When dilute charged particles are confined in a bounded domain, boundary effects are crucial in the global dynamics. We construct a unique global-in-time solution to the Vlasov-Poisson-Boltzmann system in convex domains with the diffuse boundary condition. The construction is based on an $L^{2}$-$L^{\infty}$ framework with a novel \textit{nonlinear-normed energy estimate} of a distribution function in weighted $W^{1,p}$-spaces and a $C^{2,\delta}$-estimate of the self-consistent electric potential. Moreover we prove an exponential convergence of the distribution function toward the global Maxwellian.