Diffuse Plasma Cell Infiltration Research Articles

Bone marrow fibrosis in newly diagnosed multiple myeloma and its correlation with clinicopathological factors

BackgroundBone marrow fibrosis (BMF) severely impacts both the quality of life and the efficacy of diagnostic procedures. However, the correlation between BMF and clinicopathological features, cytogenetic changes, and prognosis of newly diagnosed multiple myeloma (NDMM) remains unclear. This study determined the incidence, patient characteristics, and clinical outcomes of patients with NDMM with BMF.MethodsThe clinical data, histological features, and clinical outcomes of patients with NDMM were collected. Reticular fiber staining was performed on the enrolled cases, and the degree of reticular fiber overgrowth was graded. Patients with MF-2 and MF-3 were classified as the BMF+ group, and those with MF-0 and MF-1 were classified as the BMF- group, and BMF incidence was calculated. The differences in clinical data, histological features, and clinical outcomes between the BMF+ group and the BMF– group were compared.ResultsA consecutive series of 146 patients with NDMM were included. The incidence of MF-0, MF-1, MF-2, and MF-3 was 7.53% (11/146), 34.93% (51/146), 51.37% (75/146), and 6.16% (9/146), respectively. The incidence of BMF—MF-2 and MF-3—was 57.53% (84/146). A significant correlation was identified between the pattern of infiltration and BMF (P < 0.001). In the BMF- group, the distribution of cases with interstitial, nodular, and diffuse infiltration of plasma cells was 16 (25.8%), 21 (33.9%), and 25 (40.3%), respectively. Conversely, in the BMF+ group, these values for interstitial, nodular, and diffuse tumor cells were 9 (10.7%), 15 (17.9%), and 60 (71.4%). Furthermore, BMF was associated with a diffuse infiltration pattern. The overall survival (OS) of the BMF+ group (39.1 months; 95% confidence interval [CI]: 34.0–44.3) was lower than that of the BMF- group (45.4 months; 95% CI: 39.5–51.3), but there was no significant difference between the two groups (P = 0.221). Univariate and multivariate analyses showed that the BMF+ status was not associated with OS in patients with NDMM (P = 0.381 and P = 0.748, respectively).ConclusionsOur findings suggest that BMF is linked to a diffuse infiltration pattern, and its occurrence is not related to the prognosis of patients with NDMM, providing a basis for further exploring the BMF value in NDMM diagnosis and treatment.

Focal Plasmacytoid and Fibrotic Hepatic Lesion In An Autopsy Examination Of A Patient With Multiple Myeloma

Abstract Introduction/Objective Multiple Myeloma (MM) is a plasma cell neoplasm mainly affecting the bone marrow. Common sites of extramedullary dissemination are skin, liver, kidneys, and the central nervous system. Though diffuse plasma cell infiltration of the liver has been described in autopsy literature in about 50% of patients with multiple myeloma, it is usually not associated with focal infiltration. Rare cases of plasma cell infiltration leading to non-obstructive cholestasis and acute hepatic failure have been described. Methods/Case Report We hereby present a case of 54-year-old decedent male with past medical history of obesity, hypertension, and diabetes mellitus who presented to the emergency department with complains of productive cough, dyspnea, vomiting and back discomfort. Labs showed leukocytosis, thrombocytopenia and hypercalcemia. Additionally, there was an increase in lactate and serum monoclonal protein levels and derangements in renal and liver function tests. Skeletal bone survey showed a 1.4 cm well-circumscribed lucent lesion within the distal third of the left clavicle and in the calvarium which raised concern for multiple myeloma and tumor lysis syndrome. During the hospital course, the patient’s overall clinical condition declined rapidly, and he passed away on the third day of admission. During the autopsy examination, the patient’s bone marrow revealed diffuse infiltration of plasma cells confirming multiple myeloma. In addition, the histopathological examination of the liver revealed focal plasmacytoid fibrosis, moderate periportal inflammation with plasma cell infiltration and microsteatosis. Immunohistochemical stains with CD138, MUM-1, ISH kappa and lambda and trichrome highlighted the focal plasma cell infiltration and fibrosis in the liver, respectively. Results (if a Case Study enter NA) NA Conclusion Our case shows the importance of utilizing histopathological and immunohistochemical examination in confirming the diagnosis of multiple myeloma, specifically in the autopsy cases where there is no previous diagnosis of multiple myeloma. In addition, it highlights the awareness of rare focal plasmacytoid fibrosis and infiltration as an extramedullary presentation of multiple myeloma.

