DMSO) And N,N-dimethylformamide Research Articles

Photoluminescent supramolecular gels derived from phenylenediamine hydrochlorides.

Supramolecular gels are promising as chemosensors, drug delivery systems and oil gelators. The present paper deals with photoluminescent supramolecular gels derived from phenylenediamine hydrochlorides. N-(3,5-Diaminobenzoyl)-L-alanine dodecyl ester dihydrochlorides (1L) underwent gelation in tetrahydrofuran (THF) and CHCl3, but not in C1-C4 alcohols, dimethyl sulfoxide (DMSO) and N,N-dimethylformamide (DMF). Compound 1L emitted blue fluorescence in the sol state and green fluorescence in the gel state. A THF solution of 1L exhibited absorption and emission maxima at wavelengths 94-104 nm and 92-110 nm longer than those in other solvents, such as methanol and ethanol, that cause no gelation of 1L. Particles with hydrodynamic diameters around 13 nm were detected in a THF solution (c = 1.0 mM) of 1L. The gelation of 1L in THF and CHCl3, and the lack of gelation in MeOH were supported by molecular dynamics simulations and dynamic light scattering measurements. N-(3,5-Diaminobenzoyl)-L-alanine dodecyl ester (1L'), an HCl-free analogous compound of 1L, underwent no gelation in THF and CHCl3, indicating the necessity of the ammonium salt structure for gelation. The UV-vis absorption and photoluminescence spectroscopic peaks of 1L red-shifted upon aggregation, which was supported by TD-DFT calculations of monomeric and dimeric models of 1L.

Synthesis of ursodeoxycholic acid by electrochemical stereoselective reduction of 7-ketolithocholic acid in aprotic solvents

A novel method of producing ursodeoxycholic acid was developed through electrochemical stereoselective reduction of 7-ketolithocholic acid (7K-LCA) in a undivided electrolytic cell and aprotic solvents as electrolyte. Five aprotic solvents were investigated as electrolytes, the simple structure of dimethyl sulfoxide (DMSO) and N,N-dimethylformamide (DMF) were easily attacked by chloride ions and undergo nucleophilic reactions, resulting in no target reactions. The structure of hexamethylphosphoric triamide (HMPA) and 1,3-methyl-3,4,5,6-tetrahydro-2 (1H) -pyrimidinone (DMPU) is relatively complex, but chloride ions can still attack them, and it was easier for 7K-LCA to directly undergo a reduction reaction under the action of electric current, because of the small steric hindrance of chenodeoxycholic acid (CDCA), 7K-LCA was stereoselectively reduced to CDCA. Due to the stable structure of the five-membered imidazole ring of 1,3-dimethyl-2-imidazolidinone (DMI), 7K-LCA undergoes two nucleophilic and a "Walden inversion", thereby stereoselective reduction of 7K-LCA to UDCA. In DMI, the highest conversion rate of 7K-LCA was 58.3%, the yield of UDCA was 34.9%, ee value was 100%. Linear sweep voltammetry was used to explore the electrochemical behavior of the reaction, and the electrolysis results were consistent with the linear sweep voltammetry. The product was characterized by using IR, 1H NMR and 13C NMR, it confirm the product was UDCA. The method developed in this paper provides a relatively environmentally friendly and low-consumption method for large-scale production of ursodeoxycholic acid, and provides a valuable reference for the asymmetric electrochemical reduction of ketone groups.

Mixed solvent atmosphere induces the surface termination state transition of perovskite to achieve matched energy level alignment

The optimal alignment of semiconductor's electronic energy level with respect to hole-transporting materials (HTMs and ETMs) determines the photovoltaic conversion efficiency of perovskite solar cells (PSCs). The energy level of perovskite can be greatly affected by the crystal surface termination state formed in the perovskite polycrystalline film preparation process. Perovskite featured with Pb-X termination always bears deep energy level which cannot match well HTM. Herein, to regulate the surface termination state of the perovskite crystals, a controlled solvent atmosphere dimethyl sulfoxide (DMSO) and N,N-dimethylformamide (DMF) was employed to induce the regrowth of perovskite crystals. Results prove that the mixed solvent of DMSO and DMF can induce perovskite crystals from Pb-X termination to A-X termination. Density functional theory (DFT) calculations show that the terminated conversion moves the valence and conduction band edge (VBE and CBE) of perovskite crystal to a shallower energy level, which does great favor to match the energy level of HTM, and then contributes to extracting charges. In addition, the defect density of the optimized perovskite polycrystalline film decreased from 1.258 × 1016 to 1.022 × 1016 cm -3, and the depletion width of PSCs increased from 48.9 to 56.1 nm. Profiting from the effective charge extraction and reduced non-radiative recombination, the open circuit voltage of the PSC increased from 0.99 to 1.09 V, and the conversion efficiency boosted from 17.8% to 20.3%..

