SummaryIn this paper, the massive multiple‐input multiple‐output fractional Fourier transform‐based orthogonal frequency division multiplexing (MIMO FrFT‐OFDM) system is investigated using the Long Range (LoRa) modulation technique. The conventional system relies on quadrature amplitude modulated (QAM) modulation technology; high‐power amplifiers are needed to transmit the QAM signal. The LoRa modulation technique produces long‐range and low power signals. The two‐wave with diffused power (TWDP) fading channel is used to examine the system's performance. The expression of the bit‐error rate (BER) of the proposed system is also represented in a unique closed form. The proposed system is applied to a state‐of‐the art hospital, one of the Internet of Things (IoT) applications. As the problem of heart stroke is common, it needs to be monitored every second. The electrocardiogram (ECG) data are used to evaluate how well the proposed system is working. Using the proposed model, the physicians get the patient's ECG data while moving in the hospital, getting it at a high data rate, at a low cost because of the extended battery life, a long range, and a low BER. The data considered are from the MIT‐BIH Arrhythmia Database. The result displays that the proposed model achieves a BER of at 10 dB of signal‐to‐noise ratio (SNR), and the conventional model achieves the same BER at 15 dB of SNR. The BER performance of the proposed system is improved by nearly 5 dB.