An Unusual Case of Multiple Myeloma Diagnosed due to Clinical Manifestations of Infiltration of the Disease into the Liver

: Clinical manifestations of infiltration of multiple myeloma into the liver are extremely rare. We present a case of a 73-year-old African-American female presenting with complaints of persistent nausea and vomiting. Initial laboratory findings included BUN of 23, creatinine 2.3, AST 73, ALT 59, alkaline phosphatase 335, total bilirubin 1.3 mg/dL, and direct bilirubin 0.7mg/dL. Serologic abnormalities persisted, prompting CT-guided biopsy of the liver. Pathology demonstrated diffuse plasma cell infiltration, and further work-up confirmed the diagnosis of multiple myeloma. Case Report: A 73-year-old female presented with complaints of nausea and vomiting of three weeks' duration, with associated intermittent diarrhea. Physical examination revealed a soft, nondistended abdomen, positive for periumbilical and epigastric tenderness with no guarding or rebound. Laboratory results were significant for a BUN of 23, creatinine 2.3, AST 73, ALT 59, alkaline phosphatase 335, total bilirubin 1.3 mg/dL, direct bilirubin 0.7mg/dL, and CA 19-9 of 352.7. Abdominal ultrasound, endoscopic ultrasound, and MRI of the abdomen with and without contrast was employed, but could not explain the persistent elevation in the patient's transaminases, alkaline phosphatase, and bilirubin. CT-guided biopsy of the liver was ordered. Findings of myelomatosis, an atypical plasmacytic infiltration of the liver, was described per the pathology. Serum and urine electrophoresis showed a lambda light chain predominance, with levels found to be 930 mg/dL and 1,960 mg/dL. Bone marrow aspiration confirmed a 17% marrow plasmacytosis, lambda restricted. The patient was diagnosed with multiple myeloma and started on treatment with bortezomib and dexamethasone. Discussion: Extraosseous involvement of multiple myeloma is a well-documented manifestation of the disease. Infiltration of the liver has been described in the literature, with Walz-Mattmüller, et al. reporting liver involvement in 32% of patients with multiple myeloma (1). Although liver infiltration and abnormalities in liver function tests are common, clinical manifestations of these irregularities are exceedingly rare (2). These instances exist in the literature as case reports, such as that described by Barth, et al., involving a patient presenting with acute cholestatic hepatitis diagnosed with multiple myeloma on biopsy of the liver (3). We report a similar case, in which a patient with complaints of nausea, vomiting, and obstructive cholestasis on serology was subsequently diagnosed with multiple myeloma. Although rare, manifestations of liver infiltration can occur, and physicians should remain vigilant in the work-up of cholestatic jaundice not explained by other pathology.

IgG4-related systemic diseases: a report of eight cases

To explore the clinical features of IgG4-related systemic diseases (IgG4-RSD) METHODS: A total of 8 inpatients with IgG4-RSD diagnosed at our hospital during August 2010 to December 2011 were recruited. We analyzed the clinical data, laboratory profiles, radiological and pathologic features and prognostic factors of these patients with IgG4-RSD. There were 5 males and 3 females with a mean onset age of 52.5 years. IgG4-related diseases were described in multiple organ systems: pancreas (n = 5), biliary tree (n = 3), kidneys (n = 6), lungs (n = 3), aorta and periaortic tissue, retroperitoneum(n = 5) and lymph nodes (n = 6). Hyperglobulinemia, elevated serum levels of IgG and IgG4, anemia(n = 6), renal dysfunctions (n = 5) and obstructive jaundice (n = 2) were common laboratory findings. Lymphoplasmacytic infiltration and fibrosis were common pathologic findings. A diffuse infiltration of plasma cells with over 30 IgG4-positive cells per high-power field provided compelling evidences of IgG4-related disease. Patients with IgG4-RSD responded well to glucocorticoids. With heterogeneous clinical characteristics, IgG4-RSD is found in various organ systems. The prominent histopathologic features of IgG4-RSD include a diffuse infiltration of plasma cells with over 30 IgG4-positive cells per high-power field. And the therapy of glucocorticoids is efficacious.

