Diketene Research Articles

Metal‐Free Assemblage of Four C−N and Two C−C Bonds via a Cascade Five Component Diastereoselective Synthesis of Pyrido[1,2‐a]Pyrimidines

AbstractAn efficient heteroannulation synthesis of N‐fused, pyrido[1,2‐a]pyrimidines was successfully achieved via a sequential, one‐pot five‐component reaction, involving primary amines, diketene (DK), differently substituted aromatic aldehydes, nitro ketene dithioacetal and propanediamine in ethanol at 70 °C. This new protocol constructs two rings through the formation of four C–N and two C–C bonds via a one pot sequential reaction involving ring‐opening/ Knoevenagel condensation, /nucleophilic substitution (SN)/ Michael addition followed by imine−enamine tautomerization and final N‐heterocyclization. The method is particularly attractive due to the advantages such as: atom economy, optimum convergence, commercially available or readily accessible starting materials, high bond‐forming efficiency, free metal‐catalyst and mild reaction conditions. The products were isolated by just decantation of the solvent and purification without using column chromatography method.

Diagnosis and treatment of acute diketene poisoning in children

2005年6月,我院儿科门诊收治23例二乙烯酮中毒患儿,现总结分析如下. 1 临床资料 1.1 一般资料 23例患儿中男12例,女11例,年龄最小8个月,最大14岁,平均年龄6.9岁,其中＜1岁3例,～3岁2例,～7岁9例,～14岁9例。

Analysis of 210 cases of ocular burn caused by diketene

目的 探讨双乙烯酮对眼部的损伤机制、表现、急救及预防措施.方法对双乙烯酮210例眼部损害进行回顾性分析.结果 402只眼均获治愈.并证实了现场结膜囊冲洗具有至关重要的作用,而维生素C、贝复舒、光安滴眼液则均可减轻组织反应,促进角膜上皮生长.结论及时有效的现场急救可明显减轻眼部原发性损害,而促进角膜上皮生长的滴眼液对眼部继发损害有确切的预防和治疗作用。

A Facile Synthesis of Novel 1,7‐Dihydropyrazolo[3,4‐b]pyridine‐4,6‐diones.

AbstractFor Abstract see ChemInform Abstract in Full Text.

Preparation and Structure of Di(2‐azulenyl)ketene Adducts. γ‐Lactone and β‐Lactam Derivatives.

AbstractFor Abstract see ChemInform Abstract in Full Text.

Preparation and Structure of Di(2-azulenyl)ketene Adducts. g-Lactone and b-Lactam Derivatives

Di(2-azulenyl)ketene (1) generated by thermal decomposition of diazodi(2-azulenyl)ethanone (2) via Wolff rearrangement of carbonyl carbene (8), and the reactive intermediate were confirmed by trapping reagents, such as azobenzene and cyclopentadienes. The reaction of 1 with tropone or imines afforded the corresponding γ -lactone (12) and β -lactams (15), respectively.

Synthesis of 2-quinolones from isatins and diketene

Synthesis of 2-quinolones from isatins and diketene

ChemInform Abstract: Acetoacetylation with Diketene (II) Catalyzed by 4‐Dimethylaminopyridine.

ChemInform Abstract: Acetoacetylation with Diketene (II) Catalyzed by 4‐Dimethylaminopyridine.

Why does a third of the world's diketene derivatives come from LONZA?

Why does a third of the world's diketene derivatives come from LONZA?

ChemInform Abstract: Cyclizations of Acetoacetates to α‐Acyltetronic Acids.

AbstractThe glycolates (I) react with diketene (II) to give the acetoacetates (III) which are cyclized in the presence of various additives to form α‐acetyltetronic acid (IV).

Acetoacetylation with Diketene Catalyzed by 4-Dimethylaminopyridine

Acetoacetylation with Diketene Catalyzed by 4-Dimethylaminopyridine

Rection of Isocynanic Acid and Isocynates with Diketene. Preparation of 2H-1,3-Oxazines, 4-Pyrones, and 2-Pyridones

Rection of Isocynanic Acid and Isocynates with Diketene. Preparation of 2H-1,3-Oxazines, 4-Pyrones, and 2-Pyridones

Two Unusual Trimers of Diketene

AbstractFormation of two unknown, tricyclic trimers of diketene, 3 and 4, was observed in diketene solutions containing (CH3)3SiCl/NaI or TsOH.

Synthesis of 2-quinolones from isatin and diketene

Synthesis of 2-quinolones from isatin and diketene

Studies on Ketene and Its Derivatives (CVIII). Photoreaction of Diketene with Uracil (Complement)

Studies on Ketene and Its Derivatives (CVIII). Photoreaction of Diketene with Uracil (Complement)

Studies on ketene and its derivatives. CVII. Photoreaction of diketene with 6-methyluracil.

Studies on ketene and its derivatives. CVII. Photoreaction of diketene with 6-methyluracil.

Studies on ketene and its derivatives. CV. Photoreaction of diketene with sec-alcohols.

Studies on ketene and its derivatives. CV. Photoreaction of diketene with sec-alcohols.

ケテンおよびその誘導体の研究(第104報)3-アミノクロトンアミド誘導体とジケテンとの反応

ケテンおよびその誘導体の研究(第104報)3-アミノクロトンアミド誘導体とジケテンとの反応

Studies on ketene and its derivatives. CVI. Photoreaction of diketene with N-phenylmaleimide and dimethyl-N-phenylmaleimide.

Studies on ketene and its derivatives. CVI. Photoreaction of diketene with N-phenylmaleimide and dimethyl-N-phenylmaleimide.

Addition of Alkanethiols to Diketene

Addition of Alkanethiols to Diketene