (95% CI: 0.56 - 0.70; P < 0.001). The accumulated saliva volume with AU was also significantly lower than that with GC in the first 4 min (P = 0.016). However, from minute 5 onwards, the two products no longer showed statistical differences in the total amount of saliva. Comparison of the com-pressive strength of AU and GC showed that the values after 1 and 2 min were significantly higher for AU than for GC (P < 0.05); for all other time points, the compressive strength was higher for GC. In the mixed-effects model after log-transformation of compressive strength and saliva volume, GC exhibited decreasing saliva volumes with increasing compressive strength (P <0.001). Conversely, the opposite was observed for AU (P = 0.019). The study suggests that the consistency or compressive strength of paraffin wax chewing gums from different manufacturers could impact sSFR.

Late Paleozoic Remagnetization on the Western Slope of the Southern Urals: Age and Geotectonic Implications

The paper presents the results of paleomagnetic studies on numerous intrusive bodies of the Bashkirian megazone – a major tectonic zone of the Southern Urals. More than 70 intrusions in different parts of the Bashkirian megazone (in the northern, central and southern part of the structure) were sampled. The studied intrusions have Riphean age, however, like a significant part of the rocks of the Southern Urals, these intrusive bodies were remagnetized during the Late Paleozoic collision within the Urals fold belt. This article will discuss the secondary Late Paleozoic component of natural remanence magnetization. According to the paleomagnetic data obtained, the secondary Late Paleozoic component in most of the Bashkirian megazone is post-fold, i.e. formed after the completion of the main phase of fold deformations in the Southern Urals. A comparison of paleomagnetic directions obtained from intrusions in different parts of the Bashkirian megazone showed that there did not significant movements of individual parts of the Bashkirian megazone relative to each other after the formation of the Late Paleozoic component. The Late Paleozoic remanence component yielded a paleomagnetic pole of Plong = 171.6°, Plat = 39.9°, α95 = 5.9°, N = 6 from 6 areas (38 sites) in the Bashkirian megazone. The obtained pole is statistically indistinguishable from the mean of 15 poles for Stable Europe with ages of 280–301 million years. Thus, the secondary Late Paleozoic component in the Bashkirian megazone formed approximately 280–301 million years ago, after which the Bashkirian megazone did not experience any relative motions with respect to the East European craton.

Vertical and radial distribution of atomic carbon in HD 163296

Context. In protoplanetary disks, atomic carbon is expected to originate from the photo dissociation region at the disk surface where CO is dissociated by ultraviolet (UV) photons coming from the stellar, or external interstellar, radiation field. Even though atomic carbon has been detected in several protoplanetary disks, there is a lack of spatially resolved observations of it. Aims. For the HD 163296 protoplanetary disk, we aim to obtain both the radial and vertical structure of [CI] = 3P1 − 3P0 line emission and perform the first direct comparison of this tracer with the optically thick line emission 12CO J = 2 − 1. Methods. We used archival ALMA data for [CI] = 3P1 − 3P0 and previously published12 CO J = 2 − 1 data in HD 163296. Through the disksurf software, we extracted the vertical structure; meanwhile, we obtained the radial profiles directly from imaging. Brand new DALI modeling was employed to perform a direct comparison with the data. Results. We find that these tracers are colocated radially but not vertically, where the 12CO J = 2 − 1 emission is, on average, located at higher altitudes, as is also the case for other tracers in the same disk. Conclusions. Due to this difference in the vertical height of the emission, the optically thick 12CO J = 2 − 1 emission line appears to trace the highest altitudes, despite the expected formation mechanism of [CI] in the disk. The latter phenomena may be due to efficient mixing of the upper layers of the disk, or UV photons penetrating deeper than we expected.

Effect of multiple sclerosis and aging on prospective memory using the ecological test of prospective memory.