IgG4 expression in chronic sclerosing submaxillaritis

To analyze the clinicopathologic features of chronic sclerosing submaxillaritis (CSS). The clinical and pathological characteristics of 9 CSS were analyzed. In the 9 patients, there were 6 males and 3 females. The age of patients ranged from 51 - 77 years old. All of the tumors were located in the submandibular gland, presenting with painless and firm mass. Histologically, a well-defined mass lesion with extensive lymphocytes and plasma cells infiltration, preservation of lobular architecture, with acinar atrophy. The reactive hyperplasia of lymphoid follicles may be found in CSS. The phlebitis and obliterating phlebitis also formed. Immunohistochemistry showed evidence of diffuse infiltration of plasma cells. The mean number of IgG4-positive plasma cell per high-power field (HPF) was 186, mean value of the IgG4:IgG ratio was 0.71. Three of these 9 cases had manifestations of IgG4-associated systemic disease. CSS is considered as a part of IgG4-related sclerosing diseases, recognition of which is very essential for a successful treatment. When diagnosis is made, it is necessary to ascertain whether lesion occurs within salivary gland only or in combination with outside IgG4-related sclerosing disease. The establishment of follow-up is also necessary. Some patients show good response to steroid therapy.

Primary Pulmonary Plasmacytoma Presenting as Multiple Lung Nodules

Primary Pulmonary Plasmacytoma Presenting as Multiple Lung Nodules

A rare extramedullary involvement in myeloma: lung parenchyma and association with unfavorable chromosomal abnormalities.

Although pulmonary complications developing secondary to lung infections and involvement in ribs occur frequently in multiple myeloma (MM), involvement of the lung parenchyma is quite rare. In clinical studies, the involvement of lung parenchyma has been found to be associated with unfavorable prognosis. Here, a MM case in whom involvement of lung parenchyma was accompanied by unfavorable prognostic cytogenetic markers is presented. A 62-year-old male presented with complaint of cough, and heterogeneous hypodense mass was detected in thorax computerized tomography. The patient underwent bronchoscopic biopsy. Pathological examination revealed diffuse plasma cell infiltration staining with kappa immunohistochemically. In bone marrow biopsy, plasma cell infiltration was observed. In conventional cytogenetic examination, hypodiploidy was established. In cytogenetic examination carried out with fluorescence in situ hybridization, deletion (13q) was determined. In conclusion, in patients diagnosed with MM and presenting with pulmonary mass lesion, lung involvement associated with plasma cell infiltration should also be considered in the differential diagnosis. As overall survival is low in these cases, more aggressive treatment approaches such as high-dose treatment should be immediately considered.

Extramedullary plasmocytoma associated with a massive deposit of amyloid in the duodenum

We report a rare case of extramedullary plasmocytoma associated with a massive deposit of amyloid in the duodenum. A 72-year-old Japanese man was admitted to our hospital presenting with a 3-mo history of epigastric pain, vomiting and weight loss. On computed tomography (CT) a wall thickening of the fourth part of the duodenum was observed. Multiple biopsies obtained from the lesion showed infiltration of plasma cells and lymphocytes, but they were not conclusive. The patient underwent resection of the lesion and, on histopathological examination, the lesion consisted of a dense and diffuse infiltrate of plasma cells and a few admixed lymphocytes with reactive follicles extending to the muscular propria. An extensive deposition of amyloid was also observed. Immunohistochemical stains revealed that a few plasmacytoid cells showed lambda light chain staining, though most were kappa light chain positive. These cells also were positive for CD138 and CD56 but negative for CD20 and CD79. The findings were consistent with extramedullary plasmocytoma associated with a massive deposit of amyloid in duodenum. A subsequent workup for multiple myeloma was completely negative. The patient showed no signs of local recurrence or dissemination of the disease after 12 mo follow-up. Because of the association of plasmocytoma and amyloidosis, the patient must be followed up because of the possible systemic involvement of the neoplasm and amyloidosis in future.

Invasive inflammatory pseudotumor of uterine cervix: A case report

Background. Inflammatory pseudotumor (IPT) of the cervix uteri has been reported in only one patient. Here, we present a case of cervical IPT with bilateral parametrial involvement causing hydroureteronephrosis. Case. A 48-year-old, gravida 2, para 1, woman was referred for evaluation of lower abdominal pain and right-sided hydroureteronephrosis. On speculum and colposcopic examinations, the cervix appeared normal. Computed tomography scan revealed a 5 cm × 4 cm mass in the cervix invading both parametria. At laparotomy, the cervix was globally enlarged and both parametria were infiltrated by a tumor of rubbery consistency. After freeing both ureters, the cervix was removed with bilateral parametria and 2-cm vaginal cuff. Histologically, the tumor was characterized by proliferation of fibroblast-like spindle cells and diffuse infiltration of plasma cells and lymphocytes. Immunohistochemical staining showed that the lymphocytes were polyclonal. Immunostaining for smooth muscle actin was negative. The tumor was thus identified as inflammatory pseudotumor. Cervical stroma, bilateral parametria, and subepithelial tissues of the vagina were involved with tumor. However, invasion was not identified in the epithelia of the cervix and vagina or surgical margins of the resected specimen. Postoperative course was uneventful. There is no evidence of recurrent disease 8 months following surgery. Conclusion. The case we present is the second reported case of cervical IPT. It is unique in showing locally aggressive behavior. Surgical resection appears to be the treatment of choice for IPT.