Electronic Structure of Ytterbium(III) Solvates-a Combined Spectroscopic and Theoretical Study.

The wide range of optical and magnetic properties of lanthanide(III) ions is associated with their intricate electronic structures which, in contrast to lighter elements, is characterized by strong relativistic effects and spin-orbit coupling. Nevertheless, computational methods are now capable of describing the ladder of electronic energy levels of the simpler trivalent lanthanide ions, as well as the lowest energy term of most of the series. The electronic energy levels result from electron configurations that are first split by spin-orbit coupling into groups of energy levels denoted by the corresponding Russell-Saunders terms. Each of these groups are then split by the ligand field into the actual electronic energy levels known as microstates or sometimes mJ levels. The ligand-field splitting directly informs on the coordination geometry and is a valuable tool for determining the structure and thus correlating the structure and properties of metal complexes in solution. The issue with lanthanide complexes is that the determination of complex structures from ligand-field splitting remains a very challenging task. In this paper, the optical spectra-absorption, luminescence excitation, and luminescence emission-of ytterbium(III) solvates were recorded in water, methanol, dimethyl sulfoxide (DMSO), and N,N-dimethylformamide (DMF). The electronic energy levels, that is, the microstates, were resolved experimentally. Subsequently, density functional theory calculations were used to model the structures of the solvates, and ab initio relativistic complete active space self-consistent field calculations (CASSCF) were employed to obtain the microstates of the possible structures of each solvate. By comparing the experimental and theoretical data, it was possible to determine both the coordination number and solution structure of each solvate. In water, methanol, and N,N-dimethylformamide, the solvates were found to be eight-coordinated and have a square antiprismatic coordination geometry. In DMSO, the speciation was found to be more complicated. The robust methodology developed for comparing experimental spectra and computational results allows the solution structures of homoleptic lanthanide complexes to be determined.

Ultrafast Photochemistry of the [Cr(NCS)6]3- Complex in Dimethyl Sulfoxide and Dimethylformamide upon Excitation into Ligand-Field Electronic State.

The ultrafast photochemistry of the [Cr(NCS)6]3- complex upon excitation to the 4T2 ligand-field (LF) state was studied in dimethyl sulfoxide (DMSO) and N,N-dimethylformamide (DMF) in a wide temporal range (100 fs to 9 ms) by a combination of femtosecond and nanosecond transient absorption spectroscopy techniques and supported by quantum-chemical DFT/TD-DFT calculations. The initially excited 4T2 state undergoes intersystem crossing to the vibrationally hot 2E state with time constants of 1.1 ± 0.2 and 1.8 ± 0.1 ps in DMSO and DMF, respectively. Vibrational relaxation occurs in the same time scale and takes 1-5 ps. A major part of the [Cr(NCS)6]3- complex in the 2E state undergoes intersystem crossing to the ground state with time constants of 65 ± 5 and 85 ± 5 ns in DMSO and DMF, respectively. A minor part of electronically excited [Cr(NCS)6]3- undergoes irreversible photochemical decomposition. In DMSO, the photolysis of the [Cr(NCS)6]3- complex results in single or double isothiocyanate ion release followed by the coordination of the solvent molecules with a time constant of 1 ± 0.2 ms.

Headspace GC/MS Analysis of Residual Solvents in Dietary Supplements, Cosmetics, and Household Products Using Ethyl Lactate as a Dissolution Medium.

The static headspace technique is one of the most popular techniques for residual solvent analysis and dimethyl sulfoxide (DMSO) and N,N-dimethylformamide (DMF) are widely use as the dissolution media. This study aims to establish ethyl lactate (EL), a solvent with low toxicity and less environmental impact, as an alternative dissolution medium to DMSO and DMF for the static headspace analysis of toxic residual solvents in food, cosmetics, and similar complex organic matrices. Samples (a sample of dietary supplement and two samples each of cosmetics and household products) spiked with benzene, carbon tetrachloride, 1,2-dichloroethane, 1,1-dichloroethene, and 1,1,1-trichloroethane were dissolved in EL, DMSO, and DMF. Static headspace GC/MS and the standard addition method were used to detect and quantify the residual solvents. The dissolution and dispersion of these samples, especially the ones which were water-insoluble, were better than those in DMSO and DMF. The recoveries, except that of benzene in an aerosol spray, in EL ranged from 77 to 110%. The relative SDs in EL ranged from 2.5 to 11% and were better or equivalent to those in DMSO and DMF. EL was suitable as the dissolution medium for such samples, which may contain large amounts of organic solvents or various ingredients, in static headspace GC/MS analysis of residual solvents.