Prospective memory (PM) is the ability to remember to produce an action at a specific moment in the future signaled by the occurrence of a specific event (event-based [EB] condition), a time or a time interval (time-based [TB] condition). Detection of the appropriate moment corresponds to the prospective component, while production of the appropriate action corresponds to the retrospective component. Although PM difficulties have been reported in healthy aging and in association with multiple sclerosis (MS), PM has not been examined in older persons with MS (PwMS). The main objective of this study was to investigate whether the decline in PM performance with advancing age is influenced by the presence of MS. This study also aimed to clarify the type of PM impairment (prospective vs. retrospective component in TB and EB conditions) in MS as a function of age. A total of 80 participants were recruited and separated into four groups: older PwMS (n = 20), younger PwMS (n = 20), older controls (n = 20), and younger controls (n = 20). PM and its components were measured using the Test Ecologique de Mémoire Prospective (TEMP), an experimental ecological tool using naturalistic stimuli developed by our laboratory that has been validated in previous studies. On the TEMP total score, a two-way analysis of covariance showed a main effect of age, a main effect of the presence of MS, as well as a significant Age × Disease interaction. Direct comparison between EB and TB conditions revealed that for the prospective component, only older PwMS had more difficulty in the TB than in the EB condition, whereas the retrospective component score was significantly lower in the TB than in the EB condition in all groups except in younger controls. The TEMP revealed a marked impairment in PM in older PwMS compared to older controls and young PwMS. This impairment was particularly evident on the prospective component in the TB condition. Retrospective difficulties noted in the TB condition in all, but younger controls reflect the arbitrary nature of the cue-action link that is particularly sensitive to episodic memory difficulties often observed in aging and MS. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Enhancing machining efficiency of Ti-6Al-4V through multi-axial ultrasonic vibration-assisted machining and hybrid nanofluid minimum quantity lubrication

Ti-6Al-4V offers a balance of good strength with lightweight properties. Yet, Ti-6Al-4V poses machining challenges, including low thermal conductivity, chemical adhesion to cutting tools, and chip removal difficulties. To improve machining efficiency, Ultrasonic Vibration-Assisted Machining (UVAM) has emerged as a promising approach. UVAM has demonstrated reduced tool wear, cutting forces, and improved surface quality compared to Conventional Machining (CM). Additionally, Minimum Quantity Lubrication (MQL) methods offer sustainable coolant alternatives, with recent research focusing on Nanofluid-MQL (NMQL) and Hybrid Nanofluid-MQL (HNMQL) for enhanced performance. Although there exists a body of literature showcasing the promising effects of UVAM and MQL methods individually, comprehensive investigations into the synergistic effects of these methodologies remain limited. This study addresses these critical research gaps by conducting a systematic examination of combined application of multi-axial UVAM and HNMQL. Specifically, it delves into the comparison of different vibration directions within UVAM, evaluates the effectiveness of UVAM when combined with cutting fluids incorporating Al2O3 and CuO nanoparticles in NMQLs and HNMQLs, and contrasts these novel approaches with conventional machining methods. The study unfolds in three distinct stages. The first stage examines the ultrasonic cutting mechanism and its combined application with the MQL technique. In the second stage, the study investigates the physical properties of the cutting fluids, including contact angle and surface tension. The final stage encompasses slot milling operations, where an array of parameters such as cutting forces, surface roughness, surface topography, surface texture, and the occurrence of burr formations are rigorously analyzed. The results demonstrate that the combination of multi-axial UVAM with HNMQL yields substantial advantages over traditional machining methods. Notably, it leads to a remarkable reduction in cutting forces (up to 37.6 %) and surface roughness (up to 37.4 %). Additionally, this combination engenders the production of highly homogeneous and uniform surface textures, characterized by minimal surface defects and a significantly diminished occurrence of burr formations. These findings underscore the potential of multi-axial UVAM combined with HNMQL as a promising approach in enhancing the machining of Ti-6Al-4V, thus offering a pathway to enhance the efficiency and precision of aerospace component manufacturing processes.