An unusual presentation of helicobacter pylori infection: so-called “Russell body gastritis”

Helicobacter pylori (H. pylori) is a "slow" bacterial pathogen, which induces several gastroduodenal diseases. Varying degrees of inflammation can be present in the gastric mucosa of patients infected with H. pylori. The case presented here is a male patient suffering from dyspepsia and nausea. His upper gastrointestinal endoscopy revealed pan gastritis. Histological examination of multiple gastric biopsies taken from the body and antrum showed a rare morphological expression of H. pylori gastritis characterized by diffuse plasma cell infiltration with extensive Russell body formation. Diffuse infiltration of plasma cells with Russell bodies in gastric mucosa can cause difficulties in differentiation from neoplastic processes. However, immunohistochemically, the infiltrating cells in the gastric mucosa stained negatively with cytokeratins while they expressed both kappa and lambda light chains showing their polyclonal nature. The presence of diffuse plasma cells with Russell bodies in the gastric mucosa may represent a different presentation of H. pylori gastritis. There are only two case reports of similar presentation and both have been called "Russell body gastritis".

Organization of secondary lymphoid tissue and local IgE formation to Staphylococcus aureus enterotoxins in nasal polyp tissue

Bilateral nasal polyposis (NP) is characterized by high concentrations of IgE in NP tissue, which show no relation to the atopic status. We aimed to study the relationship between systemic and local IgE formation, nasal carriage of Staphylococcus aureus and nasal polyposis. In serum and nasal tissue homogenates from 24 NP patients and 12 controls, we determined concentrations of total IgE and IgE antibodies to inhalant allergens and S. aureus enterotoxins (SAEs; A,B,C,D,E,TSST) by ImmunoCAP. Tissue cryosections were stained for CD3, CD20, CD38, CD23, FcepsilonRI, IgE and SEA/SEB. We demonstrated a higher incidence of S. aureus colonization (17/24) and IgE antibodies to SAEs in NP tissue (12/24) compared with controls (3/12 and 0/12, respectively). Total IgE and IgE antibodies in serum and NP tissue were dissociated because of local polyclonal IgE formation in NP tissue. Staining of NP tissue revealed follicular structures characterized by B and T cells, and lymphoid accumulations with diffuse plasma cell infiltration. We demonstrated the organization of secondary lymphoid tissue in polyp tissue and a polyclonal hyper-immunoglobulinemia E associated with the presence of IgE antibodies to SAEs, colonization with S. aureus, and tissue eosinophilia in a relevant subgroup of polyp patients.

Leishmania major: The suitability of east african nonhuman primates as animal models for cutaneous leishmaniasis

The susceptibility of four species of East African nonhuman primates to experimental infection with Leishmania major was investigated. Four Syke's monkeys ( Cercopithecus mitis), two vervet monkeys ( Cercopithecus aethiops), two baboons ( Papio cynocephalus), and two brown bushbabies ( Galago garnettii) were each inoculated intradermally on the left eyelid, left ear, and nose with 0.1 ml of medium containing 1 × 10 7 promastigotes of a characterized L. major strain. All the nonhuman primates except the bushbabies developed erythema and conspicuous nodules on the eyelids and ears by 3 weeks PI. The nodules increased rapidly in size and ulceration was evident on the eyelids and ears by 49 days PI in the vervets, Syke's, and baboons. The aspirates were positive in culture or smears at 35, 49, 63, and 77 days PI. No parasites were observed in cultures or smears at 92, 105, 128, 147, and 161 days PI. The lesions in these animals began resolving by 84 days PI and were completely healed by 112 days PI. The exception was one baboon in which lesion healing did not start until around 147 days and was completely healed by 182 days PI. Cultures from the liver failed to demonstrate visceralization of the parasite in any of the animals throughout the 68 weeks of the experiment. Challenge with the same strain of L. major 6 months PI, corresponding to about 3 months after self cure, failed to produce infection in any of these experimental hosts. All the nonhuman primates except the bushbaby when challenged with the same strain of L. major at 12 months PI developed lesions and were positive for parasites at 14 and 28 days PI. Positive cultures were obtained from the eyelid and ear of one vervet up to 42 days PI. However, the lesion sizes in all these animals were smaller than in the initial infection and did not ulcerate. The nodules disappeared within 6 to 8 weeks as compared to 16 weeks in the initial infection. The histopathological appearance of the lesions varied from diffuse infiltration of plasma cells and lymphocytes which increased progressively to granulomata with epitheloid cells. This study shows that the vervets, Syke's, and the baboons are equally susceptible to L. major infection, while bushbabies are refractory. The vervets, Syke's, and baboons demonstrate a self-healing phenomenon within about 3 months which is comparable to that observed in humans infected with L. major. These three species of nonhuman primates are therefore considered as suitable models for drug or vaccine trials against human zoonotic cutaneous leishmaniasis.