Maraviroc in aqueous co-solvent solutions of n-propanol, ethanol, dimethyl sulfoxide and N,N-dimethylformamide: Solubility determination, preferential solvation and solvent effect analysis

The liquid–solid equilibrium and solubility of maraviroc in co-solvent mixtures of n-propanol, ethanol, dimethyl sulfoxide (DMSO) and N,N-dimethylformamide (DMF) plus water was obtained via the saturation shake-flask technique between 278.15 K and 323.15 K under 101.2 kPa. For the four aqueous co-solvent mixtures investigated, the mole fraction solubility of maraviroc increased with the increase in the temperature and mass fraction of n-propanol, ethanol, DMSO and DMF. The maximum solubility values of maraviroc were observed in the neat co-solvents. The dependence of the maraviroc solubility on the solvent composition and temperature was mathematically correlated by means of the Jouyban-Acree model. The obtained values of relative average deviation (RAD) and root-mean-square deviation (RMSD) were no more than 4.16 × 10−2 and 49.13 × 10−6, respectively. KAT-LSER model was implemented to get quantitative information about solvent effect on the variation of solubility data. The variation in the maraviroc solubility was dependent upon the hydrogen-bond donation and cavity term in n-propanol + water and ethanol + water mixtures; and the cavity term was the dominant term in the (DMSO + water) and (DMF + water) mixtures. Quantitative study was made for the local mole fraction of ethanol (n-propanol, DMSO and DMF) and water around the maraviroc by the Inverse Kirkwood–Buff integrals method applied to the solubility data determined. Maraviroc was preferentially solvated by ethanol or n-propanol for the aqueous co-solvent mixtures of ethanol or n-propanol in intermediate and ethanol/n-propanol-rich compositions. It was conjecturable that maraviroc could act mainly as a Lewis acid in front to the ethanol or n-propanol molecules. However in the {n-propanol (1) + water (2)} mixture with compositions 0 < x1 < 0.20, ethanol (1) + water (2) mixture with compositions 0 < x1 < 0.25 and DMF/DMSO mixtures within entire compositions, maraviroc was preferentially solvated neither by co-solvent (1) nor by water.

Influence of temperature and solvents on the molecular interactions of Benzotriazole substituted 1,3,4-thiadiazole derivatives

Abstract Thermo-acoustical parameters of solutions of 2-(1H-benzo[d][1,2,3]triazol-1-yl)-1-(2-thioxo-5-(p-tolyl)-1,3,4-thiadiazol-3(2H)-yl)ethan-1-one, (SH10) and 2-(1H-benzo[d][1,2,3]triazol-1-yl)-1-(5-(4-methoxyphenyl)-2-thioxo-1,3,4-thiadiazol-3(2H)-yl)ethan-1-one, (SH11) in dimethyl sulfoxide (DMSO) and N,N-dimethylformamide (DMF) were evaluated. The density (ρ), viscosity (η) and ultrasonic sound velocity (U), various acoustical and thermodynamic parameters have been determined at three different temperatures viz. (298.15, 308.15 and 318.15 K) at atmospheric pressure. Furthermore, a comparison between experimental results for the pure solvents and solution of both the compound were studied to analyse how change in solvent and the structural modification affect the values of Gibbs energy of activation (ΔG*), enthalpy of activation (ΔH*) and entropy of activation (ΔS*).

Calculating the Gibbs Energies of Solvation of 2,2'-Dipyridyl in Nonaqueous Solvents

The Gibbs energies of solvation of 2,2'-dipyridyl (2,2'-Dipy) in methanol (MeOH), acetonitrile (AN), dimethylsulfoxide (DMSO), and N,N-dimethylformamide (DMF) are calculated via quantum chemical modeling. Estimates are made for the contributions from universal and specific types of interaction between the molecules of 2,2'-Dipy and the solvent to the change in the Gibbs energies of solvation of the amine when MeOH is replaced with AN, DMSO, and DMF.