705 Urgent or Emergent Endovascular Intervention for Neurological Deficits Post-carotid Endarterectomy: A Single-institutional Case Series and Systematic Review of the Literature

INTRODUCTION: Historically the management of acute neurological deficit following carotid endarterectomy (CEA) has been operative re-exploration; however, given the proliferation of endovascular techniques, and utilization of CT angiography, endovascular intervention is an alternative to redo-CEA. METHODS: All patients undergoing CEA in the Department of Neurosurgery at Rhode Island Hospital (Providence, RI) were reviewed. A systematic literature review was conducted in PubMed according to PRISMA guidelines to identify papers relevant to endovascular procedures addressing acute neurological deficits following CEA, which yielded 2499 unique articles. Review by 2 investigators revealed 12 relevant articles. RESULTS: Four patients from our institutional cohort met inclusion criteria. Among these, stenting was technically successful in 3 patients, 2 of which achieved near-full recovery. One patient underwent successful carotid stenting and ipsilateral M2 thrombectomy for tandem occlusion. Stent placement was unsuccessful in the remaining patient due to mechanical constriction. Articles obtained through the literature review revealed 57 further relevant cases. Of those with sufficiently complete data, 30/39 (76.9%) were male with an age range of 43 - 78 years old. Twenty-eight of 32 (87.5%) patients underwent CEA for symptomatic carotid stenosis. Post-CEA angiographic evaluation was most commonly conducted for routine completion imaging (21/57, 36.8%), non-specific stroke symptoms (15/57, 26.3%), and extremity weakness (7/57, 12.3%). Thrombotic stenosis (23/43, 53.4%) and arterial dissection (15/43, 34.9%) were the most common angiography findings. Two (3.5%) stent procedures were unsuccessful, and in the immediate postoperative period 8 patients (14.0%) had significant neurological deficits and only 3 deaths (5.3%) were reported. CONCLUSIONS: Endovascular intervention may be considered in situations where patients have neurological deficit after CEA. Direct comparison of outcomes in patients who have endovascular intervention vs. redo CEA may help identify the optimal management strategy.

A Perceptual Model-Based Approach to Plausible Authoring of Vibration for the Haptic Metaverse.

Haptic virtual reality is often misunderstood as being solely a physically identical copy of real environments. Thus, a perfect recording and reproduction of vibration that is indistinguishable in an A:B comparison is often the aim. However, in most virtual reality applications the real environment is not available for direct comparison. Instead, when judging the plausibility of a presented scene, the user compares the vibration to his expectations shaped by the audiovisual context. Therefore, it should be sufficient to find any vibration that the user expects to potentially occur in the given context. Such a vibration needs to elicit a perceptual profile with a minimal distance to an expected profile in the sensory tactile perceptual space. Building onto this formalization, this article demonstrates a novel generative model-based approach to authoring vibrations. First, users quantify expectations as tactile profiles consisting of ratings of six sensory tactile attributes without the presence of vibrations. Subsequently, the model predicts vibration parameters from such profiles. This ensures the fulfillment of user expectations and thus high plausibility. Furthermore, it eliminates the necessity of recordings, infeasible for scenes with no real counterpart and opens the door to crowdsourcing the authoring process with laypersons for the haptic metaverse.

Characterising the declarative-procedural transformation in instruction-based learning.

