The Hierarchical Taxonomy of Psychopathology (HiTOP) is a recently proposed dimensional model of psychopathology that aims to provide a more comprehensive understanding of the organization of mental disorders. The Symptom Checklist-90-Revised (SCL-90-R) is a widely used self-report questionnaire that assesses nine broad dimensions of psychopathologies. The current study reexamined the optimum factor structure of the SCL-90-R (first aim), and its usefulness for the assessment of psychological dimensions from a HiTOP perspective (second aim). These were examined in a community sample of adolescents from Cyprus. A total of 839 adolescents (males = 352, females = 485; no response = 2) with ages ranging from 14 to 18 years [mean (SD) = 15.52 years (0.64 years)] completed the SCL-90-R and the Fünf-Faktoren-Fragebogen für Kinder (FFFK), a personality measure of the Five-Factor Model of personality. Relevant to the first aim, the findings showed the most support for an exploratory structural equal model, with the nine theorized SCL-90-R factors/dimensions. Relevant to the second aim, the SCL-90 dimensions of somatization, obsessive-compulsive, interpersonal sensitivity, depression, anxiety, hostility, and phobic anxiety were associated with the five factors in the FFFK as theoretically predicated by the HiTOP model. The SCL-90-R dimensions for paranoid ideation and psychoticism did not. The findings indicated reasonable support for the theorized nine-factor SCL-90 model; and the use of the SCL-90-R dimension scales of somatization, obsessive-compulsive, interpersonal sensitivity, depression, anxiety, hostility, and phobic anxiety for measuring the dimensions with similar names in the HiTOP model.