Experimental solubility evaluation and thermodynamic analysis of quinocetone in aqueous co-solvent solutions of ethanol, isopropanol, dimethyl sulfoxide and N,N-dimethylformamide

Experimental measurement of drug quinocetone solubility in water-co-solvent mixtures of ethanol, isopropanol, dimethyl sulfoxide (DMSO) and N,N-dimethylformamide (DMF) were determined by the static equilibrium method at temperature range of (283.15–328.15) K under ambient condition (101.2 kPa). The solid phase equilibrated with liquor was examined by X-ray power diffraction, resulting in no polymorphic transformation, solvate formation or crystal transition compared to the raw material. Quantitative knowledge about the solvent effect on the solubility was obtained with the help of linear solvation energy relationships in the terms of dipolarity-polarizability, hydrogen-bond donor and acceptor ability, and cavity term of mixtures. The preferential solvation was investigated from their thermodynamic solution properties by means of the inverse Kirkwood-Buff integrals. The preferential solvation parameters (δx1,3) for ethanol, isopropanol, DMSO or DMF were negative in the four co-solvent mixtures with water-rich compositions, which indicated that quinocetone was preferentially solvated by water. Temperature has a little effect on the preferential solvation magnitudes for the ethanol and isopropanol mixtures. The higher solvation by water could be explained in terms of the higher acidic behavior of the solvents interacting with the Lewis basic groups of the quinocetone. In addition, thermodynamic co-solvency models including the Jouyban-Acree model, van’t Hoff-Jouyban-Acree model and Modified Apelblat-Jouyban-Acree model were employed to describe the solubility of this drug obtaining average relative deviations lower than 2.14% and root-mean-square deviations lower than 1.75 × 10−4 for correlative studies. The standard dissolution enthalpies of quinocetone in the solvent mixtures were positive, demonstrating that the dissolution process of quinocetone was endothermic.

Reduced-Dimensional α-CsPbX3 Perovskites for Efficient and Stable Photovoltaics

Summary Inorganic CsPbX3 perovskites have gained great attention owing to their excellent thermal stability and carrier transport properties. However, the power conversion efficiency (PCE) of solution-processed CsPbX3 perovskite solar cells is still far inferior to that of their hybrid analogues. Insufficient film thickness and undesirable phase transition are the two major obstacles limiting their device performance. Here, we show that by adopting a new precursor pair, cesium acetate (CsAc) and hydrogen lead trihalide (HPbX3), we were able to overcome the notorious solubility limitation for Cs precursors to fabricate high-quality CsPbX3 perovskite films with large film thickness (∼500 nm). We further introduced a judicious amount of phenylethylammonium iodide (PEAI) into the system to induce reduced-dimensional perovskite formation. Unprecedentedly, the resulting quasi-2D perovskites significantly suppressed undesirable phase transition and thus reduced the film's trap density. Following this approach, we reported a state-of-the-art PCE to date, 12.4%, for reduced-dimensional α-CsPbI3 perovskite photovoltaics with greatly improved performance longevity.

Synthesis of Novel Hyperbranched Polybenzo-Bisthiazole Amide with Donor⁻Acceptor (D-A) Architecture, High Fluorescent Quantum Yield and Large Stokes Shift.

Two novel highly fluorescent hyperbranched polybenzobisthiazole amides with a donor–acceptor architecture and large Stokes shift were rationally designed and synthesized. The chemical structures of the prepared hyperbranched polymers were characterized using Fourier Transform Infrared Spectroscopy (FTIR) analysis, Hydrogen Nuclear Magnetic Resonance (1H-NMR) analysis, and Gel Permeation Chromatography (GPC) analysis. These two polymers were soluble in dimethyl sulfoxide (DMSO) and N,N-dimethylformamide (DMF), and their DMSO and DMF solutions emitted strong green light (517–537 nm) with high quantum yields (QYs) and large Stokes shifts. Their relative fluorescence QYs in the DMSO solution were calculated as 77.75% and 81.14% with the Stokes shifts of 137 nm (0.86 eV) and 149 nm (0.92 eV) for HP–COOH and HP–NH2, respectively, using quinine sulfate as the standard. In the DMF solution, the QYs of HP–COOH and HP–NH2 were calculated as 104.65% and 118.72%, with the Stokes shifts of 128 nm (0.79 eV) and 147 nm (0.87 eV), respectively. Their films mainly emitted strong blue light with the maximum emission wavelengths of 436 nm and 480 nm for HP–COOH and HP–NH2, respectively. The Stokes shifts for HP–COOH and HP–NH2 films were 131 nm (0.42 eV) and 179 nm (0.86 eV), respectively. They are promising candidates for luminescent solar concentrators and blue light emitting materials.