Many accounts of instruction-based learning assume that initial declarative representations are transformed into executable procedural ones, so as to enable instruction implementation. We tested the hypothesis that declarative-procedural transformation should be bound to a specific response modality and not transferable across different modalities. In Experiment 1, novel stimulus-response instructions had to be implemented either verbally or manually either once or three times. Modality-specific procedural encoding was probed via a subsequent implicit priming test. This involved the same stimuli but required a response that could be either compatible or incompatible with the originally instructed response using either the same or a different response modality. We found that procedural encoding was modality-specific as indicated by a stronger repetition-dependent increase of the compatibility effect when response modality was unchanged. Explicit test performance, serving as a marker of declarative encoding, was independent of modality transition and it was uncorrelated with implicit test performance. Unexpectedly, the implicit priming test also revealed a small yet significant transfer to the response modality that was previously not overtly implemented, likely reflecting covert response "simulation". To examine if covertly simulated responding occurs even when instruction implementation is omitted altogether, we conducted Experiment 2. Subjects merely viewed novel stimulus-response instructions prior to testing. Again, we found evidence for procedural encoding of the non-implemented instructions. Moreover, a direct comparison of both experiments revealed higher test scores (both implicit and explicit) for previously non-implemented instructions than for previously implemented instructions. This calls for theoretical reconciliation with diverging previous study results.

Comapping Cellular Content and Extracellular Matrix with Hemodynamics in Intact Arterial Tissues Using Scanning Immunofluorescent Multiphoton Microscopy.

Deviation of blood flow from an optimal range is known to be associated with the initiation and progression of vascular pathologies. Important open questions remain about how the abnormal flow drives specific wall changes in pathologies such as cerebral aneurysms where the flow is highly heterogeneous and complex. This knowledge gap precludes the clinical use of readily available flow data to predict outcomes and improve treatment of these diseases. As both flow and the pathological wall changes are spatially heterogeneous, a crucial requirement for progress in this area is a methodology for acquiring and comapping local vascular wall biology data with local hemodynamic data. Here, we developed an imaging pipeline to address this pressing need. A protocol that employs scanning multiphoton microscopy was developed to obtain three-dimensional (3D) datasets for smooth muscle actin, collagen, and elastin in intact vascular specimens. A cluster analysis was introduced to objectively categorize the smooth muscle cells (SMC) across the vascular specimen based on SMC actin density. Finally, direct quantitative comparison of local flow and wall biology in 3D intact specimens was achieved by comapping both heterogeneous SMC data and wall thickness to patient-specific hemodynamic results.

Quadrat soil pollen signal reflects plant important values in forests and shrublands from subtropical China.

Pollen analysis, a crucial tool in botany and ecology for examining historical biotic dynamics, has elicited debate owing to its complex link with vegetation. The challenge lies in discerning the ecological significance of pollen data. In this study, we conducted detailed quadrat surveys on Jinhua Mountain, subtropical China, analyzing topsoil pollen to determine whether pollen signals accurately reflect key ecological components in the forests and shrublands. We performed direct comparisons between pollen and plant compositions and calculated pollen percentages and plant Important Values (IVs) for each quadrat. The results indicate greater homogeneity in pollen composition across the study area compared to plant composition, particularly in the high percentage of Pinus pollen. However, distinct plant communities exhibited significantly different pollen compositions, as evidenced by the multi-response permutation test. This divergence aligns with variations in the dominant plant species across different communities. There were significant correlations between pollen percentages and plant IVs, with correlation coefficients of 0.55 (p < 0.001) at the quadrat level and 0.78 (p < 0.001) at the taxon level. These results support the utility of pollen analysis for representing ecologically significant values in subtropical Chinese forests and shrublands. Such correlations might also be extrapolated to pollen-based paleoecological studies.

Assessment of optimal combinations of therapeutic probiotics for depression, anxiety, and stress.

Accumulating data show that probiotics may be beneficial for reducing depressive, anxiety, and stress symptoms. However, the best combinations and species of probiotics have not been identified. The objective of our study was to assess the most effective combinations and components of different probiotics through network meta-analysis. A systematic search of four databases, PubMed, Web of Science, Cochrane, and Embase, was conducted from inception to 11 January 2024. The GRADE framework was used to assess the quality of evidence contributing to each network estimate. We deemed 45 trials eligible, these included 4053 participants and 10 types of interventions. The quality of evidence was rated as high or moderate. The NMA revealed that Bifidobacterium exhibited a greater probability of being the optimal probiotic species for improving anxiety symptoms (SMD = -0.80; 95% CI -1.49 to -0.11), followed by Lactobacillus (SMD = -0.49; 95% CI -0.85 to -0.12). In addition, for multiple strains, compared with the other interventions, Lactobacillus + Bifidobacterium (SMD = -0.41; 95% CI -0.73 to -0.10) had a positive effect on depression. The NMA revealed that Lactobacillus and Bifidobacterium had prominent efficacy in the treatment of individuals with anxiety, depression, and combination of Lactobacillus + Bifidobacterium had a similar effect. With few direct comparisons available between probiotic species, this NMA may be instrumental in shaping the guidelines for probiotic treatment of psychological disorders.

