At present, the engineering designers generally design and analyze the precast structural models according to the equivalent cast-in-situ principle, and have a vague understanding of non-identical problems. However, these issues cannot be ignored, especially for high-intensity areas. This paper considers the differences of the hysteretic relationship between two typical precast joints and cast-in-situ (RC) joints, and researches the influence of these differences on the seismic response of frame structures. For the monolithic precast joint, the force mechanism was analyzed based on its assembly form, and the differences with the RC joint in the testing phenomena were explained accordingly. The dimensionless hysteresis models of two types of joints were proposed, and the rationality of the monolithic precast joint model was verified according to the existing experimental results. Different performances of joints were realized by assigning the constitutive models calculated from sectional reinforcement to the spring elements of analysis models. Considering two possible performance deficiencies of each type of precast joint separately, a total of seven structural analysis models were formed. Nonlinear static analysis and dynamic time-history analysis methods were adopted to reveal the differences between precast frames and the RC frame in terms of structural capacity curve, displacement response, ductility demands of components and structural residual deformation. The results showed that under strong seismic excitation, the response differences between precast frames and the RC frame were significant, so it is worthwhile to establish nonlinear models suitable for precast frames in seismic analysis. This study is valuable for understanding and distinguishing the nonlinear response of precast frames and traditional RC frames.