Effect of task specific thiocyanate based ionic liquids on relative volatility of cyclohexane and benzene azeotropic mixture

The relative volatilities of cyclohexane (Cy) to benzene (Bz) in the presence of eight task-specific imidazolium thiocyanate ionic liquids (ILs) were measured using headspace gas chromatography. The ILs contain nitrile, ally, benzyl and hydroxyl functional group in their imidazolium cations and thiocyanate as anion. The effects of incorporation of nitrile, allyl, benzyl and hydroxyl functional groups in imidazolium alkyl chain on the relative volatility of Cy to Bz were investigated using experiment and quantum calculations. COSMO-RS model was used to study the polarity (charge distribution) of the ILs and the solutes. Density functional theory (DFT) was employed to investigate the cation-anion interaction energies and IL-Bz/Cy binding energies. The structural variations of the imidazolium cation influence the performance of the ILs. Moreover, the performances of the ILs were compared with two typical conventional entrainers, dimethyl sulfoxide (DMSO) and N,N-dimethylformamide (DMF). Except two hydroxyl containing ILs, the remaining six ILs show higher Cy to Bz relative volatility values compared to the bench marked conventional solvents.

Enhanced thermoelectric performance of PEDOT:PSS films by solvent thermal treatment

Flexible free-standing PEDOT:PSS films were thermally treated by various of high polar organic solvents such as N-methyl-2-pyrrolidone (NMP), ethylene glycol (EG), dimethyl sulfoxide (DMSO) and N,N-dimethylformamide (DMF), and a comparative thermoelectric (TE) study was conducted in the present work. Due to the synergistic effect of high polar solvent and thermal treatment, the maximum electrical conductivity of PEDOT:PSS films was up to 520 S cm−1 by EG post-treatment at its boiling point (197 °C), resulting in a power factor of 14.9 μW m−1 K−2, which was four orders of magnitude higher than pure PEDOT:PSS film (~0.005 μW m−1 K−2). The improvement of TE performance is primarily caused by the increased electrical conductivity and the steady Seebeck coefficient. As observed from atomic force microscope (AFM) and X-ray photoelectron spectroscopy (XPS) characterization, the enhancement of electrical conductivity is attributed to the removal of excess insulating PSS from the PEDOT:PSS film surface and the separation of the rest PSS chains in the polymer matrix from the PEDOT phase.

Thermochemical Properties of Dissolution of Nitroguanidine in Dimethyl Sulfoxide and N,N-Dimethylformamide

Abatract. The enthalpies of dissolution for nitroguanidine (NQ) in dimethyl sulfoxide (DMSO) andN,N-dimethylformamide (DMF) were measured using a RD496-2000 Calvet microcalorimeter at 298.15 K. Empirical formula for the calculation of the enthalpies of dissolution (ΔdissH) was obtained from the experimental data of the dissolution processes of NQ in DMSO and DMF. The corresponding kinetic equations describing the dissolution processes were dα/dt=10-1.49(1-α)0.94for the dissolution of NQ in DMSO and dα/dt=10-1.59(1-α)0.90for the dissolution of NQ in DMF.

A facile and highly efficient strategy for esterification of poly(meth)acrylic acid with halogenated compounds at room temperature promoted by 1,1,3,3-tetramethylguanidine

Esterifications of poly(methacrylic acid) (PMAA) and poly(acrylic acid) (PAA) have been investigated with a wide variety of halogenated compounds such as iodide, bromide, and chloride using 1,1,3,3-tetramethylguanidine as a promoter. The results demonstrate that the poly(meth)acrylates can be obtained with an excellent degree of esterification at room temperature. The influence of solvent, reaction conditions, and halogenated compounds on the esterification reaction was examined. It was found that polar solvents, such as dimethyl sulfoxide (DMSO) and N,N-dimethylformamide (DMF), are favorable for the esterification and high degree of esterification can be achieved in a short time. Moreover, the esterification reaction of PMAA has been successfully performed in an aqueous solution of DMSO, which indicates that the solvent does not necessarily have to be dried for this reaction. Primary and secondary halogenated compounds can successfully react with PMAA or PAA, while tertiary halogenated compounds fail to react. In addition, combining this esterification reaction with atom transfer radical polymerization (ATRP), macromonomers were conveniently prepared by the reaction of halogen-capped polymers with methacrylic acid under mild conditions.