Heatwaves are detrimental to fertility in the viviparous tsetse fly.

Heatwaves are increasing in frequency and intensity due to climate change, pushing animals beyond physiological limits. While most studies focus on survival limits, sublethal effects on fertility tend to occur below lethal thresholds, and consequently can be as important for population viability. Typically, male fertility is more heat-sensitive than female fertility, yet direct comparisons are limited. Here, we measured the effect of experimental heatwaves on tsetse flies, Glossina pallidipes, disease vectors and unusual live-bearing insects of sub-Saharan Africa. We exposed males or females to a 3-day heatwave peaking at 36, 38 or 40°C for 2 h, and a 25°C control, monitoring mortality and reproduction over six weeks. For a heatwave peaking at 40°C, mortality was 100%, while a 38°C peak resulted in only 8% acute mortality. Females exposed to the 38°C heatwave experienced a one-week delay in producing offspring, whereas no such delay occurred in males. Over six weeks, heatwaves resulted in equivalent fertility loss in both sexes. Combined with mortality, this lead to a 10% population decline over six weeks compared to the control. Furthermore, parental heatwave exposure gave rise to a female-biased offspring sex ratio. Ultimately, thermal limits of both survival and fertility should be considered when assessing climate change vulnerability.

Dissociable neural correlates of trait and ability emotional intelligence: a resting-state fMRI study.

Emotional intelligence (EI) is one's ability to monitor one's own and other's emotions and the use of emotional information to enhance thought and action. Previous behavioral studies have shown that EI is separable into trait EI and ability EI, which are known to have distinct characteristics at the behavioral level. A relevant and unanswered question is whether both forms of EI have a dissociable neural basis. Previous studies have individually explored the neural underpinnings of trait EI and ability EI, but there has been no direct comparison of the neural mechanisms underlying these two types of emotional intelligence. The present study addresses this question by using resting-state fMRI to examine the correlational pattern between the regional amplitude of low-frequency fluctuations (ALFF) of the brain and individuals' trait EI and ability EI scores. We found that trait EI scores were positively correlated with the ALFF in the bilateral superior temporal gyrus, and negatively correlated with the ALFF in the ventral medial prefrontal cortex. In contrast, ability EI scores were positively correlated with the ALFF in the insula. Taken together, these results provide preliminary evidence of dissociable neural substrates between trait EI and ability EI.

Situating the phosphonated calixarene-cytochrome C association by molecular dynamics simulations.

Protein-calixarenes binding plays an increasingly central role in many applications, spanning from molecular recognition to drug delivery strategies and protein inhibition. These ligands obey a specific bio-supramolecular chemistry, which can be revealed by computational approaches, such as molecular dynamics simulations. In this paper, we rely on all-atom, explicit-solvent molecular dynamics simulations to capture the electrostatically driven association of a phosphonated calix-[4]-arene with cytochome-C, which critically relies on surface-exposed paired lysines. Beyond two binding sites identified in direct agreement with the x-ray structure, the association has a larger structural impact on the protein dynamics. Then, our simulations allow a direct comparison to analogous calixarenes, namely, sulfonato, similarly reported as "molecular glue." Our work can contribute to a robust in silico predictive tool to assess binding sites for any given protein of interest for crystallization, with the specificity of a macromolecular cage whose endo/exo orientation plays a role in the binding.