An observer-based control method with parallel Q-filter is proposed to reject unknown multiple narrow-band disturbances for line of sight stabilization in telescope systems. In general, wide-band or multiple narrow-band disturbances rejection of observer-based control can be transformed into designing Q-filter, which could be too high-order to achieve fully-accuracy digital implementation, resulting in degrading the closed-loop performance or even causing instability. Therefore, a new parallel type of Q-filters is proposed to flexibly adjust the number of Q-filter in the sensitivity function and effectively reduce the computational complexity. A sufficient condition of the effectiveness for the parallel Q-filter and the closed-loop stability is derived and verified through simulations. Furthermore, disturbance frequencies can be on-line identified to adaptively optimize the Q-filter parameters. The effectiveness of the proposed method is validated on the image-based stabilization subsystem of a segmented lightweight large-scaled diffractive telescope.