Plasma cell infiltration of the small bowel: lack of evidence for a non-secretory form of alpha-heavy chain disease.

Eight patients with diffuse plasma cell infiltration of the small bowel who had the clinical features of immunoproliferative small intestinal disease (IPSID), but whose serum was negative for free alpha-heavy chains, were investigated for evidence of a non-secretory form of alpha-chain disease (alpha-CD). Molecular sieving and immunoblotting of serum, immunoperoxidase staining of biopsy specimens, and in vitro protein synthesis studies utilising an immunoprecipitation technique and polyacrylamide gel electrophoresis, failed to detect any new cases of alpha-CD. Four of the eight cases were found to have diffuse intestinal lymphoma. The remaining four patients, who were unsuccessfully investigated for evidence of a significant abnormality in cellular immunity, have not developed detectable alpha-CD protein or lymphoma over a mean of 143 months. Despite continuing exposure to possible environmental stimuli, it is concluded that not all cases of IPSID elaborate detectable alpha-CD protein or evolve to lymphoma.

A case of gastric plasmacytoma associated with Hashimoto's disease, primary biliary cirrhosis and Sjögren's syndrome

This 53 year-old female had been admitted to our hospital in 1975 with the complaints of general malaise, hoarseness and facial edema. She was diagnosed of Hashimoto's thyroidits, chronic active hepatitis and Sjogren's syndrome by biopsies of the thyroid glands, the liver and the salivary glands and was administered prednisolone, azathioprine and thyroid hormone.In 1981, she was admitted to our hospital for the second time with the complaint of left upper quadrant pain. The X-ray examination of the upper gastrointestinal tract and gastric endoscopy showed multiple ulcers with submucosal tumor at the gastric antrum. The biopsy specimen of the gastric mucosa suggested the diagnosis of malignant lymphoma of the stomach. However, subtotal gastrectomy was performed and surgical specimen demonstrated diffuse infiltration of plasma cells with pleomorphism. Immunohistochemical staining revealed in_??_ra cytoplasmic immunoglobulin, mainly IgM kappa and she was diagnosed of malignant extramedullary gastric plasmacytoma. Liver biopsy performed simultaneously showed characteristic changes of the primary biliary cirrhosis.We believe that this case is the first case of Sjogren's syndrome associated with extramedullary plasmacytoma of the stomach, Hashimoto's thyroiditis and the primary biliary cirrhosis.

Rectal mass caused by Treponema pallidum: Confirmation by immunofluorescent staining

A 37-yr-old homosexual man presented with mild anorectal symptoms, a diffuse maculopapular rash, constitutional symptoms, and a reactive serologic test for syphilis. Sigmoidoscopy revealed a 2 × 2-cm indurated rectal mass 5 cm above the anal verge. Darkfield examination of rectal exudate revealed motile treponemes and rectal biopsy of the mass showed diffuse infiltration of plasma cells and lymphocytes. Large numbers of spirochetes were present on silver stain of the rectal biopsy specimen and these were shown to be Treponema pallidum by indirect immunofluorescence. The rectal mass and symptoms resolved following penicillin therapy. This case and a review of previously reported cases of anorectal syphilis emphasize the significance of these often neglected and misdiagnosed lesions of syphilis.