Influence of acido ligands on the structure of copper dihalide solvates with dimethyl sulfoxide and N,N-dimethylformamide

Structures of copper dihalide solvates with dimethyl sulfoxide (DMSO) and N,N-dimethylformamide (DMF) were determined by XRD single crystal analysis. The existence of two DMSO solvates with CuBr2, but only one with CuCl2, was attributed to a lower Cu-Br bond strength in comparison with Cu-Cl, and, as a consequence, by its easier breaking to form a bond with a solvent molecule. Fundamentally different structures of CuX2·2DMF (X = Br, Cl) solvates are caused by different donor power of the acido ligands.

ChemInform Abstract: Synthesis, Characterization, and Solution Properties of New Heterocyclic Tellurium Compounds Based on 5,6-Dimethyl-1,3-dihydro-2-telluraindene.

The synthesis and characterization of a new range of heterocyclic tellurium compounds based on 5,6-dimethyl-1,3-dihydro-2-telluraindene are reported. Conductivity measurements of most compounds in dimethylsulfoxide (DMSO) and N,N-dimethylformamide (DMF) showed considerable ionic character in both solvents. 1H and 13C NMR studies indicated that the telluronium salts are stable to reductive elimination and no reaction between solute and solvent was observed. Benzyl and allyl telluronium salts are exceptional. Infrared and mass spectral data are reported and discussed.

Synthesis and characterization of dextrin-grafted polypropylene

We carried out the graft copolymerization of the water-soluble natural polymer dextrin onto preirradiated polypropylene (PP) in an aqueous medium using benzoyl peroxide (BPO) as the radical initiator. PP was irradiated by γ rays from a Co60 source at a constant dose rate of 3.40 kGy/h to introduce hydroperoxide linkages, which served as the sites for grafting. The graft copolymerization was studied as a function of different reaction parameters, and the maximum percentage grafting (Pg; 55%) of dextrin onto PP was obtained at optimum conditions of [BPO] = 5.165 × 10−2 mol/L, temperature = 60°C in 120 min with 15 mL of water. Different grafting parameters, such as the percentage apparent grafting, percentage grafting, and percentage true grafting have been evaluated. The graft copolymers were characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, and scanning electron microscopy. Swelling studies were carried out in pure, binary, ternary, and quaternary solvent systems composed of water, ethanol (EtOH), dimethyl sulfoxide (DMSO), and N,N-dimethylformamide (DMF) at different ratios. The maximum swelling percentage PP-g-dextrin (both composite and true graft) was observed in pure DMSO and DMF followed by EtOH and water. Water-retention studies of PP and PP-g-dextrin (both composite and true graft) were investigated at different time periods, temperatures, and pH values. The maximum percentage water retention of PP-g-dextrin (composite, 124%) was observed at 8 h and 50°C in a neutral medium (pH 7). © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011

A novel thermophilic lipase from Fervidobacterium nodosum Rt17-B1 representing a new subfamily of bacterial lipases

Abstract Thermophilic enzymes have significant potential for industry applications due to their high inherent stability and high reaction rates at high temperatures. In this study a gene coding for a putative lipase composed of 302 amino acids from an anaerobic thermophilic bacterium Fervidobacterium nodosum Rt17-B1 was cloned and characterized. Phylogenetic analysis suggests that this novel lipase represents a new subfamily of family I of bacterial lipases, annotated as family I.8. The recombinant protein can catalyze the hydrolysis of p-nitrophenyl esters and shows substrate preference for p-nitrophenyl caprate with a kcat/Km of 22,500 s−1 μM−1. Most importantly, it can hydrolyze triacylglycerols with long acyl chains. In the test conditions applied here it has a maximum activity at 70 °C and pH 9.0 and displays extreme thermal stability. Interestingly, it was not only stable, but was also activated by treatment with polar organic solvents including propanol, acetone, dimethyl sulfoxide (DMSO) and N,N-dimethylformamide (DMF). Structural modeling showed that it is composed of an α/β-hydrolase fold and a lid domain comprised of four α-helices. A canonical catalytic triad consisting of Ser119, Asp206 and His282 was verified by site-directed mutagenesis.