Abstract Background Digital technologies are increasingly indispensable in physicians’ clinical practice. Despite their advantages, they are also linked to information overload and constant availability, which might affect healthcare professionals’ quality of life. The study aims to investigate the utilisation of digital technologies among healthcare providers and to identify possible predictors of techno-stress associated with these technologies. Methods A cross-sectional study was conducted through an anonymous questionnaire distributed to Medical Doctors (MDs) via social media. The main outcomes were “Impact of digital technologies” and “E-mail overload” (EO), and “Whatsapp overload” (WO) as indicators of techno-stress. Univariable and multivariable regression models analyzed the association between the outcome variables and selected independent variables. Results Preliminary results were conducted on 246 MDs. Most respondents declared that using digital technologies positively impacted their relationship with patients and colleagues (67.1% and 56.7%, respectively). Multivariable linear regression analyses highlighted that variables associated with a higher or lower EO and/or WO were age (WO: adjusted coefficient (adjCoeff)=0.24, p = 0.004), being a specialist compared to a General Practitioner (GP) (EO: adjCoeff -8.42, p = 0.000; WO: adjCoeff=-5.2, p = 0.02), the number of patients visited each day (EO: adjCoef=16.10, p = 0.000; WO: adjCoeff=10.43, p = 0.001), working in a town with a larger population (EO: adjCoeff=-8.22, p = 0.001). Conclusions In agreement with the literature, GPs were the medical category most affected by techno-stress. Doctors with a higher volume of patients and who work in smaller towns have a higher likelihood of techno-stress. These findings underscore the necessity of interventions to address the issue, specifically through increased MD education and enhanced EU-wide regulations on digital technology use in healthcare. Key messages • Digital technologies positively impact physicians’ relationships with patients and colleagues, but also contribute to techno-stress, especially among General Practitioners and those with more patients. • Interventions like improved Medical Doctors’ education and stronger European regulations are needed to manage techno-stress and optimize the use of digital technologies in healthcare.