III. Non-epithelial Large Intestine

Non-epithelial tumors of the gastrointestinal tracts are very rare. Its incidence is about 1-5% of the all neoplasmas of the gastrointestinal tract. Benign non-epithelial tumors in the small intestine are occupied about 60% of all benign tumors. But there is very low frequency in the stomach, colon and rectum. The incidence of the malignant non-epithelial tumors (sarcoma) is very rare, 1-2% of all malignant tumors in stomach and large intestine. However, in the small intestine, it is showed to be over 40% in sarcoma. Of all benign non-epithelial tumors, histologically leiomyoma and benign lipoma are very common. Most of sarcoma are malignant lymphoma and leiomyosarcoma, and other tumors are very rare.It is very important to differentiate leiomyosarcoma from neurogenic sarcoma. Almost cases which were previously reported as neurogenic tumor, especially neurinoma or neurogenic sarcoma of the gastrointestinal tract, are probably leiomyosarcoma and leiomyoma. In this paper we emphasized the importance of histological differential diagnosis between leiomyosa-rcoma and neurogenic tumors in the gastrointestinal tract. And we reported a case of solitary neurogenic sarcoma of the small intestine.Recently, lymphoid-plasmacytic disorders associated with appearance of a unique serum and urinary protein, which is Fc-fragment of the counterpart of the heavy chain of Ig-G, are known as heavy chain disease. We have experienced a case of heavy chain disease, which was involved the gastrointestinal tract. We cannot find any reports of heavy chain disease involving the gastrointestinal tract. Histologically heavy chain disease features (reticulum cell sarcoma like and Hodgkin desease like) but malignant lymphoma, and remarkable plasma cell infiltration was noted. This feature is very characteristic of this disease. Ig-A heavy chain disease (α-chain disease) arises from small intestine. The characteristical histoligical findings is diffuse plasma cell infiltration and clinically associated with malabsorption.

Intra-articular injection of high-molecular hyaluronic acid. An experimental study on normal adult rabbit knee joints.

High-molecular hyaluronic acid was injected repeatedly into normal knee joints of adult rabbits. Histologically the articular cartilage was not affected by this treatment. The content of chondroitin sulphate, assessed by a histochemical method, was not altered and neither was the water content of the hyaline articular cartilage. On the other hand, in the synovial membrane of joints treated with hyaluronic acid a diffuse infiltration of plasma cells and lymphocytes was observed, indicating that the hyaluronic acid administered exerts its action via the synovial membrane.

The pathology of so-called Mediterranean abdominal lymphoma with malabsorption.

Surgical specimens, postmortem material, or both from 22 patients with the syndrome designated as “Mediterranean abdominal lymphoma with malabsorption” were studied in detail. All patients exhibited a malabsorption syndrome. In most of those carefully followed from the onset of the disease, the syndrome seemed to have preceded the development of palpable abdominal masses. In 20 of the 22 patients, intestinal tissues were available for histologic study. In all specimens, diffuse severe plasma cell infiltrations were evident in the intestinal mucosa and submucosa. Malignant lymphomas in the form of single or multiple circumscribed intestinal tumors occurred in 14 of these 20 patients and malignant lymphomas of the mesenteric lymph nodes in two. In four patients, no malignant lymphomas were evident. These observations suggest that the diffuse plasma cell infiltrations, rather than the malignant lymphomas, were responsible for the malabsorption syndrome. There was no morphological evidence that the malignant lymphomas observed in 75% (16 of 20) of the patients were histogenetically related to the diffuse plasma cell infiltration. The possibility is suggested that this abnormal, though not provably neoplastic, proliferation of plasma cells is a morphological manifestation of an immune deficiency state which predisposes the patients to the development of malignant lymphoreticular neoplasms.

A Case of Myelomatosis with Diffuse Plasma Cell Infiltration of Lymph Nodes, Liver, Spleen, Kidneys, and Lungs

Acta Medica ScandinavicaVolume 115, Issue 5 p. 514-523 A Case of Myelomatosis with Diffuse Plasma Cell Infiltration of Lymph Nodes, Liver, Spleen, Kidneys, and Lungs A. TYBJæRG HANSEN, A. TYBJæRG HANSEN Medical Department, Præstø District Hospital, Næstved. (Denmark) Chief Physician: S. A. Holbøll M. D.Search for more papers by this author A. TYBJæRG HANSEN, A. TYBJæRG HANSEN Medical Department, Præstø District Hospital, Næstved. (Denmark) Chief Physician: S. A. Holbøll M. D.Search for more papers by this author First published: January/December 1943 https://doi.org/10.1111/j.0954-6820.1943.tb15866.xCitations: 3AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume115, Issue5January/December 1943Pages 514-523 RelatedInformation